> Getting anywhere near the quality of the Human Genome Project is not possible. That is an unrealistic and inappropriate metric to use. The HiSeq X isn't mea

> Getting anywhere near the quality of the Human Genome Project is not possible. That is an unrealistic and inappropriate metric to use. The HiSeq X isn't mean for making new human reference genomes. It's meant for re-sequencing at scale, and speaking from personal experience, it does an incredible job in quality, speed, and cost. Even if we could reach reference assembly quality with a hiseq run, we wouldn't want to use it that way. Having reference genomes and annotations (hg19 and hg38) means we can compare and contrast individuals from a common foundation. It would increase the cost and time of genome analysis 100 fold if we had to do denovo assemble for each individual sequenced.