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Ozempic shows anti-aging effects in trial
- p1dda 1y agoPlease stop with these obvious pharma ads, nobody needs to take Ozempic! Change your lifestyle and most importantly: STOP EATING JUNK FOOD
- drcode 1y agoBut junk food is fun: Maybe we can eat junk food, have fun in life, and still be reasonably healthy, with the help of science (and if glps don't work well enough to allow this, then maybe the next medicine in the pipeline)
- recursive 1y agoThe drug just makes you eat less.
- chilldsgn 1y agoIt really puzzles me how people would just pop a pill instead of make some lifestyle changes. Maybe it's just my personality type, but it disturbs me how most people just want something quick and easy instead of doing the actual work and becoming overall better via a real learning journey by struggling through changing bad habits. But whatever, they do whatever works for them! I don't like pharma.
- BirAdam 1y agoAddiction is quite real, and food companies turned it into an art. For some people, quitting an addiction is easy. For others, it’s super hard. It’s easy to say “make better habits,” but at this point, Ozempic has likely saved more lives than AA.
- aaronbaugher 1y agoBecause when people say "just make some lifestyle changes," "just" is doing a lot of heavy lifting there. Being fat really, really sucks, so most fat people have tried to make lifestyle changes, but they've gotten a lot of bad advice over the past half-century. They've cut back on fat, especially healthy animal fats, because that's what the government/medical/nutritional complex said to do, replacing them with "healthy grains," and only gotten fatter. They've tried to trim calories or portion sizes, which is difficult and ineffective for a lot of reasons. They've tried so-called weight-loss products promoted by corporations with millions to spend pushing them. They've thrown themselves into exercise plans, and while exercise is great for a lot of reasons, it doesn't have much effect on weight loss. Even when they go outside the mainstream and try something that can actually work, like cutting carbs or fasting, it's difficult because losing weight isn't just the reverse of gaining weight. Fat cells aren't just buckets that fat falls into and can fall out of. Once energy is stored in the form of fat, it has to be burned to be removed, which requires a different set of hormones and enzymes than storing it did. Maintaining that metabolic mix generally requires an enormous amount of willpower, not just some lifestyle tweaks. People who have plenty of willpower to succeed in other areas of life like career or relationships can be defeated by it. I don't like big pharma either, and I'm losing weight (slowly) with fasting rather than trying these drugs. But it's hard to blame people for using them, if it's a temporary fix and they're going to maintain their new weight through diet. I'm skeptical that it'll go that way for many, but I suppose there's hope.
- chilldsgn 1y agoI think I was a bit vague and blunt with my comment, and I agree with what you say here 100% For me lifestyle changes weren't easy and as simple as "lifestyle changes". Lifestyle changes involved huge amounts of willpower, and still do to some extent. Nothing that's really valuable is possible with an easy way out. From personal experience, consistently doing something hard and building that habit is so much more sustainable long term than temporarily popping a pill and expecting the problem to stay away when they stop. I've known people who used Ozempic for some time, then stopped when they reached their goal weight, then just end up putting on that weight again. I don't blame Ozempic for it, it did its job well. I was overweight, unhealthy and no amount of exercise and eating so-called "healthy low fat" dietician-recommended foods helped me get healthier and leaner. I had to let go of the beliefs I held about how nutrition should be. I don't blame anyone, I just find it personally puzzling that people don't seem to want to challenge the status quo because the status quo isn't working. Fasting, low carbs and cutting out sugar completely has done so much good for me, not just on a weight loss level. It took years of self-education, figuring out what works for me and my body to get where I am now. Physical health probably isn't one of their top personal values. This goes deeper than just a simple "lifestyle change". So yes, if this works for some people and helps them live better, good for them, and I really hope they thrive on this.
- wpm 1y agoOh fuck why didn’t we think of that!? You’re so smart!
- shlant 1y agoit's good we have so many geniuses in these comments solving the obesity epidemic! if only they spoke up sooner :(
- xeromal 1y agoI can't open this link but I wonder if the weight loss or the medicine itself is performing the anti-aging
- declan_roberts 1y agoI was just researching this myself before investing in LLY. For cardiovascular health, they see benefits even with people who are at a healthy BMI, which suggests therapeutic effects beyond just losing weight.
- xeromal 1y agoVery interesting! Thanks for chiming in.
- jjtheblunt 1y agoit could also suggest that BMI isn't a great metric, though, as has been in the news often lately. regardless, thanks too.
- Tade0 1y agoIt isn't. Waist-to-height ratio is a much better predictor of cardiovascular issues - you want to stay below 0.5. I never went above 25 BMI but I wouldn't call myself a healthy person as it's obviously like that only due to low muscle mass.
- riku_iki 1y agowhat would be reversing biological age from regular running and eating chicken breast + veggies with olive oil.
- HarHarVeryFunny 1y agoYou can tell if that regime reverses aging when you instead start wanting to eat chicken nuggets and mac & cheese.
- hackeraccount 1y agoNice.
- amanaplanacanal 1y agoWish I could run. Knee says no.
- avoutos 1y agoDo you have an injury? Knees over toes exercises can do wonders for rehab. From a form perspective, it also helps to avoid heel-striking.
- amanaplanacanal 1y agoNo injury I'm aware of. I've never been a runner, trying to start in my 60's. Starting with c25k plan, so it's mostly walking with short bursts of very slow running. No pain during run, but for a week afterward get pain in left kneecap whenever I go up stairs. Everything I've read about kneecap pain is not good. Not heel striking. I wear thin shoes with no padding (barefoot style) so I couldn't even if I wanted to. It could be some kind of form issue, I guess. It's a mystery.
- riku_iki 1y ago> I wear thin shoes with no padding (barefoot style) so I couldn't even if I wanted to. if your form is wrong, it totally could result of extra impact on knee. Its better to run with padding than do not run at all. > It could be some kind of form issue, I guess. few points to check: * make sure you strike under your center of gravity and not in front of it * even you don't do heel striking, make sure your feet is almost flat, this will engage bunch of muscles for impact ammortization. * make sure you don't jump up and down, but more like your hips are floating forward in straight line
- lurking_swe 1y agoThis isn’t really surprising at all IMO, but it’s nice that it’s been confirmed. > “The researchers believe semaglutide’s anti-aging properties stem from its effects on fat distribution and metabolic health. Excess fat around organs triggers the release of pro-aging molecules that alter DNA methylation in key aging-related genes. By reducing this harmful fat accumulation and preventing low-grade inflammation - both major drivers of epigenetic aging - semaglutide appears to create a more youthful biological environment.“ In other words, being medically obese ages your body quite a bit, its stresses out your body with inflammation, etc. Taking Ozempic helps people lose weight, which also reduces inflammation. This is sort of like saying we proved rain (usually) increases humidity lol. A very obvious finding. The article even says “ Randy Seeley from the University of Michigan Medical SchoolView company profile expressed little surprise at the findings” :)
- torginus 1y agoYeah this is pretty much a nothingburger. I guess being fat causes biological damage similar to aging, and losing weight (which Ozempic helps with) reverses the process.
- ifwinterco 1y agoYeah, it looks like it's basically just saying: 1) Being fat is really bad for you 2) Moderate calorie restriction may have some health benefits Both of which we already knew, the second one being a bit more controversial but a hypothesis that has been around for decades
- ehnto 1y agoI think it's controversial mostly because it is mixed in with morality, self-image, personal freedom etc. I think everyone has the right to be fat, if they have chosen to prioritise other aspects of life, but I think people should be informed and consider the "being fat can be healthy" movement to be quite disingenuous. Do what you want, but be realistic about it, and tricking people into ignoring the negative effects is not fair to them either.
- morninglight 1y agoThere is another study that comes to mind. https://www.pnas.org/doi/abs/10.1073/pnas.2420092122 https://www.pnas.org/doi/abs/10.1073/pnas.2420092122
- readthenotes1 1y agoI have no idea why you're down voted. The replication crisis is real, and it is well known that fraud is a part of it
- pie_flavor 1y agoBecause it's a content-free dismissal. No attempt is made to link it to this study in particular.
- readthenotes1 1y agoIf the poster had said "given the replication crisis and outright fraud endemic in scientific publications these days, I have little faith that this research will bear fruit for the general population" Would that have been specific enough?
- aswegs8 1y agoMaybe because that is a whole different topic that is only tangentially related to this thread?
- V__ 1y agoAny study which uses epigenetic clocks can be discarded. There is to my knowledge no test which produces reliably measurements which don't have big error bars. The only conclusion this study can really make is: Ozempic changes the 'thing' which the epigenetic clock test also measured.
- metalman 1y agoit does seem that there is no reliable connection with "epigenetic clocks" where people are shown to be dying at the same bio age, regardless of calender age......all of the mortality estimating calculations rely on many "factors", so the "ozempic" effects will be just part of a puzzle, where I will bet anything that attitude, demenour, , basic personal conduct will weigh in as the hinge pins that everything else pivots around..........stress, and how that is delt with, and anyone who thinks that one compound is going to reset the whole clock on a complex organism is kidding themselves, which if done right, works ;) so....it's all for the good
- taeric 1y agoIt remains eye opening to see how much losing weight does to people.
- pitpatagain 1y agoThis is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
- kjkjadksj 1y agoPeople on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.
- radiofreeeuropa 1y agoAny means of attaining weight loss at a similar rate will tend to do the same thing. Especially if you’re starting from quite-heavy, not just dropping 20lb or something.
- YokoZar 1y agoIt varies. People are often thinner in their twenties than their thirties and forties. If you browse some before and after pictures the ones who have had their skin tighten tend to look younger for that reason alone.
- kjkjadksj 1y agoEven naturally thin people have buccal fat and healthy looking cheek and jawlines.
- pitpatagain 1y agoOr that's who you notice. My husband takes ozempic for type 2 diabetes and it completely fixed his blood sugar while causing very moderate weight loss. What the people in this study have causes abnormal visceral fat accumulation in the belly and back and itself causes disturbing changes in body shape and appearance, does not respond or normal weight loss, and hasn't had real treatment options. That ozempic has beneficial effects for it in an RCT is actually awesome, it's the framing given by the headline that is bad.
- cultofmetatron 1y ago[flagged]
- breakingrules3 1y ago[dead]
- some_random 1y agoI find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.
- jbentley1 1y agoNaturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.
- kmeisthax 1y agoAs a talented engineer, I hate AI coding because it doesn't do what it says on the tin. If GLPs made people hallucinate weight loss that wasn't actually happening, I'd be angry about them too.
- thaumasiotes 1y agoEver seen "Shallow Hal"?
- amelius 1y agoIt is not fun when your superpower becomes a commodity.
- stronglikedan 1y agoI'd wager that you can only call an engineer talented if they know enough to hate AI coding.
- zer00eyz 1y ago> I know many talented engineers who hate AI coding. People whos primary skill is coding, hate AI coding. No talented engineer hates AI coding. The distinction is this: a coder knows how to use their tools, an engineer knows how to work with people, understands product, process, users, and knows how to use their tools. Talented engineers hate the HYPE around AI. And those of us old enough to remember sigh and think "This is just dreamweaver all over again". It is ESB's with "drag and drop" workflow tools. AI is just another useful tool that a good engineer can pick up and put down where appropriate.
- wolfi1 1y agoIs the term "biological age" even well defined?
- sharkjacobs 1y agoPresumably it is in the narrow context of the study, since they need something they can consistently measure and compare > The researchers used epigenetic clocks to assess biological aging - sophisticated tools that identify patterns of DNA methylation, chemical tags that affect gene activity and shift predictably with age
- sharkjacobs 1y agoI think you're very correct to identify the gulf between what the average MedPath headline reader understands "biological age" to mean, and the very specific chemical tags being measured and reported
- lysecret 1y agoIt’s so fascinating that we just keep on finding more positive effects.
- glp1guide 1y agoWe also like to keep track of all the bad ones too[0] (tl;dr they're actually pretty reasonable). It's amazing what lowering inflation, reducing body weight can do to the body. It's almost becoming irrelevant that GLP1 Receptor Agonists were originally for type 2 diabetes (i.e. reducing HbA1c) -- the effects are profound. Kidney health, heart health, overall health, longer lives -- all for the low low cost of gastrointestinal problems (which can be serious, especially if dehydrated). [0]: https://glp1.guide/content/are-glp1-side-effects-all-the-same/ https://glp1.guide/content/are-glp1-side-effects-all-the-sam...
- mensetmanusman 1y agoThey are all downstream from obesity; so it’s obvious from that standpoint since obesity is so dangerous.
- sjw987 1y agoIt's fascinating that many of the benefits are the same benefits as just losing weight in general.
- JumpCrisscross 1y ago> many of the benefits are the same benefits as just losing weight in general Many, but not all. Losing weight through diet and exercise has no effect on alcoholism, for example.
- thurn 1y agoAre we close to having generic semaglutides e.g. available in India? Or locked into high prices for the foreseeable future?
- Someone1234 1y agoGeneric Semaglutide is already produced on a massive scale throughout the world. However, it is unlawful to import and sell and will remain so until 2032 in the USA. In other markets, where it is under patent, it is significantly cheaper than the $500/month or more in the US currently. For example in the UK it is roughly $150/month USD privately (i.e. not through the NHS). In China it will be out of patent within two years.
- readthenotes1 1y agoIirc, that pricing will change in the US as Trump will require that the price of drugs to Medicaid patients must match or be less than that of any other developed nation. Since about 1/4 of the people in the US are on medicaid, close to 90 million, that means the drug manufacturers will probably raise the price for everyone else in the US because they got to get their profits somehow... https://www.whitehouse.gov/fact-sheets/2025/07/fact-sheet-president-donald-j-trump-announces-actions-to-get-americans-the-best-prices-in-the-world-for-prescription-drugs/#:~:text=On%20May%2012%2C%202025%2C%20President,those%20paid%20by%20similar%20nations. https://www.whitehouse.gov/fact-sheets/2025/07/fact-sheet-pr...
- Someone1234 1y agoUnfortunately, per the link, it sounds like a voluntary arrangement. Essentially they're asking drug companies nicely to stop ripping off Americans. If they're serious about this, they would introduce legislation rather than send strongly worded letters to pharma companies.
- readthenotes1 1y agoThat would be pretty , unusual - Congress has shown an exceptionally strong bias to support medical industry profits over health Care through the decades. I wonder if the bribery (campaign donations) has anything to do with it?
- neves 1y agoBe very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term systemic effects of these drugs are still largely unknown.
- jorts 1y agoHaven’t these types of drugs been in use for ~15 years?
- throw-qqqqq 1y ago> Haven’t these types of drugs been in use for ~15 years? The predecessor of semaglutide, liraglutide has been sold since 1998. GLP-1 has been studied since the 70s. The first human was injected with GLP-1 agonists in 1993 IIRC.
- mapontosevenths 1y agoFurther, Ozempic itself is nearly 10 now and some people have been on Exenatide for 20+ years continuously now. These drugs are not novel, or new and we absolutely know the long term health impact.
- neves 1y ago20 years isn't a lot of time
- mapontosevenths 1y agoIf the side effects are mild enough I don't notice for 20+ years, that's fine by me. I'll take it. Obesity had side effects that were killing me.
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- fuckyah 1y ago[dead]
- jsbg 1y agoDoesn't biological age normally go down with weight loss? Is it just a corollary of the off-label effects of the drug?
- anitil 1y agoI was wondering a similar thing - even as simple as wear-and-tear on your joints, hips and back is less as a smaller bodyweight. I notice I even look younger at a lower bodyweight (up to a point)
- radicalriddler 1y agoIt's not that it's going down, the article suggests that it slows. If I lose 20 kilo's, my "biological age" might go down 2 years, but that doesn't mean it's "slowed"
- GenBiot 1y agoSlowing in this context means going down. Basically they look at 'age acceleration', I.e. how old are you epigentically compared to chronologically. They saw a reduction of several years in this measure over a much shorter period, basically meaning their epigenetic ages went down. Although one of the clocks they used, DunedinPACE, only looks at pace of ageing, so in that case you can only infer that it slowed (as you do not get an 'epigenetic age' figure from DunedinPACE).
- HocusLocus 1y agoI guess maybe I'm one of the few who consider "reversing 3.1 biological years" to be a personal insult. Something that polled well in a group of pre-kindergarteners. What happened, some statistical bloodwork metric was tortured to produce such a claim? A mouse population survived the lab a little longer?
- tzs 1y agoHere's an article that answers your question [1]. It in the second bullet point near the top. [1] https://trial.medpath.com/news/5c43f09ebb6d0f8e/ozempic-shows-anti-aging-effects-in-first-clinical-trial-reversing-biological-age-by-3-1-years https://trial.medpath.com/news/5c43f09ebb6d0f8e/ozempic-show...
- HocusLocus 1y agoYes, epigenetic clocks discovered in 2010 and even the researcher who discovered them might feel insulted by the phrase of a prescription drug declaring "reverse biological aging 3.1 years"
- aswegs8 1y agoIf you're really interested in that and not just trolling, these are the measures used by the study: After adjustment for sex, BMI, hsCRP, and sCD163, semaglutide significantly decreased epigenetic aging: PCGrimAge (-3.1 years, P = 0.007), GrimAge V1 (-1.4 years, P = 0.02), GrimAge V2 (-2.3 years, P = 0.009), PhenoAge (-4.9 years, P = 0.004), and DunedinPACE (-0.09 units, ≈9 % slower pace, P = 0.01). Semaglutide also lowered the multi-omic OMICmAge clock (-2.2 years, P = 0.009) and the transposable element-focused RetroAge clock (-2.2 years, P = 0.030).
- charlie0 1y agoIt it ozempic specifically or just the side effect of eating less (which also has tons of evidence for extending life)?
- getpost 1y agoIn a recent podcast[0], Ben Bikman explained some of background and pitfalls of GLP-1 drugs. When the drugs were first prescribed, dosages were much smaller than the dosages now prescribed for weight loss. Microdosing might be a better and safer strategy. The podcast is only 3 hours long! The GLP-1 discussion starts at 2:09:53. [0] https://www.foundmyfitness.com/episodes/ben-bikman https://www.foundmyfitness.com/episodes/ben-bikman EDIT: ycopilotFYT version https://www.cofyt.app/search/dr-ben-bikman-how-to-reverse-insulin-resistance-th-sOT_FWQgpET38BIXxNe4gJ https://www.cofyt.app/search/dr-ben-bikman-how-to-reverse-in...
- Dah00n 1y agoOnly 3 hours!
- scrozart 1y agoLots of anecdotes and opinions in the thread. Read the post and the science.
- heraldgeezer 1y agoFasting is good. I do it without medicines and crap. 24h-48h fast. Skip meals. BMI back to 19 and it feels GOOOOD BABYYY.
- burnt-resistor 1y agoIt's not GLP-1's in particular, it's protective effects of manifold evolutionary adaptations to semi-regular caloric deficits. Cancer and CHD go way, way up with Westernized diets.
- glp1guide 1y agoNote that these results probably apply to Mounjaro/Zepbound as well, because they are the most effective GLP1s on the market right now: https://glp1.guide/content/semaglutide-vs-tirzepatide-clinical-trial/ https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic... My bet is on the reduction in inflammation -- it's a notoriously beneficial positive side effect of GLP1 Receptor Agonists, along with the obvious reduction in weight or HbA1c.
- glp1guide 1y agoIf you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground gray market peptide enthusiasts (you can find them on reddit and elsewhere), but the results are quite intense. [EDIT] Just to be clear, gray market Retatrutide is illegal, I'm not encouraging you to buy it or do even take GLP1s in general. The point is that we have a preview of anecdata from people (with obviously high risk tolerance) taking this drug.
- toomuchtodo 1y agoWhat's the difficulty level of obtaining Retatrutide through non traditional channels?
- deleted 1y ago[deleted]
- glp1guide 1y agoIt's completely illegal -- the drug is not for sale, obviously is not FDA approved, and is not manufactured anywhere, the only safe/legal way to get it is a via an ongoing trial: https://trials.lilly.com/en-US/trial/580035 https://trials.lilly.com/en-US/trial/580035 As one might imagine though, capitalism found a way. A LOT of compounding pharmacies are now very good at manufacturing GLP1s (not necessarily the case that the knowledge transfers, but I imagine networks/knowledge sharing groups do), so gray market has sprung up to supply adventurous people with Retatrutide.
- globular-toast 1y agoWhy is it illegal? Are drugs illegal by default or has it been specifically controlled/scheduled? I looked up which drugs are scheduled in the UK and found the list is about 100x longer than I thought it was and in fact the government don't even publish a definitive and exhaustive list of all substances.
- stephenhandley 1y agoI guess Ozempic face is what "anti-aging" looks like? Nothing to see there lol. The backlash on GLP-1s is gonna make thalidomide look like penicillin.
- anovikov 1y agoI know why people hate Ozempic. It is because it devaluates struggle and voids moral superiority of those who did keep themselves from becoming obese by self-restriction before: now these people feel like fools because all of a sudden, everyone is becoming slim, and the advantage of being slim disappears. They naturally question how is it fair. Well, life's not fair.
- IncreasePosts 1y agoI hate ozempic because I have no reason to be prescribed it and if it has these anti aging effects or improves self control with other vices, I'm missing out and the ex-fatties will all live longer than me
- anovikov 1y agoSadly it seems to have very little effect in these domains on non-overweight people. In studies, on large groups, Ozempic helps people quit drinking a lot better than it helps quitting smoking - because alcoholics tend to be overweight but smokers tend to be skinny. The higher was someone's BMI, the more pronounced are ALL of the semaglutide effects, even those not apparently associated with weight at all.
- alistairSH 1y agoAs noted in the article, and in some other posts here, the effects are seen in patients who are overweight or have diabetes (and thus generally qualify for Ozempic). None of the studies I've skimmed indicate Ozempic is directly slowing aging or whatever else - it's all a knock-on effect from weight loss and calorie restriction. IE, if you can self-restrict, you get the same benefits. You just have to deal with that little voice in your head that keeps yelling "feed me a pizza!!!" (at least that's what mine usually says). But, yeah, I hear ya, I wouldn't mind doing a few months at a low dose to get my body fat % back down near 10%, but I'm nowhere near "needing" the drug and the only way I'm getting a prescription is probably through a shady online doctor.
- woile 1y agoThat's if people think obesity is just the individual's fault. In nutrition there's a distinction between psychology factors, the environment (called the obesogenic environment), genetics, social factors, etc. If you live in the US it must be really hard to avoid being overloaded by food, so I think the real angry group of people will be companies, not being able to force people to eat more, I welcome that!
- chickenzzzzu 1y agoI just started taking zepbound and I went from binge eating 2-3 times a day to eating half a meal overnight. I've already lost 12 pounds (6% of my bodyweight) in a week, which is definitely too much, but I was full of salt. I basically pickled myself. The side effects are quite stark. My stomach feels paralyzed. I became anorexic (again) overnight
- RataNova 1y agoWorth noting: the anti-aging effects may be a byproduct of improved metabolic and inflammatory profiles, not magic cellular rejuvenation
- qiine 1y agothe only thing I want to know actually
- ap99 1y agoThis, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (because it only gets worse with age). And that means a lifelong ozempic customer.
- dan-robertson 1y agoIs it possible to avoid having the same discussion every time anything related to Ozempic comes up?
- sjw987 1y agoIt's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of nutrition and fitness are important life skills. At some point everybody should be developing them. If people can't be arsed doing that and we give easy shortcuts for everything in life, what's the point in being alive? This argument comes up time and time again because it's common sense, yet people always seem to want to ignore it because deep down they are being lazy and undisciplined.
- guerrilla 1y agoNah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc.
- deleted 1y ago[deleted]
- beeforpork 1y agoJust a quick check list for better understanding of the placement of the study: Is this the first study of its kind? The only one? Is it medically and scientifically sound and well-documented? Does it apply to people without (HIV-associated) lipohypertrophy? Is the effect temporary, i.e., what happens when drug use is terminated? Does it cure the lipohypertrophy or is this a life-long disease that needs medication? How are TruDiagnostic and Novo Nordisk related to each other either generally or concerning this study?
- a5c11 1y agoBasically everything that can be improved by exercising and maintaining a healthy diet.
- gcanyon 1y agoThe article says nothing about whether they controlled for the associated weight loss. That would still be interesting, but less surprising.
- Roark66 1y agoThis is all nice and all, but how can they tell these benefits are from ozempic or actual calorie restriction? Were talking about people that suffer from hiv induced bad fat distribution. I assume this means they have conditions such as fatty liver etc. Simple calorie restriction will improve their life. The study would have to do the exact same calorie restriction for both groups. One on ozempic, one without. Then if one group showed benefits that would he clear. Even if the mechanism was something like they were stressed less by hunger. Ozempic/semaglutide is great stuff, but it has same dangers as calorie restriction. If you don't watch carefully what you eat (increase protein, supplement with micronutrients) you can become deffiecient and end up in a very unhealthy place.
- Damogran6 1y agoGLP-1, amongst other things, _enables_ the calorie restriction. It takes away the noise and tendency to overeat.
- wosined 1y agoWhere is the link to the study.
- BobbyTables2 1y agoJust wish there weren’t so many false “studies” promoting benefits of medications that have none. Only slightly better than 1800s snake oil… Would be darkly hilarious if the financial cost of semaglutides is what actually contributes to the weight loss. Ozempic is currently the NVIDIA of the pharmaceutical industry.
- JumpCrisscross 1y ago> Only slightly better than 1800s snake oil In the same vein folks were disputing the validity of vitamin C until WWII [1]. There is no shortcut to science. You have to weigh the evidence. Currently, the evidence in favour of GLP-1 agonists is overwhelmingly positive. [1] https://pubmed.ncbi.nlm.nih.gov/23183299/ https://pubmed.ncbi.nlm.nih.gov/23183299/
- paulcole 1y ago> Just wish there weren’t so many false “studies” promoting benefits of medications that have none What’s an example of such a study?
- BobbyTables2 1y agoHow about “Phenylephrine”? It’s nearly 100 years old and widely used after Pseudoephedrine was more restricted so people couldn’t make meth as easily. Yet, studies not conducted by pharmaceutical manufacturers find it mostly ineffective. Of course, the drug companies publish studies showing it to be effective… Have you ever taken each (not together)? I’ve never heard someone say Phenylephrine did anything for them. Anecdotally, it’s utterly useless for me… I suspect drug companies didn’t want restriction of Pseudoephedrine to decrease sales, so they pushed crap forward to maintain revenue. (Yes, it still isn’t all that hard to get Pseudoephedrine, but one can’t just pick it off the shelf — a significant mental barrier)
- PeterStuer 1y agoIt works because people feel 'full' sooner. They do still try to overeat, but feel they can't (and yes, there is habituation as they try day in day out). I'm pretty sure the food industry has been working on a neutralizing agent to add to their preparations since day 1, so the 'victory' wont last. As for longer term consequences? Who knows?
- sameesh 1y agoIt sounds like the researchers failed to compare their semaglutide group to a calorie-controlled placebo group. The beneficial changes noted in the semaglutide group could very well be due to reduced calorie diet, rather than a specific effect of the drug itself. This is why people end up skeptical of academic types and science publications.
- eirikbakke 1y agoThis is a weird (possibly AI-generated?) summary of an article pre-print that is not even cited on the page. I think it's this one: https://www.medrxiv.org/content/10.1101/2025.07.09.25331038v1 https://www.medrxiv.org/content/10.1101/2025.07.09.25331038v... Best to wait for the final, peer reviewed version of the article.
- ACV001 1y agobullshit to increase sales
- koliber 1y agoI'm curious how they measured the biological age. My trainer has a scale that measures biological age and it seems very correlated with weight. When I weight less I am biologically younger, and vice versa. Ozempic does a good job at aiding weight loss, so I am wondering if this is a large contributor to the effect they saw.
- roody15 1y agoReduced calories also associated with anti aging effects ? https://pmc.ncbi.nlm.nih.gov/articles/PMC9042193/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9042193/ Maybe related with Ozempic?
- Oceoss 1y agoBe careful when you read 'anti-aging' it's very often just clickbait
- tracker1 1y agoIn my experience it also showed gastroparesis and fecal vomiting over the course of a couple years. Coming off meant the feeling of starvation 24/7 for about 11 months before starting to get better, and 1.5 years off the medication now, I'm still having digestive issues. Went back to keto (mostly carnivore) in May and a few pounds away from 50# down from my max weight, managed to cut way back on insulin (some days not needing any). Overall, I wish I'd never heard of Trulicity or Ozempic. I didn't lose weight on them, and the seriously messed me up. The negative effects of coming off are pretty bad on their own on top.
- declan_roberts 1y agoYou have fecal vomiting and stayed on the drug for years?
- tracker1 1y agoIt's not like it started a day after I first took the drug, my gastro issues got worse over the course of the time I was on it. I didn't know it was being caused by it. I was literally seeing 3 doctors over the gastro issues... wasn't until the lawsuit against Trulicity that I put it together and stopped taking it. But sure, it's MY fault I didn't figure out what several doctors didn't over the course of that second-third year or so.
- smeeger 1y agoliterally every time i turn around there is another convincing case study indicating that everyone should be taking ozempic. when they work the bugs out of ozempic it will truly be awesome