The paper Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice [1]: > We find that CaAKG promotes a longer, h

The paper Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice [1]: > We find that CaAKG promotes a longer, healthier life associated with a decrease in levels of systemic inflammatory cytokines. Judging from the image of black mice in the article, the C57BL/6 strain of lab mice [2] are used in the study. This strain has long telomeres which should be taken into consideration with all the other caveats associated with longevity studies in mouse models. If you are an optimist, then the hypothesis that AKG [3] supplementation safely reduces age related systemic inflammation is a positive outcome. [1] https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30417-4 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)... [2] https://en.wikipedia.org/wiki/C57BL/6 https://en.wikipedia.org/wiki/C57BL/6 [3] https://en.wikipedia.org/wiki/Alpha-Ketoglutaric_acid https://en.wikipedia.org/wiki/Alpha-Ketoglutaric_acid