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Semaglutide linked to lower predicted dementia risk
- randycupertino 2mo agoThis is interesting. Diabetes is a well-known risk factor for dementia.
- toomuchtodo 2mo agoWestern disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-cancer-cells-and-help-them-spread https://www.sciencealert.com/common-sugar-appears-to-loosen-...
- Alien1Being 2mo ago[flagged]
- toomuchtodo 2mo agoJust pattern matching as an autistic human. Similar results were seen on a ketogenic diet (and to some extent, intermittent fasting). What do they have in common? Sugar intake reduction. Is it surprising sugar potentially fuels cancer, contributes to dementia, etc? It shouldn’t be. It’s indirect and a casual connection. There is no health benefit to a high sugar or Western diet, only downside. I think calling it poison is hyperbole, but it’s definitely not healthy, based on all available evidence. I expect to see longitudinal scale results over the next decade as everyone starts taking GLP-1s. (I take a glp-1, they’re an amazing drug class, it changes how your brain operates, charlie day waving arms in front of a whiteboard meme here)
- BenzeneDream 2mo agoThats due to caloric restriction. A high fat diet isn't going to helpful as well. To think that people cut sugar but continue to eat far too much meat and fat... yikes.
- picofarad 2mo agoLol there's only three macros. If you cut out carbs you necessarily increase protein and fat, for the same calories. Unless you are merely saying people should eat less; but that should go without saying.
- tptacek 2mo agoI don't see anything RFK-like in that comment.
- diath 2mo ago> Western disease and sugar heavy diets broadly speaking No, just being sedentary. There's no such thing as acquired diabetes in physically active people.
- victorbjorklund 2mo agoDoubt you can eat just pure fructose for 30 years and ”move” and avoid diabetes.
- zemvpferreira 2mo agoAt the risk of being argumentative I had a horrible diet for the past ~10 years and carried 50 extra pounds. However I also exercised a lot as a hobby and to my shock my glucose and other bloods always came out in the normal range. This year I started Mounjaro and dropped the 50 pounds. Curious to see what my next checkup shows.
- AlexErrant 2mo agoPeople kick around the idea of the "personal fat threshold". E.g. caucasians seem to be better at carrying fat than, say, Southeast Asians. White people seem to be able to better store fat without metabolic side effects; SEA seems to get T2D at a much lower bodyfat percentage.
- zemvpferreira 2mo agoPossibly maybe, but plenty of caucasian friends at my old bodyweight/fat percentage had/have horrible markers. I lean more towards the protective effect of exercise.
- AlexErrant 2mo agoAgree 100%. To quote myself: --- Which do you think is worse: smoking, or not exercising? https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2707428 https://jamanetwork.com/journals/jamanetworkopen/fullarticle... Look at Figure 2C in particular. The hazard ratio of smoking is 1.41. The hazard ratio between "Low" (<25th percentile) and "Below Average" (25th-49th percentile) cardiovascular health is 1.95. In other words, it is better to be a smoker than in the lower 25% of non-exercisers. By far. It's not even close. https://news.ycombinator.com/item?id=40080849 https://news.ycombinator.com/item?id=40080849 Let me emphasize: that exercise hazard ratio is between LOW and BELOW-AVERAGE.
- adjejmxbdjdn 2mo agoFirst of all it’s a nice study. The dosages they always give are way too high and mice are rarely a reliable model. But you’re also ignoring the fact that the same study shows that glucose inhibits the behavior. So your claim that the study indicates its sugar is incorrect. The study indicates a possible impact from fructose which is countered by glucose, so the real issue is the fructose to glucose ratio. Table sugar providing equal fructose and glucose molecules is acquitted by this study.
- toomuchtodo 2mo agoAdditional citation: Babies born under sugar rationing grew into adults with lower cancer risk - https://news.ycombinator.com/item?id=49345843 https://news.ycombinator.com/item?id=49345843 - August 2026
- gloryjulio 2mo agoSugar heavy diets is everywhere IF people can afford to have them if you look at the data. There is no such thing as Western vs Eastern in this sense. Note I am not Western
- roryirvine 2mo agoAs is being sedentary - there are probably lots of interconnected factors in play, and GLP-1 receptor agonists seem to help with more than one (perhaps even many) of them. Unpicking the exact chains of causation is likely going to be extremely complex, but the general picture continues to look good.
- hobonation 2mo ago[dead]
- hinkley 2mo agoWe should probably be studying people who wear smart watches and collecting the activity levels to control for that. But if GLP-1 makes you more active, who am I to complain. There's the reason they approve stomach stapling surgeries on morbidly obese people. They are so compromised that anything that gives them a chance to be more active offsets some of the risks of surgery, and the risks of inaction.
- AFF87 2mo agoWe are very early in the semaglutide world, exciting times ahead!
- ndr 2mo agoFor sure we still need to find out many related outcomes. Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss. https://www.ema.europa.eu/en/news/prac-concludes-eye-condition-naion-very-rare-side-effect-semaglutide-medicines-ozempic-rybelsus-wegovy https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...
- mapontosevenths 2mo agoTo save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes. Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's. I didn't check to see if other studies prove that.
- thrtythreeforty 2mo agoIt is well known that forcing a sudden drop in chronically high average blood glucose (like, from 200+ to a normal ish range) with insulin can cause vision loss. I wonder if it's the same mechanism?
- adam_arthur 2mo agoIt tends to happen when: 1) You must have a crowded optical disc as a precursor (low cup to disc ratio). Genetic and can be tested 2) You have stiff veins/arteries due to poor metabolic/cardio health 3) when blood pressure drops too much, blood flow can get cut off to the optical nerve temporarily due to reliance on high blood pressure due to 2 4) Due to loss of blood flow, optic nerve swells and closes blood flow into the eye due to 1
- Alien1Being 2mo ago"Semaglutide attenuates a proteomics-based dementia risk signature " ie : clinically meaningless. The company behind this, Novo Nordisk is increasingly desperate, as tirzepatide destroys the semaglutide revenue stream and the consequent job losses decimate the company
- Scharkenberg 2mo agoCan you elaborate on your claims? As it currently stands, I’m only reading meaningless drivel from you.
- dghlsakjg 2mo agoTheir operating profit was up 11% on a margin of 44% according to their recent quarterly release, and they beat EPS by 23%. They were in a little trouble in the stock market a few years ago as competitors came online, but they are doing pretty well right now. They have launched new semaglutide oral products which are growing faster than previous products, and they have multiple drugs in the research pipeline in late phases.
- 1970-01-01 2mo agoThat's a big percent for something that is completely devastating. This is objectively good news.
- anonuser123 2mo agoRead a interesting piece recently that Semaglutide reduces inflammation, and very likely the weight-loss and a lot of the other emerging benefits are likely the effects of reduced inflammation.
- Aurornis 2mo ago> and very likely the weight-loss and a lot of the other emerging benefits are likely the effects of reduced inflammation. That’s not correct. GLP-1s interact with satiety (fullness) circuits and reduce appetite. They also have minor effects delaying gastric emptying, meaning the stomach stays full longer. There is some early data suggesting that they might reduce some inflammation markers slightly more than weigh loss alone, but losing weight and controlling food intake without GLP-1s reduces the same inflammatory markers. The question now is if GLP-1s have additional anti-inflammatory influence. I don’t know why someone would claim all of their effects are downstream of inflammation. Some people get stuck in modes where they think inflammation is the cause of everything and can’t comprehend causal effects going in the other direction.
- nwienert 2mo ago> The question now is if GLP-1s have additional anti-inflammatory influence. This is well established, not at all a question. > they might reduce some inflammation markers slightly more than weigh loss alone There's no "slightly," It's going to be a news story for years to come. It's a broad spectrum anti-inflammatory drug of a breadth and efficacy never seen before.
- bgnn 2mo agoCan you please share a good reference on this? All I read about GLP-1 stuff is popular science style punlications. I'm genuinely interested in learning about their benefits over reducing caloric intake, i.e. diet.
- goda90 2mo agoIsn't lower calorie consumption in general correlated to longevity? (Assuming no major malnutrition)
- prescriptivist 2mo agoSure, but there is nothing in the world of the last 30-40 years that can compare to GLP-1s in terms of helping people consume fewer calories. This is a very coarse statement, but I'm confident in making it: there is nothing healthier than being skinny, and GLP-1s make people skinny in a way that is unique in modernity. Our modern food systems are optimized to encourage people to consume as many calories as they can, and GLP-1s are bulwarks against this system, if you will.
- goda90 2mo ago>there is nothing healthier than being skinny Being fit is healthier. Studies support the idea that being overweight but physically active is cardiovascularly healthier than being skinny(GLP-1 or not) and sedentary.
- antonmks 2mo agoAbsolutely magical drug ! It makes you thinner, younger and now smarter !
- mathgeek 2mo agoAlzheimer's disease is not a reduction in intelligence, don't be crass.
- swalsh 2mo agoFor as long as you're on it, but eventually you run out of body fat.
- rootusrootus 2mo agoEven at the max dose you will hit a spot where you stop losing weight before you get anywhere near running out of body fat. Some people even go off label stacking two or more or cranking the dose past officially supported levels because they still are overweight. People honest with themselves will understand that it’s a chronic treatment, you don’t stop.
- londons_explore 2mo agoSo has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.
- a-dub 2mo agothat is the interesting question. also the effects of weight loss vs. the effects of disengagement with the engineered to be addictive "food products" side of the western diet.
- lotsofpulp 2mo agoWhat is interesting about it? Proper sleep, eating less (including liquid calories), and exercising have been the mainstream medical advice for many decades. Obviously, most people can’t accomplish that for whatever reason, so another solution was needed.
- object-a 2mo agoWhat should public health have done differently?
- hattmall 2mo ago
- declan_roberts 2mo agoIf you're overweight or especially if you're T2D I highly encourage you to discuss GLP-1 with your doctor. If you're T2D then get research retatrutide which looks to be an actual cure for T2D by clearing liver fat. It should be released early next year but research-use is available and what everybody is taking. Companies like finnrick do public testing of research peptides and a good place to gather names.
- 01100011 2mo agoSemaglutide cleared my liver fat and fixed my moderate NAFLD in a matter of months. Why is retatrutide necessary?
- brianfryer 2mo agoSemaglutide clears liver fat? I had no idea. I’m curious to know more about your protocol
- 01100011 2mo agoMy protocol was to take semaglutide As a consequence I ate less. Weirdly, I think I eat more sugar now but my total calorie intake is lower. I eat more sugar because sometimes it's the only thing that seems palatable or I'm trying to counteract the hypoglycemia feelings.
- zhivota 2mo agoI have this same reaction sometimes, I don't have the desire to eat a full meal with protein and fat, but a little candy is palatable. It's probably not a good idea overall to be honest, it would be better to just "save up" hunger for a more balanced meal.
- declan_roberts 2mo agoRetatrutide has a specific mechanism for clearing liver fat (glucagon) which makes it one of the most effective ways to treat T2D. This is the 3rd agonist not found in semaglutide or tirzepatide.
- p-o 2mo agoAlthough it's encouraging, they do mention that the reduction in the BMI also have an effect (they take it into the consideration by lowering the β −0.092 to β −0.066 (P < 0.001)). Just skimming through it, it's possible there are direct benefits, but it could also be other environmental factor. This study will most likely generate others that give us more insight in the future.
- deleted 2mo ago[deleted]
- 01100011 2mo agoI'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake several times a night to pee(yeah, prostate is acting up but I still void completely. The semaglutide is like a diuretic for me at night.). I get waves of hypoglycemia like feelings where I feel weak and spaced out. I'm afraid to get off of it because now my joints can't handle the extra weight. My doc recommended going to every other week now that my BMI is normal but as far as I can tell that advice isn't backed up by any research. Anyway, it's a powerful drug that works well but is not without side effects.
- hattmall 2mo agoYou are a proponent, but your outcomes seem worse?
- Juvination 2mo agoLosing 40 pounds where sometimes it feels like this weight is impossible to lose. That's what makes it worth it.
- exhilaration 2mo agoFor a lot of people, the alternative to GLP-1's is dying of a heart attack in their 50s, or taking decades off their lives by developing type 2 diabetes, or any number of complications from weight-related diseases.
- 01100011 2mo agoMy point is that it's not all roses. Overall I'm glad I took it and will continue to do so. It's not without downsides, despite the endless stream of favorable studies on it.
- amrrs 2mo agoIs it kind of the stuff where the benefits outweigh the side effects? I'm just scared of the unknowns with the drug with such overwhelming positive research. Maybe, I'm a paranoid person but I'm unable to believe that such a powerful drug isn't without any side effect, clinically proven.
- bariswheel 2mo agotdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked if the drug turned off the "check engine" light (by measuring blood proteins), rather than testing if the car was actually driving properly (by testing the patients' actual memory and brain function)." Always do FIRST analysis on studies. Or have AI do it for you. I used Gemini to dig into this: "Novo Nordisk funded this study, and several of the researchers are employees or minor shareholders. While corporate funding doesn't automatically mean the data is fabricated, it does mean the company is highly motivated to find and publish data that makes their blockbuster drug (semaglutide, marketed as Wegovy, Ozempic, and Rybelsus) look like a preventative treatment for a wider range of conditions, expanding its market and driving up profits." "Funding: The study was funded by Novo Nordisk A/S. Investigation: Researchers conducted a post hoc analysis using data from the randomized, placebo-controlled SELECT trial. They applied the Dementia SomaSignal Test (dSST)—a 25-protein risk score—to non-fasted serum samples collected at baseline and at week 104 to estimate 5-year and 20-year all-cause dementia risk in patients receiving semaglutide (2.4 mg) versus a placebo. Results: Semaglutide significantly attenuated the progression of the dementia risk signature. Compared to the placebo group, the 5-year predicted risk increased 2.5-fold less (a 26.0% lower predicted event rate) and the 20-year risk increased 1.67-fold less (an 8.8% lower rate). Semaglutide also lowered the odds of patients moving into a higher dementia risk category by 36%. Subjects: The analysis included 2,970 older adults aged 65 and older (mean age of ~69.7 years) who had overweight or obesity and cardiovascular disease, but no history of diabetes. The cohort consisted of 814 women (27.4%) and 2,156 men (72.6%). Time: The study evaluated data over a 104-week (2-year) follow-up period. The analysis was published on August 8, 2026." And then map the weakness to each respective letter if you want to dig deeper.
- TheBlight 2mo agoDidn't even bother looking into it because there's obviously not enough data yet to say anything substantial about GLP-1s and Alzheimers. But your comment should probably be the top.
- pranav_tech26 2mo ago[flagged]
- rimeice 2mo agoin older adults *with obesity *and cardiovascular disease without diabetes
- moresVanpersi 2mo ago[dead]
- miki123211 2mo agoI swear, Semaglutide is reverse Asbestos. It's something we found and started using to one specific problem, but it later turned out that it has lots of other, extremely wide-ranging consequences. Except that in this case, these consequences are positive.
- amelius 2mo agoSemaglutide reduces appetite. Who could have known that eating less will have positive effects? Maybe we should try consuming less in general and see what the effects are. Is there a semaglutide for my shopping habits? Maybe ban ads?
- bitexploder 2mo agoGLP-1 does a lot more than just stomach signaling. It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency similar to if you were to do endurance work/cardio. There's a lot going on with it. That's kind of what the parent is talking about, all these second-order effects that were not obvious. There is also evidence of down-regulated mTOR signaling and epigenetic protection. And these aren't all just bullshit, big pharma funded studies either.
- amelius 2mo ago> It shrinks visceral fat, it's been shown to clear liver fat The brain is 60% fat, so I'm not running to the pharmacy yet.
- juiceland 2mo agoMyelin and membranes aren’t triglyceride stores. There’s no lipolytic pathway that strips a neuron’s membrane the way a caloric deficit empties an adipocyte.
- swalsh 2mo agoCalling it now, the downside is the effects are most apparent on higher dosages, but you cant take higher dosages forever. Eventually you run out of body fat, have go reduce the dose, and the benefits dither.
- jtrn 2mo agoI'm a strong proponent of GLP1. But a change in one marker is at best an okay signal. But the only thing one cares about is real changes in rates. Who cares about markers that don't translate to real clinical outcomes. That's the whole damn problem with everything from stupid "this makes you younger" claims and the tragedy that is the history of Alzheimer research. I wish they compared straight-up weight loss without disease. In this specific population, the bias has a known direction: unintentional weight loss in older adults is a well-documented dementia prodrome = weight starts dropping years before diagnosis. So placebo-arm weight losers are enriched for people already on the downward trajectory, and any comparison matched or adjusted on BMI change-diff inherits that, making the drug look better than it should in this study design. And the 5-year OR 0.74, and no BMI-adjusted coefficient is given for it. The 5-year calibration is dominated by near-term inflammatory/metabolic pathways — exactly what weight loss moves, so it plausibly attenuates much more than 28%. I think the conclusion is not warranted at all: that semaglutide does more than its weight loss explains, not the same or less. Which is also the commercially valuable claim. And note that Novo funded the study, AND two authors are Novo employees/shareholders. In short, I like GLP1s, but I'm not convinced by this study that GLP1 treatment reduces dementia incident rates meaningfully compared to normal health weight loss.
- fkdupman 2mo agoReading about GLP-1 medications reminds me of the movie Limitless. Being on them sounds great, getting off of them not so much.
- paulpauper 2mo agonot really. these drugs only merely make you not overweight or obese, which was normal until around 1980 or so.
- ShinyLeftPad 2mo agoThe study implies it also does other stuff though. That's the thing
- overgard 2mo agoSome researchers have (informally) taken to calling certain forms of dementia "type-3 diabetes", so I think this sounds at least plausible. It's far from a foregone conclusion or anything, but there's at least some evidence that dementia might be a metabolic issue, so it would make sense that something that improves metabolic health would also improve brain health.
- esseba-dev 2mo ago[flagged]
- pessimizer 2mo agoThis is one of those fake stats, where if among people not taking it you would see 4 out of 100 get dementia within 5 years of when you started measuring, if they were taking it you'd instead see 3 out of 100 get dementia within 5 years, and the number is either a projection ("predicted risk") because they didn't actually study it for 5 years, or the number is a p-hack because they checked every possible thing they could with the 5-year data they had and this was the only interesting thing that they found ("post hoc analysis"), or both (the projection of a p-hack), which I suspect because they also tell you about the 20-year risk, and it is a study sponsored by the manufacturers of the drug, being suggested to cure a disease diagnosed by checklist (rather than any physical test.) Will that keep it out of the headlines? No, it was written to become a "free" ad that will be published by the people they send enormous amounts of money to, but by their "news" departments. The best thing we can do for the progress of medicine in the US is to make direct-to-consumer advertising of prescription drugs illegal again. There would be no use for this if the media hadn't been bribed to become cheerleaders for any old shit. It's illegal everywhere in the world other than the US and New Zealand.
- TMWNN 2mo ago[dead]
- enquirewithin 2mo agoAnd a doubling in the rate of waking up blind.
- juiceland 2mo agoDoubling doesn’t mean much without knowing the base rate.
- JimRoepcke 2mo agoSemaglutide reduces appetite. The less appetite you have the less you eat crap. The less crap you eat the healthier you are. There's a little more to it than that obviously but this is the reason that they're finding all these "unexpected" things improving when people take semaglutide. Most food eaten by most people with access to semaglutide is crap, that makes you unhealthy. Eating less crap improves lots of factors. But the good news is, eating less crap makes you less unhealthy independent of other factors too.
- pranav_tech26 2mo ago[flagged]
- jimkleiber 2mo agoI hope that people will study the emotional impacts of these drugs. I wonder if that may be the root of a lot of these changes we are seeing and might provide more clues into what might be possible with them.
- pagutierrezn 2mo agoBetter summary: Two years of semaglutide treatment appears to substantially slow the worsening of a blood protein signature associated with future dementia risk
- cloudie78 2mo ago[flagged]
- NeoVIs 2mo ago[dead]
- deleted 2mo ago[deleted]
- Lagoon3384_SWE 2mo agoVery american thread and comments. At most I was 24 BMI and I felt like a fat bastard during COVID. Work from home in sweatpants and I got up to 24 BMI. 77-78kg, 182cm. I just did not weigh myself so I actually did not notice I had gained! But I did and decided to do something about it. But I lost the weight pretty quickly. I grew up at 60-65kg and that is where I feel at home in my body. I feel like myself basically. I should add I am 35, so certainly no spring chicken. "omg how did you lose it" Very easy. 1. Weight loss is done through diet, not exercise. Exercise is great for the body, but not a primary weight loss. 2. If you work an office job you do not need 3 full meals a day. Eat a light breakfast, a full lunch and a light meal for dinner. 3. On the weekends, fast. If you are committed, this weekend, buy like 4-5 litre of sugar free/diet soda, flavoured water zero calories, and caffeine pills. To distract yourself, play a high dopamine grind game like Diablo IV, PoE, Borderlands, WoW/FFXIV, CS, Valorant etc. Just drink, do not eat. Hunger is temporary and will last like 1h for me, then the body "gives up". Do a 24h or 48h water fast, you will drop 5kg easy and feel way less bloated. Repeat next weekend... Set an alarm every 2-3h to get up and walk. Get your 10k steps in everyday by walking outside. "omg that's unhealthy" Yes, ofc but it is more healthy than being overweight or close to overweight, agreed? "you can only do this because ur a Swedish chad and you have walkable cities!!" I'm a degenerate gamer. lol
- david-gpu 2mo agoI used to be similarly judgemental and flippant when my BMI was 20~21 in my 20s and 30s. My health took a few wrong turns and I now have a BMI of 30. My diet is just as good, if not better, than back when I was slim. But now my sleep is worse, I tire much more easily, recover much worse from exercise, and, crucially, I am much hungrier. I no longer preach how simple it is to maintain a healthy weight. I should have known better back then and kept my mouth shut.
- Lagoon3384_SWE 2mo agoI should add I am 35 and male, so certainly no spring chicken! I haven't slept a full night in years due to having to get up and pee or waking up for some reason. Maybe sleep apnea but I haven't bothered to get it checked. My diet is like crap, I eat junk food, sandwiches and chips and zero calorie soda. Still 19-21BMI now as I weigh myself daily to keep in check. And having been 24BMI back down to 19-20BMI, I know it can be done and how to do it. Maybe if I am 55 it will get harder sure. But I just dont get as much dopamine from eating as others I guess. As the thinspo girls on TikTok, Youtube say "Eating is not the main event." Thank you for commenting as I notice a lot of people just downvote or think I am trolling, but I am honest here but I dont express myself very well. I am cought between two worlds, I am not smart enough to be here really, but not dumb enough to start commenting on TikTok. I belong on 2009 Reddit but that Reddit is long gone... thanks for letting me ramble. Hope the mods dont come and get me again.. u.u
- hnmuuatsno 2mo ago[dead]
- tsoukase 2mo agoDiabates can harm the brain either indirectly, through vascular damage, or directly through nerve cell degeneration. The latter is a less studied mechanism and can explain the benefit from GLPs. But I agree, it's not different than a low calorie diet. In the modern times of abundance and sedentary lifestyle, fasting makes wonders. So, if you have even one vascular risk factor, just cut your calories in half, just stop eating. Your body will thank you.
- anovikov 2mo agoGLP-1 provides the only plausible way to do so.
- dripdry45 2mo agoThis is just flat out untrue. Going a day or two without eating anything feels freeing and wonderful. You simply have some coffee and go through your day, drink water. By not eating anything at all it’s much easier. Even having a couple bites of food gets the body revved up to eat more. Fasting is a choice to simply not. To abstain. To stop and pause. This idea is so un American that I believe people are simply unaware and unable to process the notion. Putting this idea in people’s mind, that they will be OK if they don’t eat for a day, would be revolutionary. However, companies want to sell things rather than simply give people a basic idea and open their world to possibilities.
- anovikov 2mo agoThis simply isn't how any addiction works. You can just as well say to an alcoholic to "just stop drinking". Humankind tried to rid itself of obesity for too long and it only kept getting worse. GLP-1 is the key.
- tsoukase 2mo agoLet's not be absolute. There are some people craving for food (esp. endomorphs), some binge eaters (eg under depression) or low metabolizers (hypothyroid) but for many it's easy to cut calories.
- catchcatchcatch 2mo ago[dead]
- pkilgore 2mo agoDidn't EVOKE fail at the primary endpoint of reducing dementia? Sure, they hit a fucking surrogate, that's sometimes interesting for additional research. But we have incredibly strong clinical evidece oral semaglutide did not significantly reduce clinical progression in patients with early symptomatic Alzheimer's disease.
- glp1_dose3 2mo ago[flagged]