searine

4 ms·

1.
by searine 18d ago
I saw a really interesting talk by Katie Pollard at ISMB this year about the limitations of variant prediction. The gist was, can existing variation provide enough context to infer impact of variation? The answer seemed to be no. Kind of li
2.
by searine 1mo ago
I might decide to shit on your front porch every morning. It is the definition of a personal decision.
3.
by searine 1mo ago
It's about protecting each other, basic empathy. Doing the bare minimum to and taking miniscule risk to protect the lives of people around you. Sorry that's hard to understand.
4.
by searine 1mo ago
Because, it is always all about you...
5.
by searine 2mo ago
Computation is not the hard part of discovery.
6.
by searine 3mo ago
Its not just what makes the news. There is a cooling effect happening in recruiting international talent. Science is heavily international, and if people feel like they won't get funding/wont be safe here, they won't come.
7.
by searine 3mo ago
As an 'at home' science project? Totally do-able, but very expensive. I did it as part of epidemiological field with a backpack of materials, so you can definitly do it at home. As a useful genome? Marginal. ONT will need a couple
8.
by searine 3mo ago
>The government is going to suck at funding the right things. The government is actually really really good at funding the right things. The grant process has been extremely successful in directing funding efficiently towards cutting edg
9.
by searine 4mo ago
Simple, excellent data. Thanks.
10.
by searine 5mo ago
Is it excessive? Expensive, certainly, but if I wanted cheap I'd go live in shack in the mountains.
11.
by searine 5mo ago
Thats not true at all. If anything, they will read the figures and skip the introduction. If it is your field, you don't need an intro, and don't want to hear whatever yarn they are spinning in the abstract/discussion. You ju
12.
by searine 7mo ago
Agreed. Seeing million dollar sequencers on ebay for a few thousand bucks makes me want to reach for my wallet, but the I realize there are no reagents for it anyway.
13.
by searine 8mo ago
Short of plopping a million dollars on the table, you could not.
14.
by searine 9mo ago
This entire demo is just a surveillance state dog-whistle. "It's used for car theft!" except the intended use is obviously target government buyers for tracking citizens.
15.
by searine 9mo ago
Which led to the discovery of a marijuana grow operation below the factory. https://www.nytimes.com/2015/02/27/nyregion/secret-marijuana...
16.
by searine 10mo ago
I do not want some working on my body unlicensed and educated by chatgpt.
17.
by searine 11mo ago
Technically neat, artistically uncanny. There's been vector based tweening and animation software for a bit an it always comes out looking strange.
18.
by searine 11mo ago
Prevention is cheaper than treatment.
19.
by searine 11mo ago
There has been a lot of talk the last several years about the risks of screening, but in my opinion people have taken this as an opportunity to swing in the opposite extreme. The message shouldn't be "get screened" in the sam
20.
by searine 11mo ago
Hyperbole. I am not going to avoid any reasonable treatment/screen because of it. It was intended to catch asymptomatic cancer. Additional invasive screenings are voluntary and like all treatments they carry risk. I weigh all treatment
21.
by searine 11mo ago
I did this recently. Paid out of pocket, but it was worth it for the peace of mind. It's not perfect but it's easy/fast and a good way to screen for big problems.
22.
by searine 11mo ago
This research was primarily done at John's Hopkins in Baltimore and funded by NIH's National Institute of Neurological Disorders and Stroke.
23.
by searine 1y ago
> My claim is that there is a gap between how science is done and how it is presented to the public. There is a gap between how software is written and how it is used by the public. Clearly computers are flawed and need a complete rework
24.
by searine 1y ago
I think our impasse is for some reason you have this idea that PI's hate their work / are gaming the system. I just don't understand where you are coming from. Maybe that's true sometimes, but most all PIs I have worked
25.
by searine 1y ago
>Difficulty is not value. Extremely talented people are doing arbitrary waste work. Grants are hard, not because of admin/paperwork, but because coming up with a novel idea is hard and convincing others to fund it is harder. The peo
26.
by searine 1y ago
You have no idea what you are talking about, and yes you are buying into (or actively promoting) anti-intellectualism. >1. Our top researchers are wasting their time and energy promoting projects for grants. There are all kinds of scient
27.
by searine 1y ago
Having an excess PhD level citizens is every free countries wet dream. Its bonkers that people think it is somehow a negative. It is a recipe for innovation. Most of those people want to do things with their knowledge, not teach classes. Mo
28.
by searine 1y ago
This is anti-intellectual propaganda. Seriously, 90%? None of what you said is happening at anywhere near that scale. Touch grass.
29.
by searine 1y ago
That success rate tracks with most common types of surgery, there are always edge cases. The exception is back surgery, and the odds get worse and worse if revisions are necessary.
30.
by searine 1y ago
Academia is already a sandbox. What kind of research would fit poorly? In the article most of the examples of funding sources give their funding to academic labs already. Discussion about non-governmental sources of funding is fine, but the

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