wdewind

10 ms·

31.
by wdewind 8y ago
My experience is the IRS telling me I owe them $20,000, me calling them three separate times and having estimated wait times of over 3+ hours each time, finally just giving up turning it over to my accountant, who charged me $400 to find ou
32.
by wdewind 8y ago
> It's doesn't say that one can control people weigth using CI. It absolutely says that. Absent other factors changing, a reduction in caloric intake will result in a weight loss. It does not disagree with there also being ot
33.
by wdewind 8y ago
Not sure why you're being downvoted, and I appreciate you finding studies. > Humans, difference in body composition: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645638/ So this study is actually not
34.
by wdewind 8y ago
> You are implicitly assuming that CO will be constant and would be independent of CI... We do not know that to be true. No, we can reason about this fairly easily knowing the extraction costs of calories from macronutrients. You'r
35.
by wdewind 8y ago
Also you can't drink gasoline, which has a ton of calories, straight up, so CICO is bullshit. But to steel man your argument: yes, macronutrient composition obviously matters, but you can lose weight with a low calorie diet of any comp
36.
by wdewind 8y ago
> Yeah, welcome to medicine. If you've ever encountered these things in a non-theoretic perspective (i.e., having some condition), you quickly see that doctors don't know shit. That is, unfortunately, exactly why I am so acquai
37.
by wdewind 8y ago
> CICO and the fact that distribution (both in time and macro) of the calorie in matter can both be true. Maybe they do matter somewhat, but here's the deal: if everyone who was obese in this country all of a sudden started eating a
38.
by wdewind 8y ago
> Do you think this hormonal response has no impact on weight loss (or, for that matter, muscle gain)? That's way too broad a statement for me to blanket agree or disagree with. Short answer: no I definitely don't think that.
39.
by wdewind 8y ago
I think what he's asking for is long term epidemiological studies, which are hard to come by. I'd have to see the studies you are referring to, but most likely they refer to measurements occurring over a relatively short time per
40.
by wdewind 8y ago
> Yes, calorie-restriction works in basically every living thing to prolong life. No, people will not do it. Right, this is the point: it's about compliance, which is real and important, but very different from metabolic change. &gt
41.
by wdewind 8y ago
> It’s obviously not true that for any given set of calories consumed the body has only one option of what to do with them. It can build muscle, store fat, repair heart walls, excrete it, and so forth. Yep, I would not suggest anyone tak
42.
by wdewind 8y ago
> Any resource to validate this claim. Most IF studies do not show any metabolic difference, and the ones that do do not control for calories. I'm sorry to shift the burden of proof, but I feel like CICO is the default position and
43.
by wdewind 8y ago
> It sounds like your conclusion is roughly that, sufficient nutrients aside, it doesn’t make a damn bit of difference which columns the calories are under, not just in terms of weight management, but general health. My conclusion is tha
44.
by wdewind 8y ago
Yeah, this is actually a great question imo. So the main problem would be nutrient absorption, and there would be a number of problems that would impact it, from literal surface area of your digestive system, to current bacterial population
45.
by wdewind 8y ago
> It's far too simplistic to argue that it's the average insulin intake that matters. I agree, I'm trying to more accurately state what we confidently know based on the available science, rather than what might be true bas
46.
by wdewind 8y ago
> No, diabetics have an elevated insulin levels for hours after a meal. Like, after 4 hours it's still at the level a non-diabetic peaks at after 0.5-1 hour. Eating many meals will keep your insulin levels high all-day. I have repea
47.
by wdewind 8y ago
> How can fat elevate blood sugar levels? Via gluconeogenesis, but it is, for sure, less effective than protein based gluconeogenesis. > If you don't have elevated blood sugar from eating a bunch of carbs, what effect does insuli
48.
by wdewind 8y ago
It's the same idea: talking about spikes vs average. Calories is what matters. Yes, insulin and inflammation can be linked, but also you wont have excess of either on a calorically controlled diet. Interestingly context can totally r
49.
by wdewind 8y ago
> Yes, but your body won't be able to use it's stored fat in the presence of insulin. If you keep that up long enough, you can only burn calories coming in. If you eat a lot of meals AND a caloric deficit your body needs to dec
50.
by wdewind 8y ago
If you have any that disambiguate between average and peak blood glucose levels I would be really interested in reading them! To my knowledge no one is really studying this because it is hard and if you are successful proving that knowledg
51.
by wdewind 8y ago
You have to be more specific. T1 diabetes is almost entirely genetic, T2 diabetes is almost entirely behavioral. T2 diabetes is caused by eating too many calories. T2 diabetes is reversed by constraining calories, regardless of macronutr
52.
by wdewind 8y ago
> My blood ketones during my fasting are through the roof, over 1.5 mmol/L after 15 hours of fasting, which indicates deep nutritional ketosis and an indication that lypolisis is efficient. The problem is that there isn't any r
53.
by wdewind 8y ago
I'm sorry to just repost my paragraph from above, but I believe I already responded to this: > The IF people (along with the Keto people) use a variety of tricks to try and prove their point. There is absolutely not a single paper
54.
by wdewind 8y ago
> In other words, should we all just be eating as if we were diabetics? I assume you mean low glycemic load. I don't think so. I think we should all focus primarily on eating the right number of calories, and the behaviors that ge
55.
by wdewind 8y ago
Yes, I want to point out that diabetics react differently and really do have to manage insulin, it's the idea that metabolically healthy people also have to that is a red herring. Obesity is not an insulin disorder just because insuli
56.
by wdewind 8y ago
> Sorry for the dumb question, but given the total calories are the same, does this mean that it is generally healthier to eat one big meal per day rather than 10 small ones? We can't answer this confidently, the way I would say it
57.
by wdewind 8y ago
> Unless, of course, the human body historically faced strong selective pressures to efficiently store energy when you have to eat a lot at once. Right, and the intermittent fasting crowd uses the same tricks as Gary Taubes but in revers
58.
by wdewind 8y ago
This actually makes a ton of sense and is what people on the sidelines of the insulin debate have been screaming since Gary Taubes starting publishing his work about dietary sugar. Unfortunately it's given people a very non-nuanced vi
59.
by wdewind 8y ago
> The link between insulin and aging is super well understood. This is really overstated. The paper is a paper on round worms, which is really one step above basic cellular science (which is important but only a building block of the w
60.
by wdewind 8y ago
> Indeed, you use a burndown chart to know how the current sprint is going. Don't wait until the end of the sprint to know you're late, detect problems early. I don't know how this is different from what I said and my poin

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