19 ms·

Allergies and auto-immune disorders are "expressions" of the same underlying process. Dysfunction in regulatory t cells, part of the adaptive immune system that

Allergies and auto-immune disorders are "expressions" of the same underlying process. Dysfunction in regulatory t cells, part of the adaptive immune system that "trains" the adaptive immune system on what to "attack". https://en.wikipedia.org/wiki/Regulatory_T_cell https://en.wikipedia.org/wiki/Regulatory_T_cell

pfannkuchen 3y ago
Sure, in the same way that busses and porcupines are expressions of the same underlying process. There are also some key differences, or else we would expect a similar prevalence of autoimmune disease as allergies, no?
- soudiere 3y ago
  No. Allergies and Auto-immunity are both pathologies of the adaptive immune system "incorrectly" targeting things. Regulatory t cells, "tregs", modulate this. https://www.jacionline.org/article/S0091-6749(16)30499-7/fulltext https://www.jacionline.org/article/S0091-6749(16)30499-7/ful...
  - pfannkuchen 3y ago
    My point is that while there may be some broad commonality (with physics being a hyperbolic commonality in the example I gave), this does not mean that there are no differences and that we can always infer information about one from information about the other (though in some cases we can).
    - soudiere 3y ago
      This idea is not my own, it's something discussed in the clinical literature. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ There is literature documenting a higher incidence of allergies in patients with autoimmune disorders. https://erj.ersjournals.com/content/54/5/1900476 https://erj.ersjournals.com/content/54/5/1900476 BACH2 is one of the gene's being investigated for it's role in allergies & auto-immune disorders, and tregs, which is why I keep bringing them up on this thread. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/
      - pfannkuchen 3y ago
        I think what you are implying above is that we can take a study or survey about autoimmune disease and use it to make conclusions about allergies. All I am saying is that this does not logically follow, because the two are not the same and “allergy” is not a strict subclass of “autoimmune disease”. The specific details of the mechanism are not relevant to the logical point unless those details establish a subclass or identity relationship (which here they do not).

pfannkuchen 3y ago

Sure, in the same way that busses and porcupines are expressions of the same underlying process. There are also some key differences, or else we would expect a similar prevalence of autoimmune disease as allergies, no?

soudiere 3y ago
No. Allergies and Auto-immunity are both pathologies of the adaptive immune system "incorrectly" targeting things. Regulatory t cells, "tregs", modulate this. https://www.jacionline.org/article/S0091-6749(16)30499-7/fulltext https://www.jacionline.org/article/S0091-6749(16)30499-7/ful...
- pfannkuchen 3y ago
  My point is that while there may be some broad commonality (with physics being a hyperbolic commonality in the example I gave), this does not mean that there are no differences and that we can always infer information about one from information about the other (though in some cases we can).
  - soudiere 3y ago
    This idea is not my own, it's something discussed in the clinical literature. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276104/ There is literature documenting a higher incidence of allergies in patients with autoimmune disorders. https://erj.ersjournals.com/content/54/5/1900476 https://erj.ersjournals.com/content/54/5/1900476 BACH2 is one of the gene's being investigated for it's role in allergies & auto-immune disorders, and tregs, which is why I keep bringing them up on this thread. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710737/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934237/
    - pfannkuchen 3y ago
      I think what you are implying above is that we can take a study or survey about autoimmune disease and use it to make conclusions about allergies. All I am saying is that this does not logically follow, because the two are not the same and “allergy” is not a strict subclass of “autoimmune disease”. The specific details of the mechanism are not relevant to the logical point unless those details establish a subclass or identity relationship (which here they do not).