3 ms·
The paper describes a protease inhibitor [1] that was previously developed for cats: > Feline infectious peritonitis, a fatal coronavirus infection in cats, wa
by sradman 6y ago
The paper describes a protease inhibitor [1] that was previously developed for cats:
> Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based protease inhibitor.
GC376 and its precursor GC373 "...are potent inhibitors of SARS-CoV-2 replication in cell culture." Since these drugs are safe in cats, it gives hope for safety and efficacy in human trials.
An effective treatment of SARS-CoV-2 (and other coronaviruses) complements the vaccine effort.
[1] https://en.wikipedia.org/wiki/Protease_inhibitor_(pharmacology) https://en.wikipedia.org/wiki/Protease_inhibitor_(pharmacolo...