Pyramus

22 ms·

361.
by Pyramus 5y ago
I think the point parent is making is slightly different. Let me try to re-phrase it negatively: What we don't know about mRNA vaccines we don't know about SARS-CoV-2 either. Our state of knowledge of the effects of SARS-Cov-2 wil
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by Pyramus 5y ago
> almost nothing bad will happen If we pick the 25-29 year olds and an estimated infection fatality rate of 0.01% [1] it's still 13.5M x 0.01% = 1,350 deaths. It's not a lot by any means, but it's not 'almost nothing&
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by Pyramus 5y ago
Not far higher, the population-based average is roughly 99.0%, but varies depending on gender and age [1]. [1] https://www.nature.com/articles/s41586-020-2918-0/figures/2
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by Pyramus 5y ago
They aren't - at least one out of nine patients with blood clots from AZ vaccine was male [1]. [1] https://www.researchsquare.com/article/rs-362354/v1
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by Pyramus 5y ago
Parent specifically stated DNA viruses. From your article: > Most of these viral genes come from retroviruses, RNA viruses that insert DNA copies of their own genes into our genomes when they infect cells. HHV-6 is unique because it is t
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by Pyramus 5y ago
To add, from the German Federal Institute for Vaccines (regarding AZ not J&J): > Birth control pills can also cause thrombosis. So why is there all the fuss about the COVID-19 Vaccine AstraZeneca? > It is true that for birth contr
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by Pyramus 5y ago
Follow-up question: Do these effects (which are very unlikely) differ between vaccine and the virus itself? Or maybe: Is the epigenetic risk higher/different?
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by Pyramus 5y ago
It seems to me you are picking one outcome, all-cause mortality (link to the study in question with nice dose-response curves [1]) but ignoring cardiovascular disease, type 2 diabetes, brain health, cognitive function, falls, accidents and
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by Pyramus 5y ago
I don't understand. The study you cited, a meta-analysis, reviews the adverse effects of short and long sleep on * Mortality * Incident cardiovascular disease * Incident type 2 diabetes * Mental health (incident depression) * Brain hea
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by Pyramus 5y ago
This is one of my favourite topics that seems straightforward (What's the optimal sleep length?) but is a lot more tricky. > If you go through actual studies and systematic reviews it is really hard to make much of a case that 6 hou
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by Pyramus 5y ago
I agree with your assessment that 'more of something bad' is not necessarily better. In addition it should be noted that the study relies on actigraphy, yet the shortcomings of actigraphy are waved away. This doesn't mean we
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by Pyramus 5y ago
This estimate is quite robust, e.g. researchers observed how long different hunter-gatherer societies sleep etc. In addition it should be note that it's distributed like a Gaussian distribution, so there will be plenty of people outsid
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by Pyramus 5y ago
Per design the scientific method can only make claims about large samples or 'averages'. If we assume a claim is normally distributed there will always be folks in the left and right tails which are not average - in fact 32% will
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by Pyramus 5y ago
I'm not sure I understand. The absolute number of positive test cases is a best guess, a temperature gauge, no absolute truth. The true number of cases is unknown and estimated to be 1.5-3 times the number of positive cases (from sero-
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by Pyramus 5y ago
"It will impact country X but not us" has been a consistent pattern in this pandemic, and it does not make me optimistic going forward. I'd argue that the countries that did face SARS have handled SARS-Cov-2 better than the o
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by Pyramus 5y ago
Apologies, I've misread your comment as 'experts didn't consider X', which to my surprise was a common pattern in the responses. You do clearly criticise the news coverage, not the experts. I agree with you that loosing
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by Pyramus 5y ago
Yes, this was one of the surprises early on that Covid risk matches background risk relatively closely [1]. Which is not a good thing, especially on a societal level, when you have this one thing killing people at the rate of all other thin
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by Pyramus 5y ago
Let's do a worst case calculation and assume you are a women aged 30. The infection fatality rate of Covid for this age and gender is 0.01 % or 1 in 10k (based on seroprevalence data not test data [1]). The fatality rate for the AZ v
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by Pyramus 5y ago
No, it was always above the background level (at least in several EU member states) and this has not changed. See e.g. German data from 3 weeks ago: > The number of these cases after vaccination with COVID-19 AstraZeneca is statistically
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by Pyramus 5y ago
You are significantly underestimating the experts working on evaluating these cases: > The number of these cases after vaccination with COVID-19 AstraZeneca is statistically significantly higher than the number of cerebral venous thrombo
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by Pyramus 5y ago
For what it's worth I've read that under today's circumstances birth control would not have received marketing approval. See also: > Birth control pills can also cause thrombosis. So why is there all the fuss about the COV
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by Pyramus 5y ago
It's not misleading at all, there is no doubt that there is a direct link between the AZ vaccine and these rare thrombosis cases. This link has been evidenced in several member states of the EU (see e.g. my sibling comment [1]) roughly
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by Pyramus 5y ago
The Paul Ehrlich Institute (German Federal Institute for Vaccines) has an excellent FAQ on the topic [1]. Here is the direct link to the statement from the German Society for Thrombosis Research that pioneers the idea of heparin-induced thr
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by Pyramus 5y ago
> 1. Basically anything that's expensive has had its price inflated in some way. That doesn't make it anyone any less willing to pay the price. That doesn't make sense. Liquid expensive things like gold have a market price
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by Pyramus 5y ago
Another alternative is to simply buy second hand or from an auction. Personally I see diamonds in a league with works of art. There is definitely value, but it's subjective, generally a lot less then expected and highly illiquid.
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by Pyramus 5y ago
In the above paragraph replace "the media" with "doctors", "scientists", "politicians", "elected officials", "the police", "big pharma", "journalists" ... I&#x2
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by Pyramus 5y ago
Nothing really - printing the name of a murderer, say, is a trade-off between the public's right to know and the person's right to privacy. Simply speaking: Also assumed murderers, say, are humans and have rights. Different countr
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by Pyramus 5y ago
What/who is "the media"? I see this pattern where you define a class so broad any proposition becomes a truism, and productive discussion becomes impossible.
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by Pyramus 5y ago
I don't have an answer for long-term melatonin unfortunately. In most folks circadian rhythm is not exactly 24 but slightly more or less. In this case it is helpful to force the sync by getting exposure to sun light (or a source of sim
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by Pyramus 6y ago
I do not live in the US, so YMMV, but I can only re-iterate that this has absolutely not been my experience. Have you actually spoken to somebody 'in power'? Go to the next council meeting, speak to your local mayor, call a local

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