> Yes, calorie-restriction works in basically every living thing to prolong life. No, people will not do it. Right, this is the point: it's about compliance, w

> Yes, calorie-restriction works in basically every living thing to prolong life. No, people will not do it. Right, this is the point: it's about compliance, which is real and important, but very different from metabolic change. > Please don't tell me there is conclusive evidence on anything related to nutrition. The second statement is not true, differences have been shown. No, there is no study showing the same number of calories consumed over different feeding schedules have any different outcomes. I am 100% confident about this. To be clear: there are studies showing people on IF eat fewer calories, and that eating few calories has net benefits. That's great, but that's compliance not metabolism. > Yes, it's not binary, but the easy way to increase lipolysis is to decrease insulin. Again, time windows. Please consider time windows. In a 24 hour period this stuff is all neutralized. Or maybe it's not, but we don't have any science showing it's not, and quite a bit showing it is.