soudiere

9 ms·

31.
by soudiere 3y ago
The researcher looked at depression in their 2022 paper, it was not statistically significant, agreed it's odd they didn't mention. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8864418/
32.
by soudiere 3y ago
Two of the researchers datasets were from 2012-2016 and 2018-2019, I can't find the full text of the third study with 171 participants. Likely pre-tiktok. What's real interesting is their 2021 paper, showing the effect is mediated
33.
by soudiere 3y ago
This idea is not my own, it's something discussed in the clinical literature. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ There is literature documenting a higher incidence of allergies in pati
34.
by soudiere 3y ago
There's a wide variety of bacteria that inhabit the GI tract, with tremendous diversity around the world. The extinction idea is interesting, but I've not seen any evidence that demonstrates anything like it in the literature. ht
35.
by soudiere 3y ago
No. Allergies and Auto-immunity are both pathologies of the adaptive immune system "incorrectly" targeting things. Regulatory t cells, "tregs", modulate this. https://www.jacionline.org/article/S0091
36.
by soudiere 3y ago
It's not a 20-50% success rate, this isn't a 2 week antibiotic course. Frew (2006) is one of the larger trials, two treatments, one group worked up to dosage of 10k, the other 100k. Higher dosage group had better measures of impro
37.
by soudiere 3y ago
Allergies and auto-immune disorders are "expressions" of the same underlying process. Dysfunction in regulatory t cells, part of the adaptive immune system that "trains" the adaptive immune system on what to "attack
38.
by soudiere 3y ago
Your reasoning is erroneous. "Humans do not produce lactase, ergo it's false milk is fundamental/crucial". Humans do not produce the enzymes to digest some dietary fiber, ergo it's not fundamental/crucial. The
39.
by soudiere 3y ago
There are a couple other second generation antihistamines for you to take a look at. If you're having CNS effects, focus on the receptor binding affinity for anything besides H1 (also look at metabolites). https://sci-hub.se
40.
by soudiere 3y ago
It's not that challenging. We have a decent understanding of tregs (regulatory T cells) and their role in allergy https://en.wikipedia.org/wiki/Regulatory_T_cell "Short-chain fatty acids (SCFAs), which are ge
41.
by soudiere 3y ago
Start with this review article in 1989, allergy shots for hay fever are well studied and quiet effective. https://sci-hub.se/https://www.tandfonline.com/doi/abs/10.10... "Success rate is 20-50%
42.
by soudiere 3y ago
Great point, agreed, viral re-activation seems suspect on causality. I was suggesting to crossreference Valtrex effectiveness against the activated virii in the study I linked. If Valtrex is not effective against the reactivated cohorts, we
43.
by soudiere 3y ago
Doctor isn't writing a prescription for exercise, they're suggesting you work towards performing more of it because the best (limited) clinical evidence we have suggests it helps.
44.
by soudiere 3y ago
Discussion is more nuanced This study screened for active vs latent on number of viruses in patients vs assumed health controls, bottom chart here is what you would evaluate Valtrex effectiveness against. https://translational-me
45.
by soudiere 3y ago
"Tried to force them to exercise ... ignores all the science and evidence" This is a baseless claim, there's a Cochrane review showing exercise is beneficial. Pacing appears to be a common strategy, and it's exercise in
46.
by soudiere 3y ago
Post-exertional malaise is a poor diagnostic indicator, the sensitivity and specificity are quite low. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7988339/ First problem, I do not have ME/CFS, let'
47.
by soudiere 3y ago
All exercise excerbates ME/CFS? Only certain types? Cochrane systemic review, "exercise therapy for chronic fatigue syndrome", 8 studies, 1518 participants "Investigators compared exercise therapy with 'passive&#x27
48.
by soudiere 3y ago
Nope, definitely hate Jira.
49.
by soudiere 3y ago
"interaction of dopamine and acetylcholine systems in the rat ... to direct D-amphetamine administration ... The increases observed during amphetamine ... were both blocked by co-administration with the D1 antagonist ... but not with t
50.
by soudiere 7y ago
Ah apologies, yes her revisiting of the original paper does not address many of the issues raised.
51.
by soudiere 7y ago
It's not sophisticated logic, it's plain reading of the grammatical structure of the phrase. An adverb and adjective modifying a noun. Haraway did not play a few games of chess as a child, she studied 7+ years to get a PhD. I&#x27
52.
by soudiere 7y ago
Link me Haraway's PhD thesis please, I can't find it on scihub. Original assertion was "highly credentialed biologists", which is different than "highly credentialed in biology", and I would agree with your obj
53.
by soudiere 7y ago
I referenced the original 1993 essay "The Five Sexes" You have referenced the 2000 essay, "The Five Sexes, Revisited" No on claimed it was a scientific investigation, I quoted the full text of the issue I was discussing
54.
by soudiere 7y ago
I am addressing a specific claim she made in her paper, quote in full. "Not surprisingly, it is extremely difficult to estimate the frequency of intersexuality, much less the frequency of each of the three additional sexes: it is not t
55.
by soudiere 7y ago
Yet somehow she got a PhD in biology from Yale with it, we should probably read it before judging it as "a biology paper" or "not a biology paper". Feel free to list some highly credentialed social scientists you respect
56.
by soudiere 7y ago
I will give it a read. Fausto-Sterling seems to be loose with data. In The Five Sexes she cites Money as the source for upwards of 4% of the population being intersexual. Money denied the claim here (last page) https://www.resear
57.
by soudiere 7y ago
Haraway has a PhD in Biology from Yale.