searine

31 ms·

361.
by searine 9y ago
> Given that, what do you suggest they should have done Not used the term positive selection. If they hadn't done that this would have been boring, but fine.
362.
by searine 9y ago
>This is setting the bar rather high, no? I understand what you are saying, but "signatures of positive selection" has a very specific technical definition and associations are not it. It means allele fixation in a population d
363.
by searine 9y ago
Poor wording. The idea that autism-related variants convey intelligence is speculative.
364.
by searine 9y ago
Speaking as an evolutionary genomicist, you shouldn't read much into this result for the following reasons : 1. The authors only show an association between phenotype (autism) and a rare genetic variant. They do not prove any kind of a
365.
by searine 9y ago
>a lot of companies think they need XYZ, but in fact what they need is a good product and a few algorithms requiring high-school level maths. I think this pretty much solves 90% of the problems in the software business.
366.
by searine 9y ago
Not surprising. Social networks grow when they are cool, and Facebook is about the farthest thing from cool right now. It got taken over by old people and companies looking to convert you to brands/religion/politics, all of which
367.
by searine 9y ago
No citation, just personal experience aligning the data and comparing it directly to a hiSeq run of the same DNA. I was able to get about 1-10% mutation rate, with a median of about 1.5%. Rate depending on quality of the run. In general it
368.
by searine 9y ago
> Getting anywhere near the quality of the Human Genome Project is not possible. That is an unrealistic and inappropriate metric to use. The HiSeq X isn't mean for making new human reference genomes. It's meant for re-sequencin
369.
by searine 9y ago
Yes, if you were willing to shell out 1000 bucks for the test, and if the bacteria was in your bloodstream (unlikely). If you swabbed, cultured, and sequenced, it'd be a better test. I've personally used the oxford nanopore to dia
370.
by searine 9y ago
>The error rate is stupidly high (somewhere between 10 and 20%) The Insertion/deletion error rate is 20-30%. The point mutation error rate is something 0.1-1% (higher than HiSeq but not crazy high). This means with a semi-decent ref
371.
by searine 9y ago
What does any of that have to do with not using bigotted language?
372.
by searine 9y ago
>Bigotry isn't really about words Words matter. Bigotry isn't just words, but words matter. A lot. Instead of dumping a ton of words defending bigotry, maybe just use a few well chosen ones to denounce it.
373.
by searine 9y ago
>Are you making an "intent is irrelevant" argument about speech outside the workplace? I am accounting for the fact that people of different backgrounds interpret statements differently. >What if the speaker cares about expr
374.
by searine 9y ago
>When a feminist says "kill all men", they're saying "the patriarchy has oppressed women for centuries and I'm angry about it". That might be your intent, but that is not how it is interpreted. It sounds big
375.
by searine 9y ago
This is a fun parallel, but I feel like it fails to go the other direction. How is DNA different from programming? This is important to understand because those differences are the foundation of our intuition about how DNA operates. We can&
376.
by searine 9y ago
I learned a long time ago that the solution to a problem is never a blanket ban on a product or tech. All that does is punish well-intentioned or needy people. Trade fees are a relic, and deserve to die. They do nothing but skim money from
377.
by searine 9y ago
I love science history. Probably my favorite non-fiction topic to read.
378.
by searine 9y ago
Who makes money in a gold rush? It's the guy selling shovels.
379.
by searine 9y ago
Link to actual data instead of clickbait : https://wellbeing.smgov.net/about/wellbeing-index
380.
by searine 9y ago
It's also the fact that the author's family is heavily admixed. That makes assigning them to any one group precisely, a very difficult task with large margins of error.
381.
by searine 9y ago
I disagree. Mostly for one reason alone. Genetic association testing. To get statistical power necessary to associate variants with complex genetic traits, we need very large sample sizes (hundreds of thousands are good, millions of individ
382.
by searine 9y ago
My local Burger King has transitioned to this. I don't often eat there, but I'll admit it is a guilty pleasure. One interesting thing I've noticed is that with ordering kiosks, I'm much more likely to be upsold. Having a
383.
by searine 9y ago
Blockchain might be useful here, sure. Is that use worth 44% of their stock? Doubtful.
384.
by searine 9y ago
Short kodak.
385.
by searine 9y ago
Rising complexity of financial instruments? Check. Uncertainty about the capital backing of a booming market? Check. FOMO fever? Check. Where have I seen this before?
386.
by searine 9y ago
>Thanks to Coinbase’s efforts, more than 480,000 customers’ records were preserved from disclosure. If you think they're giving up, you got another thing coming. Reliable exchanges mean eventual taxation.
387.
by searine 9y ago
Maybe don't steal from your neighbor by dodging taxes?
388.
by searine 9y ago
This was inevitable and a good thing. Crypto has been extremely risky because there is no sure-fire exit strategy. Now that reliable exchanges like coinbase are popping up, and playing by the rules, that risk is going down drastically. A re
389.
by searine 9y ago
Capital gains are capital gains. It doesn't matter how you made it.
390.
by searine 9y ago
Because the electricity, roads, laws and communications which support your monopoly money currency need to be funded. If you want to go make a million dollars, more power to you, but you also need to pay your fair share like everyone else.

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