6 ms·

Taming the Flame of Aging: Key Pathway for Chronic Inflammation Revealed

90 points by gardenfelder 3y ago

gardenfelder 3y ago
>Researchers have unveiled the key role of the cGAS/STING molecular signaling pathway in driving chronic inflammation and functional decline during aging. The team discovered that blocking the STING protein suppressed inflammatory responses in aging cells and tissues, leading to improved function.
gessha 3y ago
In mice
- everybodyknows 3y ago
  > Using explants of human adipose tissue from individuals with obesity, in whom the adipose tissue accumulates senescent preadipocytes12, we confirmed that STING inhibition by H-151 suppressed the release of proinflammatory signals from senescent cells at the tissue level (Extended Data Fig. 3).
freilanzer 3y ago
First immortal mice when?
- IIsi50MHz 3y ago
  When no cats. (-: …okay, maybe a few other requirements.
rybosworld 3y ago
Is the key problem here that the inflammation is chronic? My understanding was that inflammation is a very necessary part of the healing process. I would have thought that blocking the inflammation process would be catastrophic for healing.
- woleium 3y ago
  I'd imagine there are times when it would be useful. I had assumed that inflammation was more to do with fighting infection than healing, but I may be wrong.
  - maksimur 3y ago
    Doesn't inflammation happen when building muscle? Isn't muscle building a healing process?
  - nradov 3y ago
    Inflammation plays a role in stabilizing damaged tissue and accelerating the healing process. This is one reason why the common practice of using ice to treat musculoskeletal injuries probably does more harm than good in most cases. https://www.outsideonline.com/health/training-performance/good-to-go-book-christie-aschwanden-questions-recovery/ https://www.outsideonline.com/health/training-performance/go...
- kypro 3y ago
  Yes, you're correct. You can inhibit inflammation, and some people do, but you'll almost certainly be increasing your risk for cancer and other diseases. The goal should be to decrease chronic baseline inflammation while maintaining a healthy inflammatory response.
- michaelhoney 3y ago
  Correct: chronic inflammation is bad, but acute (and often, localised) inflammation is part of the body’s healing mechanism.
jacknews 3y ago
So is there anything left for Mid-2023? We got AGI, pretty much, (it's artificial, it's general, and fairly intelligent by most standards), and in last few weeks, we might have room temperature superconductors, a cure for cancer, and now a cure for aging? Can't help but wonder if there's a connection, lol.
- Brajeshwar 3y ago
  They finally start using the tech buried millions of years ago by Who-Who-Must-Not-Be-Mentioned.
  - jacknews 3y ago
    Right, I forgot all about the secret UFO recovery program now allegedly coming to light. Maybe it's all from there, lol.
- wuming2 3y ago
  Perhaps the first generated the next one and so on. Let’s wait for hallucinations now.
  - jtbayly 3y ago
    Perhaps the rest of the mentioned amazing advancements are the hallucinations...
- fallingknife 3y ago
  Don't forget the totally unrelated UFO hearings in congress...
- Phenomenit 3y ago
  What are you referring to when you say cure for cancer?
  - htp 3y ago
    I assume this is a reference to e.g. https://news.ycombinator.com/item?id=36982813 https://news.ycombinator.com/item?id=36982813
everybodyknows 3y ago
To spare you the animated ads, direct link: https://www.nature.com/articles/s41586-023-06373-1 https://www.nature.com/articles/s41586-023-06373-1
swamp40 3y ago
> More importantly, animals receiving STING inhibitors displayed significant enhancements in spatial and associative memory. I don't suppose there is some herbal STING inhibitor already available OTC?
- tmikaeld 3y ago
  There isn't, finding inhibitors (natural or synthetic) that can specifically target STING without disrupting other essential cellular processes is a challenge. However.. Resveratrol, a natural compound found in grapes and red wine, has been studied for its potential to modulate STING activity, though not the STING protein specifically (from what i can find). There's also speculation that the gut microbiota plays a role in modulating the immune system and it's possible that certain bacteria could influence STING activity.
roody15 3y ago
Just my take as a middle aged human watching myself and others age I see a connection with alcohol / inflammation and aging. From my experience: people who drink frequently age much worse and this could be related to inflammation. Alcohol is obvious poison but even drinking a beer here or there causes inflammation … let’s say you drink one beer a night after work … I think this exacerbates the aging process by leaving the body in constant inflamed state. This is based on nothing other than my own anecdotal observations
- darkclouds 3y ago
  So the next question is, what makes alcohol attractive in the first place and what does it deplete? Maybe the depletions are a clue? I've only got so many stem cells, so whilst it might seem logical to reduce inflammation to preserve the demand for stem cells, how can I increase my red bone marrow? Filgrastim is not an answer. Answers on a Postcard to:-
  - gottorf 3y ago
    Puzzlah Towah, Hahvahd Squah
  - roody15 3y ago
    What makes alcohol attractive. In my experience alcohol in many social situations helps people form a connection (cutting through layers of bs we masquerade around with). It helps people break the ice and form a bond .. both as just friends and also with possible love interests. The issue that I have seen is that we humans form habits (and addictions). So let’s say alcohol helped me make some friends in college and hook up with a lady friend who become a serious romantic long term partner. Your brain is like yeah .. she alcohol helps… and the inflammation issues take years before you notice any symptoms. Years later you just now associate alcohol with socializing and good time .. or even associate with relaxation. As you age and life is stressful this can dangerous because now your body has become dependent on this substance for mental relaxation / stress unwinding. Now you find yourself drinking by at home with no love interest and maybe just alone without friends. Fast forward now you find yourself overweight and having health issues … and your like man cannot believe this is happening to me .. aging sucks and I am unlucky. Your subconscious and habit do a good job of stopping you from making any connection that perhaps alcohol has been playing a role here. Side note: I am friends with a couple recovered alcoholics and am just basing my rambling response based on my own life experiences.
dsign 3y ago
Let's assume this is confirmed and that tomorrow an inhibitor that also works is found. How many decades from now until one can go to the doctor and get the inhibitor prescribed? Any bets?
- deleted 3y ago
  [deleted]
dazzaji 3y ago
I barely understand the actual research so I tried getting Claude 2 100k to walk me through it. It stresses that the findings are primarily important for guiding future research. Interestingly, when I then asked if there are any actions I could take today to avail myself of the findings I got what appears to be some reasonably well aligned suggestions. However, I’m way out of my depth here. Does anybody know if the following (or any part of the following) is sound or for that matter if it’s terrible? Here’s what I got: “ Here are some potential ways you could apply the findings from this study in your daily life: Diet: - Eat foods rich in antioxidants and anti-inflammatory compounds like curcumin (turmeric), catechins (green tea), and anthocyanins (berries) that may help reduce inflammation. - Consume foods rich in NAD+ precursors like nicotinamide riboside or tryptophan to potentially support mitochondrial function. - Follow an intermittent fasting regimen, which may enhance mitochondrial health and reduce inflammation. - Limit foods high in saturated fats, added sugars, and processed carbs that can promote inflammation. Supplements: - Take supplements that may inhibit cGAS/STING like quercetin, curcumin, green tea extract. However, speak to your doctor first. - Consider supplements to support mitochondria like CoQ10, nicotinamide riboside, and alpha-lipoic acid. Lifestyle: - Exercise regularly as it can reduce inflammation, improve mitochondrial function, and stimulate brain plasticity. - Practice stress reduction techniques like yoga and meditation which may decrease inflammatory genes. - Get sufficient sleep since sleep deprivation can increase inflammatory cytokines. - Challenge your brain with cognitively stimulating activities to potentially promote neuroplasticity. - Quit smoking, as it increases inflammation and oxidative stress. However, changes should be made cautiously and discussed with a health professional. While the study provides promising areas to target, more research is still needed to confirm effects in humans.”
- hkatx 3y ago
  NAD+ is available in a supplement form very popular in longevity community. IF/intermittent fasting induces autophagy. Also popular in longevity/health folks. Our diets are so poor, I wonder if the benefit comes from eating less or by sticking to a feeding window. But the evidence is for it. It can't hurt you as long as you meet your nutritional requirement during your feeding window. >Limit foods high in saturated fats, added sugars, and processed carbs that can promote inflammation. Most metabolic diseases first line of treatment is diet modification. >cGAS/STING like quercetin, curcumin, green tea extract. However, speak to your doctor first. Do talk to you doctor. Quercetin metabolism does interfere with hormone (I know in men) But it is inflammatory. Green tea extract could hurt kidney so be careful with the source. >CoQ10, nicotinamide riboside, and alpha-lipoic acid CoQ10 is a co-enzyme recommended for heart patients. In healthy adults it can't hurt. Alpha lipoic acid is an essential fatty acid. Salmon/tuna is rich in it or also available in supplement. Do take a quality source because most fatty acid supplement is rancid which can cause more harm than good >Exercise regularly makes sense right >Practice stress reduction techniques like yoga and meditation which may decrease inflammatory genes. stress produces cortisol. Chronic stress causes inflammation. >Get sufficient sleep Regardless of effect on longevity good sleep will just help you feel better >sleep deprivation can increase inflammatory cytokines. this is true >Challenge your brain with cognitively stimulating activities More of a thing for retirees. Thats why they do sudoku puzzles >Quit smoking That big "smoking kill" signs mandated by FDA is kind of for this reason. Damages the epithelium in your blood vessels and causes MI/stroke. Increases lung cancer. It doesn't apply to just tobacco but anything that can be smoked

90 points by gardenfelder 3y ago

>Researchers have unveiled the key role of the cGAS/STING molecular signaling pathway in driving chronic inflammation and functional decline during aging. The team discovered that blocking the STING protein suppressed inflammatory responses in aging cells and tissues, leading to improved function.

gessha 3y ago

In mice

everybodyknows 3y ago
> Using explants of human adipose tissue from individuals with obesity, in whom the adipose tissue accumulates senescent preadipocytes12, we confirmed that STING inhibition by H-151 suppressed the release of proinflammatory signals from senescent cells at the tissue level (Extended Data Fig. 3).

freilanzer 3y ago

First immortal mice when?

IIsi50MHz 3y ago
When no cats. (-: …okay, maybe a few other requirements.

rybosworld 3y ago

Is the key problem here that the inflammation is chronic? My understanding was that inflammation is a very necessary part of the healing process. I would have thought that blocking the inflammation process would be catastrophic for healing.

woleium 3y ago
I'd imagine there are times when it would be useful. I had assumed that inflammation was more to do with fighting infection than healing, but I may be wrong.
- maksimur 3y ago
  Doesn't inflammation happen when building muscle? Isn't muscle building a healing process?
- nradov 3y ago
  Inflammation plays a role in stabilizing damaged tissue and accelerating the healing process. This is one reason why the common practice of using ice to treat musculoskeletal injuries probably does more harm than good in most cases. https://www.outsideonline.com/health/training-performance/good-to-go-book-christie-aschwanden-questions-recovery/ https://www.outsideonline.com/health/training-performance/go...
kypro 3y ago
Yes, you're correct. You can inhibit inflammation, and some people do, but you'll almost certainly be increasing your risk for cancer and other diseases. The goal should be to decrease chronic baseline inflammation while maintaining a healthy inflammatory response.
michaelhoney 3y ago
Correct: chronic inflammation is bad, but acute (and often, localised) inflammation is part of the body’s healing mechanism.

jacknews 3y ago

So is there anything left for Mid-2023? We got AGI, pretty much, (it's artificial, it's general, and fairly intelligent by most standards), and in last few weeks, we might have room temperature superconductors, a cure for cancer, and now a cure for aging? Can't help but wonder if there's a connection, lol.

Brajeshwar 3y ago
They finally start using the tech buried millions of years ago by Who-Who-Must-Not-Be-Mentioned.
- jacknews 3y ago
  Right, I forgot all about the secret UFO recovery program now allegedly coming to light. Maybe it's all from there, lol.
wuming2 3y ago
Perhaps the first generated the next one and so on. Let’s wait for hallucinations now.
- jtbayly 3y ago
  Perhaps the rest of the mentioned amazing advancements are the hallucinations...
fallingknife 3y ago
Don't forget the totally unrelated UFO hearings in congress...
Phenomenit 3y ago
What are you referring to when you say cure for cancer?
- htp 3y ago
  I assume this is a reference to e.g. https://news.ycombinator.com/item?id=36982813 https://news.ycombinator.com/item?id=36982813

everybodyknows 3y ago

To spare you the animated ads, direct link: https://www.nature.com/articles/s41586-023-06373-1 https://www.nature.com/articles/s41586-023-06373-1

swamp40 3y ago

> More importantly, animals receiving STING inhibitors displayed significant enhancements in spatial and associative memory. I don't suppose there is some herbal STING inhibitor already available OTC?

tmikaeld 3y ago
There isn't, finding inhibitors (natural or synthetic) that can specifically target STING without disrupting other essential cellular processes is a challenge. However.. Resveratrol, a natural compound found in grapes and red wine, has been studied for its potential to modulate STING activity, though not the STING protein specifically (from what i can find). There's also speculation that the gut microbiota plays a role in modulating the immune system and it's possible that certain bacteria could influence STING activity.

roody15 3y ago

Just my take as a middle aged human watching myself and others age I see a connection with alcohol / inflammation and aging. From my experience: people who drink frequently age much worse and this could be related to inflammation. Alcohol is obvious poison but even drinking a beer here or there causes inflammation … let’s say you drink one beer a night after work … I think this exacerbates the aging process by leaving the body in constant inflamed state. This is based on nothing other than my own anecdotal observations

darkclouds 3y ago
So the next question is, what makes alcohol attractive in the first place and what does it deplete? Maybe the depletions are a clue? I've only got so many stem cells, so whilst it might seem logical to reduce inflammation to preserve the demand for stem cells, how can I increase my red bone marrow? Filgrastim is not an answer. Answers on a Postcard to:-
- gottorf 3y ago
  Puzzlah Towah, Hahvahd Squah
- roody15 3y ago
  What makes alcohol attractive. In my experience alcohol in many social situations helps people form a connection (cutting through layers of bs we masquerade around with). It helps people break the ice and form a bond .. both as just friends and also with possible love interests. The issue that I have seen is that we humans form habits (and addictions). So let’s say alcohol helped me make some friends in college and hook up with a lady friend who become a serious romantic long term partner. Your brain is like yeah .. she alcohol helps… and the inflammation issues take years before you notice any symptoms. Years later you just now associate alcohol with socializing and good time .. or even associate with relaxation. As you age and life is stressful this can dangerous because now your body has become dependent on this substance for mental relaxation / stress unwinding. Now you find yourself drinking by at home with no love interest and maybe just alone without friends. Fast forward now you find yourself overweight and having health issues … and your like man cannot believe this is happening to me .. aging sucks and I am unlucky. Your subconscious and habit do a good job of stopping you from making any connection that perhaps alcohol has been playing a role here. Side note: I am friends with a couple recovered alcoholics and am just basing my rambling response based on my own life experiences.

dsign 3y ago

Let's assume this is confirmed and that tomorrow an inhibitor that also works is found. How many decades from now until one can go to the doctor and get the inhibitor prescribed? Any bets?

deleted 3y ago
[deleted]

dazzaji 3y ago

I barely understand the actual research so I tried getting Claude 2 100k to walk me through it. It stresses that the findings are primarily important for guiding future research. Interestingly, when I then asked if there are any actions I could take today to avail myself of the findings I got what appears to be some reasonably well aligned suggestions. However, I’m way out of my depth here. Does anybody know if the following (or any part of the following) is sound or for that matter if it’s terrible? Here’s what I got: “ Here are some potential ways you could apply the findings from this study in your daily life: Diet: - Eat foods rich in antioxidants and anti-inflammatory compounds like curcumin (turmeric), catechins (green tea), and anthocyanins (berries) that may help reduce inflammation. - Consume foods rich in NAD+ precursors like nicotinamide riboside or tryptophan to potentially support mitochondrial function. - Follow an intermittent fasting regimen, which may enhance mitochondrial health and reduce inflammation. - Limit foods high in saturated fats, added sugars, and processed carbs that can promote inflammation. Supplements: - Take supplements that may inhibit cGAS/STING like quercetin, curcumin, green tea extract. However, speak to your doctor first. - Consider supplements to support mitochondria like CoQ10, nicotinamide riboside, and alpha-lipoic acid. Lifestyle: - Exercise regularly as it can reduce inflammation, improve mitochondrial function, and stimulate brain plasticity. - Practice stress reduction techniques like yoga and meditation which may decrease inflammatory genes. - Get sufficient sleep since sleep deprivation can increase inflammatory cytokines. - Challenge your brain with cognitively stimulating activities to potentially promote neuroplasticity. - Quit smoking, as it increases inflammation and oxidative stress. However, changes should be made cautiously and discussed with a health professional. While the study provides promising areas to target, more research is still needed to confirm effects in humans.”

hkatx 3y ago
NAD+ is available in a supplement form very popular in longevity community. IF/intermittent fasting induces autophagy. Also popular in longevity/health folks. Our diets are so poor, I wonder if the benefit comes from eating less or by sticking to a feeding window. But the evidence is for it. It can't hurt you as long as you meet your nutritional requirement during your feeding window. >Limit foods high in saturated fats, added sugars, and processed carbs that can promote inflammation. Most metabolic diseases first line of treatment is diet modification. >cGAS/STING like quercetin, curcumin, green tea extract. However, speak to your doctor first. Do talk to you doctor. Quercetin metabolism does interfere with hormone (I know in men) But it is inflammatory. Green tea extract could hurt kidney so be careful with the source. >CoQ10, nicotinamide riboside, and alpha-lipoic acid CoQ10 is a co-enzyme recommended for heart patients. In healthy adults it can't hurt. Alpha lipoic acid is an essential fatty acid. Salmon/tuna is rich in it or also available in supplement. Do take a quality source because most fatty acid supplement is rancid which can cause more harm than good >Exercise regularly makes sense right >Practice stress reduction techniques like yoga and meditation which may decrease inflammatory genes. stress produces cortisol. Chronic stress causes inflammation. >Get sufficient sleep Regardless of effect on longevity good sleep will just help you feel better >sleep deprivation can increase inflammatory cytokines. this is true >Challenge your brain with cognitively stimulating activities More of a thing for retirees. Thats why they do sudoku puzzles >Quit smoking That big "smoking kill" signs mandated by FDA is kind of for this reason. Damages the epithelium in your blood vessels and causes MI/stroke. Increases lung cancer. It doesn't apply to just tobacco but anything that can be smoked