5 ms·
Online clinics and influencers are promoting Cialis as a longevity drug
- woliveirajr 2mo agoSildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest. Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor. Help to live longer was the main objective since the beginning. [0] https://en.wikipedia.org/wiki/Sildenafil#History https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History https://en.wikipedia.org/wiki/Tadalafil#History
- joezydeco 2mo agoI invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation. And all we got was another boner pill.
- fny 2mo agoLifespans and inflammation are ironically harder problems.
- fragmede 2mo agoDuring your extended lifetime, wouldn't you like to be able to have a boner, though?
- NordStreamYacht 2mo agoPicasso managed it all without these meds.
- fragmede 2mo agoIf you're saying it's easy, just be as good as Picasso, imma be real with you and say I'm not as good as Picasso.
- graceful6800 2mo ago....in bed
- giantg2 2mo agoQuanity and/or quality of sex shows correlation with longer lifespan. Maybe this is a roundabout way to get there...
- VyseofArcadia 2mo agoWell they extended something at least.
- m463 2mo agosome lifespans are shorter when insemination never occurs.
- jacknews 2mo agoMaybe the extra sex is the main benefit?
- brandonb 2mo agoCan't rule out exercise.
- Geof25 2mo agoMonkey paw wish - you will live longer, but you will be constantly erect.
- MarkusQ 2mo ago[flagged]
- busterarm 2mo ago[flagged]
- thinkthatover 2mo agosimilar monkey paw in TW3 sidequest: https://witcher.fandom.com/wiki/Goodness,_Gracious,_Great_Balls_of_Granite https://witcher.fandom.com/wiki/Goodness,_Gracious,_Great_Ba...!
- stronglikedan 2mo agoI used to hear that sexually active couples lived longer, so there's that.
- comrade1234 2mo agoThe weirdest thing I read about was weightlifters taking viagra to increase their blood flow when working out at the gym. Hopefully they shower at home.
- GenerWork 2mo ago>weightlifters taking viagra to increase their blood flow when working out at the gym The weightlifting community moved off of Viagra years ago due to Cialis having a much longer half life.
- throwawaytea 2mo agoJust an FYI, these drugs don't actually cause erections or sexual excitement. They simply make erections easier. Now, if someon is mildly excited by other bodybuilders but usually not enough to make it known, yes Cialis could cause 'movement' as George Costanza put it. But if you're not into what's in front of you, Cialis isn't going to change anything.
- KellyCriterion 2mo ago...then please throw a 20mg Taladafil and go to the Gym - good luck! :-D LOL
- KellyCriterion 2mo agoFor all the downvoters: While Taladafil does not have a psychotropic effet (like Extacy, MDMA etc.), just the friction of your sport clothes may be a problem for your "experience", and visiting the sauna afterwards will be very likely somehow problematic if sauna guests match your preferences, to put it in a diplomatic way ;-)
- bushwart 2mo agoYou shouldn't be creepily ogling the gym baddies anyway no matter what you're on. Tadalafil is perfectly fine in the gym or the sauna as long as you control where your attention goes.
- francisofascii 2mo agoSuprised this article doesn't mention nitric oxide or vasodilation? Is that how it works. It boosts nitric oxide signaling, acts as a vasodilator, and improves endothelial function. Beet juice, exercise, and eating nitrate-rich vegetables are some non-pharmaceutical ways to have a similar effect.
- josh-wrale 2mo agoI thought nitrates were dangerous with regard to cancer. (?)
- mikestew 2mo agoNot quite the same thing despite sounding very similar: https://www.mdanderson.org/cancerwise/what-to-know-about-foods-with-nitrates-and-nitrites.h00-159694389.html https://www.mdanderson.org/cancerwise/what-to-know-about-foo... (And good gracious, HN, how about answering the person’s question instead of downvoting it?)
- josh-wrale 2mo agoThanks.
- vonneumannstan 2mo agoNot sure what the parent comment is referring to exactly or if they are also conflating things but: Nitric Oxide = NO is not the same as common carcinogens in foods like Sodium Nitrite = NaNO2 or Potassium Nitrate = KNO3
- josh-wrale 2mo agoThanks.
- Noaidi 2mo agoBoth of these nitrates turn into NO in the body. https://pharmrev.aspetjournals.org/cms/10.1124/pr.120.019240/asset/4551ed88-8c53-446a-a2ab-26b1c31b8921/main.assets/gr5_lrg.jpg https://pharmrev.aspetjournals.org/cms/10.1124/pr.120.019240... While it is a cancer risk this is not true for all peoples.
- jurip 2mo agoThere was also just last week this study, which indicated a link to a higher risk of glaucoma: https://www.thepharmacist.co.uk/clinical/mens-health-clinical/erectile-dysfunction-drug-may-increase-risk-of-glaucoma/ https://www.thepharmacist.co.uk/clinical/mens-health-clinica...
- khalic 2mo agoAs usual, without double blind studies, this is playing with fire… maybe the people taking it have better health because of the extra exercise that goes with an active sex life.
- dpark 2mo agoI would imagine the sex itself isn’t super relevant in terms of exercise. But people who seek out medical treatment (or enhancement) likely take better care of themselves in general. But I would be surprised if there were not a measurable increase in health markers for men who take Cialis. Pretty much any drug that reduces blood pressure is going to have a positive effect on longevity for the average male population (but not the sub-population who have low blood pressure).
- astura 2mo ago>people who seek out medical treatment (or enhancement) likely take better care of themselves in general. That was immediately my thought as well, the population of men who seek out ED medications have to be very distinctly different than the population of men in general.
- LorenPechtel 2mo agoSex probably isn't that relevant--but being able to have sex says something about your health. Thus this very well might be a yardstick, not an actual benefit.
- Modified3019 2mo agoFYI, before reaching for PDE5 inhibitors, please be aware that these seem to be ototoxic in some way. Common side effects are tinnitus and to a lesser extent hearing loss. When taking these, you should track if there are changes to your hearing and cease immediately if you notice something. The damage seems cumulative and based on dose, and may resolve quickly, over months, or not at all. You should also look into any other medicines you take to see if they are ototoxic.
- raspasov 2mo agoStudy link and/or source?
- Good4boothee 2mo agohttps://en.wikipedia.org/wiki/Ototoxic_medication#Other_examples_of_ototoxic_medications https://en.wikipedia.org/wiki/Ototoxic_medication#Other_exam... has some sources. Worth noting NSAIDs like aspirin are also listed there.
- dpark 2mo agoThat’s a helpful reference. If accurate, the method of action here is simply nasal congestion (a common side effect).
- Noaidi 2mo agoFascinating! I have non-hearing damage induced Tinnitus and Bipolar Disorder and have been interesting in my PDE genetics for sometime as a link to my issues. It seems I have a natural inhibition of many PDE genes (PDE4B specifically, but I have some less studied changes in my PDE5A genetics which suggests an inhibition there as well). Sildenafil has been know to make BP people relapse in one case... https://academic.oup.com/ijnp/article/7/4/525/707950?login=false https://academic.oup.com/ijnp/article/7/4/525/707950?login=f... And also investigated with some mood issues... https://link.springer.com/article/10.1007/s00213-023-06361-3 https://link.springer.com/article/10.1007/s00213-023-06361-3 Zinc and Magnesium are cofactors for all the PDE genes and those have helped me, specifically the zinc. I have a feeling that low GTP is causing issues in ED since Cyclic GMP is made from GTP.
- schrectacular 2mo agoMaybe not longer, but definitely harder.
- miiiiiike 2mo agoCheck your blood pressure regularly. Every time I read about a drug reducing dementia risk or increasing longevity I look it up to see if it lowers blood pressure. Never fails. Cialis does.
- toasty228 2mo ago> Check your blood pressure regularly. Also avoid things that increase blood pressure and do more thing that improve your cardiovascular system. No amount of drug will make up for decades of abuse
- larodi 2mo agosuch as alcochol of course
- exhilaration 2mo agoVery interesting. Since you've spent some time thinking about it, what's your hypothesis of the connection between high blood pressure and dementia? Any interesting links you could share? Maybe high blood pressure causing more pressure in the blood vessels of the brain, leading to a lifetime or decades of cumulative damage?
- Qem 2mo agoMicrostrokes, that affect capillary vessels in the brain, don't cause short term acute loss of function, but have a cummulative impact over time?
- m463 2mo agoI wonder if flomax (tamsulosin) figures into all this because lowered blood pressure can be a side effect.
- karakoram 2mo agoCorrect me if I am wrong but I think marathon runners take Cialis for something too.
- mikestew 2mo agoSerious lifelong runner here, and it’s news to me. OTOH, it may be an influencer bro-science thing that I’ve successfully ignored. OTOOH, I take beet juice powder, which is to increase blood flow pre-run, so I would not be surprised if folks “leveled up” to a pharmaceutical.
- stronglikedan 2mo agoI hope so, since I take it daily for my enlarged prostate.
- hulitu 2mo agoWhat's wrong with Viagra ?