sradman

53 ms·

451.
by sradman 6y ago
> When a modern ichthyologist examined the book a quarter millennium after its publication, he determined that only about one in ten of the species depicted was drawn from the imagination; the rest were identifiable down to the genus, ma
452.
by sradman 6y ago
> Our farmers work hard to ensure ducks and drakes are separated correctly. As a result of this difficulty in sexing, a male white-feathered duck may very occasionally be left with a group of females, although, these instances are extrem
453.
by sradman 6y ago
Martin Kleppmann applies critical thinking to the claims of NoSQL marketing; I wish I was aware of his work at the time. I always found it frustrating that the semantics of the word "Consistent" in ACID has nothing to do with the
454.
by sradman 6y ago
Interview with the same journalist: DarkHorse Podcast with Nancy Rommelmann and Bret Weinstein [1]. [1] https://www.youtube.com/watch?v=IfT_APUnp30
455.
by sradman 6y ago
A nice short list of design principles/techniques. I'd also recommend The Design of Design [1] by Fred Brooks (of The Mythical Man-Month fame). The article's final "Postpone Complexity" principle reminded me of
456.
by sradman 6y ago
The paper Multisystem inflammatory syndrome in children: A systematic review [1]: > The literature reports that MIS-C typically manifests 3-4 weeks after SARS-CoV-2 infection. This may explain why many children had positive antibodies
457.
by sradman 6y ago
We have "flying cars": they are called airplanes and helicopters. The latest trend is towards a hybrid vehicle that combines the Vertical Takeoff and Landing (VTOL) capabilities of a helicopter with the forward speed and efficienc
458.
by sradman 6y ago
The closing lesson: > forget grand ideologies and others’ models. There is no replacement for experimentation, independent thought, and ruthless pragmatism. The trick is distinguishing between what is truly pragmatic and not merely ruthl
459.
by sradman 6y ago
The client-side script.js [1] appears to have a hard coded list of well known STUN/TURN endpoints, some with credentials. The identity and access management is non-existent at this point of the project’s roadmap. A client needs the hos
460.
by sradman 6y ago
> Serum 25OHD concentrations at baseline or during treatment are not available. This is mind boggling. These 76 patients had extensive blood work done so why did the study design not include serum concentration testing before and after t
461.
by sradman 6y ago
The paper Interspecies Microbial Fusion and Large-Scale Exchange of Cytoplasmic Proteins and RNA in a Syntrophic Clostridium Coculture [1]: > Here, transmission electron microscopy and electron tomography demonstrated cell wall and mem
462.
by sradman 6y ago
Bret Weinstein's doctoral thesis Evolutionary Trade-Offs: Emergent Constraints and Their Adaptive Consequences [1] describes the hypothesis. Telomere length limits the number of times a cell can replicate so longer telomeres hold the
463.
by sradman 6y ago
The paper Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice [1]: > We find that CaAKG promotes a longer, healthier life associated with a decrease in levels of systemic inflammatory
464.
by sradman 6y ago
ACE and ACE2 [1] work in tandem: > ACE2 counters the activity of the related angiotensin-converting enzyme (ACE) by reducing the amount of angiotensin-II and increasing Ang(1-7) The cell/tissue tropism of SARS-CoV-2 must logically h
465.
by sradman 6y ago
Yesterday's Lexicon Valley podcast by John McWhorter [1] The Incredible Story of the Traveling Creole is very timely: > Enslaved people developed a hybrid language that sailed from Africa to the Caribbean and—unbelievably—back a
466.
by sradman 6y ago
I think the race is not to “Save” pidgins and creole languages but instead to fully document them. These languages represent a unique natural experiment that will probably not occur again. Studying them provides insight into how the languag
467.
by sradman 6y ago
> Feline infectious corona peritonitis (FIP) is the name given to a common and aberrant immune response to infection with feline coronavirus (FCoV). [1] Sounds like it is primarily a gastro-intestinal disease. EDIT: > An experimental
468.
by sradman 6y ago
The paper [1] Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer : > Here, we demonstrate that honeybee venom and its major component melittin potently induce cell d
469.
by sradman 6y ago
Why would spike binding matter for a protease inhibitor that works within the cell? Regardless, human kidney organoids with ACE2 receptors are available [1] so the question switches to why the human kidney organoid people don't coordin
470.
by sradman 6y ago
The paper describes a protease inhibitor [1] that was previously developed for cats: > Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based prot
471.
by sradman 6y ago
Log shipping works well for single master scenarios and these solutions can be combined with a partitioned primary key space for inserting new rows in the remote databases. A two-way embedded/server relational sync is a much more diffi
472.
by sradman 6y ago
> The idea was born from a mistake. One night near Death Valley, California, Wu set a camera to make a time-lapse series in the dark. A pickup truck drove by and washed out the scene with its harsh headlights. > At first, says Wu, “I
473.
by sradman 6y ago
The capital of Indonesia is moving from Jakarta on the island of Java to a newly designed city in East Kalimantan (Indonesian Borneo) [1]. This article is about the winning entry for the design of the proposed city. Jakarta is susceptible t
474.
by sradman 6y ago
Winning a negative-sum game is a pyrrhic victory [1]. Charitably I'd call Larry Ellison very competitive but the uncharitable description is cut-throat (i.e. Machiavellian). Enterprise software sales is a naturally zero-sum game and El
475.
by sradman 6y ago
> never intended or designed to take advantage of ground-effect This is a bit of a circular argument. How do you incorporate real-world empirical data in your design before you have a real-world prototype? The ground effects phenomena wa
476.
by sradman 6y ago
From the bullet points that start the article: > The Soviet Union was the only country to experiment with such a craft, and Russia abandoned the effort after the Cold War. I think it could be argued that the Spruce Goose [1] was an early
477.
by sradman 6y ago
> population and land-use patterns... are two of the most important variables in any TDM [Travel Demand Model] All models are based on assumptions. Revisiting those assumptions should be a continuous process that forms a tight feedback l
478.
by sradman 6y ago
2018 article and paper [1] suggesting that the Dark Triad [2] of personality traits, comprised of narcissism, Machiavellianism, and psychopathy, can be generalized into a D-factor similar to the g-factor in intelligence. From my persp
479.
by sradman 6y ago
Boston Dynamic's four-legged Spot [1] and bipedal Atlas [2]. Agility Robotic's Digit [3]. It looks like robotic actuators are about to hit an innovation wave. [1] https://www.bostondynamics.com/spot [2] https:&#x
480.
by sradman 6y ago
Atlantic article A New Era of Coronavirus Testing Is About to Begin [1]. Compared to Michael Mina's ideal "lick-a-stick" $1 saliva test, the Abbott BinaxNOW: - costs $5 per test/card - uses a nasal swab (less intrusive

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