"interaction of dopamine and acetylcholine systems in the rat ... to direct D-amphetamine administration ... The increases observed during amphetamine ... were

"interaction of dopamine and acetylcholine systems in the rat ... to direct D-amphetamine administration ... The increases observed during amphetamine ... were both blocked by co-administration with the D1 antagonist ... but not with the D2 antagonist" https://pubmed.ncbi.nlm.nih.gov/9881866/ https://pubmed.ncbi.nlm.nih.gov/9881866/ New paper models psychosis by administering amphetamines to mice, and concludes the D1 receptor is more important in psychosis. Relative binding affinities for D1 and D2 of many antipsychotics shown here https://www.cambridge.org/core/journals/cns-spectrums/article/drugs-for-psychosis-and-mood-unique-actions-at-d3-d2-and-d1-dopamine-receptor-subtypes/1141A0DF13B78B1157ED2020276CA171 https://www.cambridge.org/core/journals/cns-spectrums/articl... There are already 3 antipsychotics on the market that have a D1 binding affinity that is an order of magnitude higher than D2.