> It's far too simplistic to argue that it's the average insulin intake that matters. I agree, I'm trying to more accurately state what we confidently know bas

> It's far too simplistic to argue that it's the average insulin intake that matters. I agree, I'm trying to more accurately state what we confidently know based on the available science, rather than what might be true based on our hunches. Insulin spikes being bad are 100% in hunch land. > The complex kinetics depends both on rate as well as average / basal dosages. I agree but, again, very little science that disambiguates effectively. > Spikes can trigger different biological responses that respond to thresholds and equilibria. Right, this is what the basic science has shown, but what we don't know is what difference this makes within a 24 hour window, or epidemiologically over time. > It's a differential problem, and the answer isn't easy. Definitely agree.