2 ms·
The paper Multisystem inflammatory syndrome in children: A systematic review [1]: > The literature reports that MIS-C typically manifests 3-4 weeks after SARS
by sradman 6y ago
The paper Multisystem inflammatory syndrome in children: A systematic review [1]:
> The literature reports that MIS-C typically manifests 3-4 weeks after SARS-CoV-2 infection. This may explain why many children had positive antibodies to SARS- CoV-2, but negative RT-PCR at the time of MIS-C evaluation.
> While children with COVID-19 present with upper respiratory symptoms, MIS-C is distinguishable by fever (100%), vomiting (68.2%), and abdominal pain/diarrhea (73.8%). The abdominal pain in MIS-C can be so severe that in several cases patients were presumed to have appendicitis.
Young children seem to be protected from lower respiratory manifestations of COVID-19. My reading of this meta-analysis is that MIS-C is primarily a gastrointestinal manifestation of COVID-19 that has progressed to vascular and other tissues that express ACE2 receptors.
Perhaps we are placing too much emphasis on nasopharyngeal swab PCR tests and should consider anal swabs for children with gastrointestinal symptoms.
[1] https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30271-6/fulltext https://www.thelancet.com/journals/eclinm/article/PIIS2589-5...