rsfern

30 ms·

391.
by rsfern 5y ago
COVID-19 isn’t the same as a positive SARS-CoV—2 test. This is what they measured, from the caption of table 10 in the pfizer fact sheet you linked: > Note: Confirmed cases were determined by Reverse Transcription-Polymerase Chain Reacti
392.
by rsfern 5y ago
Why are you continuing to misrepresent the EUA documents? They don’t support your assertion. (If you point to where in the authorization docs they specify the goal is to prevent SARS-CoV-2 infection, I’ll change my mind. I linked the modern
393.
by rsfern 5y ago
The moderna application clearly distinguishes between Covid-19 (symptomatic disease) and SARS-CoV-2 infection, as the sibling comment says. > On November 30, 2020, ModernaTX (the Sponsor, also referred to as Moderna) submitted an Emergen
394.
by rsfern 5y ago
That’s not correct, the clinical trials explicitly measured symptomatic disease and not transmission e.g. https://clinicaltrials.gov/ct2/show/NCT04470427
395.
by rsfern 5y ago
No, but thinking about it that would make sense. Is that considered the correct posture? I’ve always used my pinky finger for L and ?
396.
by rsfern 5y ago
That’s interesting. I guess I never really thought about it, but on dvorak `ls` is a double tap with the right pinky, and it’s often immediately followed by [enter] with the same pinky… I type that key sequence a lot
397.
by rsfern 5y ago
The US has multiple such systems that serve different purposes. We have a passive monitoring system (VAERS) that you might be referring to in data quality issue. It’s for identifying side effects for further study, and it’s explicitly but f
398.
by rsfern 5y ago
The link isn’t dead for me, but I guess there’s no abstract on pubmed, sorry. This is the DOI link: https://DOI.org/10.1001/jama.2021.14808 It’s an editorial summarizing the first VSD report on Covid vaccine side effec
399.
by rsfern 5y ago
They were all doubly blinded placebo controlled trials… Are you talking about how they unblinded the study after efficacy results started coming in?
400.
by rsfern 5y ago
You shouldn’t distrust VAERS per se, but it’s purpose is not risk assessment. It’s purpose is surfacing rare side effects for further study. You don’t have to trust the drug co’s for that, we also have vaccine safety datalink system; so far
401.
by rsfern 5y ago
VAERS is for surfacing hypotheses about rare side effects For serious risk quantification and causal analysis, we have things like the vaccine safety datalink, which links all electronic health records across a bunch of hospital systems, co
402.
by rsfern 5y ago
I don’t think they are allowed to ask those questions. They certainly aren’t allowed to discriminate in hiring or employment based on disabilities https://www.eeoc.gov/laws/guidance/your-employment-rights-in...
403.
by rsfern 5y ago
Since this seems to be generating some controversy (presumably because Big Pharma?) what alternative research and drug discovery, development, testing, and manufacturing ecosystem should we as a society strive for? There are some interestin
404.
by rsfern 5y ago
Do you have a source on Belgium? I found this article from a week ago that says that a single hospital (as far as I can tell) had no omicron icu patients at time of publication, but it also indicates that they might not be tracking it that
405.
by rsfern 5y ago
Usually they used randomized controlled trials for this sort of thing, which in a well designed study will account for this sort of bias Whether the population in the trial generalized to the population at large is a bit different question
406.
by rsfern 5y ago
Interesting, thanks! I guess most of the reputation of cast iron comes from the chunky shapes of the pans, and that the higher end stainless cookware is often cladding around copper core
407.
by rsfern 5y ago
Ivermectin and hydroxychloroquine were met with cautious optimism by the research community after the first preliminary hits in screening experiments for drug repurposing, exactly as you’re advocating [0]. The tides turned when things didn’
408.
by rsfern 5y ago
Do you have a substantive critique about the actual article? I found it pretty reasonable and detailed, and consistent with what I’ve been reading elsewhere. And there’s even a dedicated section pushing back on the doom and gloom attitude A
409.
by rsfern 5y ago
For context, this journal uses crowd sourced open peer review, which is an interesting concept. There’s one review, and it’s (IMO) not substantive. I would treat this as a preprint basically (not that you shouldn’t read peer reviewed studie
410.
by rsfern 5y ago
They’re not quite the same, cast iron generally has a higher carbon composition range and a different phase distribution. Cast iron has a much lower thermal conductivity
411.
by rsfern 5y ago
> I have an induction cooktop and my cast iron pans have been terrible. Cast iron has lousy heat conduction and induction stoves do not have even distribution. That’s interesting, can you compare the heat distribution problem to resistiv
412.
by rsfern 5y ago
Sure, but you can search for local optima, and then there’s all the environment specific factors, solvation, finite temperature, that sort of thing. Really you want the local energy landscape so you can understand dynamics and stability. (I
413.
by rsfern 5y ago
You’re describing reproducibility in checking a hypothesis about statistical association. There doesn’t need to be any theory involved to generate that hypothesis. Often there is, but often in modern drug discovery pipeline the lead generat
414.
by rsfern 5y ago
The protein structure prediction example (AlphaFold) is interesting, because the problem they’re addressing is not that we have no theory per se, but solving the geometry optimization problem directly with ab initio quantum mechanical calcu
415.
by rsfern 5y ago
I guess so? The bit I quoted was about the extent of the relevant discussion. The rest was on how one year is a more reasonable spacing for boosters, if we need them, and how so many people getting omicron probably will reduce the likelihoo
416.
by rsfern 5y ago
This is about fourth doses (and beyond), not third dose boosters. > On Tuesday, EMA vaccine strategy chief Marco Cavaleri said there was still no data supporting the need for a fourth COVID vaccine dose. Also the actual title of the arti
417.
by rsfern 5y ago
I think they’re just pointing out that there could be unintended consequences to just simply barring Congress members from trading - maybe it just increases incentives for back room deals and the like? Transparency in this case is a much hi
418.
by rsfern 5y ago
The nature medicine paper is still online, so I’m not sure about the memory hole hypothesis https://www.nature.com/articles/nm.3985
419.
by rsfern 5y ago
> It will allow a bunch of people to skim-read detailed research publications and miss all the nuances that matter. I have to disagree, there’s nothing stopping readers from doing this already, I think it’s quite common I do agree that
420.
by rsfern 5y ago
One thing to note - they cover case reports following six major vaccine platforms, not just the mRNA ones. The review seems pretty good about differentiating when summarizing, but a lot (maybe a third?) of their descriptions of the individu

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