i000

9 ms·

61.
by i000 7y ago
One of the biggest challenges for studying telomere biology in the context of human aging, is that mice are quite different from humans in terms of their telomere structure. The shortes mouse telomere is longer than the longest human one h
62.
by i000 7y ago
As a faculty running a lab in human genomics /genetic I would say either join a lab which needs your skills or work for a univeristy in support of their IT and high-performance computing needs. People with computational skills, an inte
63.
by i000 7y ago
23andMe does genotyping not sequencing
64.
by i000 8y ago
This is precisely Bill Gates attitude, he called it "cute" https://www.forbes.com/sites/williampentland/2011/05/05/bill...
65.
by i000 8y ago
So a team of inexperienced developers made a system that mostly worked with some hiccups, could be debuged by an expert in 1 day, and fixed on a tight launch timeline. Looks like a success story!
66.
by i000 8y ago
What is "incredible" about using plastic containers to hold food?
67.
by i000 8y ago
I would suggest you do not use your personal failures and frustrations as justification to call other researchers work a waste of time. Please go ahead and explain to us how their contribution to science is a waste of time and money (you co
68.
by i000 10y ago
All University IT departments I have interacted with were terrible too. Universities simply cannot pay market-level salaries for IT staff because it would turn the whole pay-pyramid upside-down. The ones who stay, spend most of their time m
69.
by i000 10y ago
Sooo... I'm guessing this fits into what Brendan Iribe was talking about in his recent blog post, when he mentioned that the company wanted to "accelerate [their] roadmap"? From what others have mentioned it sounds like Hugo
70.
by i000 10y ago
They might have removed the headphone jack, but they've added quite a lot in the new iPhone: - New generation haptic feedback - Improved camera system and dual cameras for the Plus - Stereo speakers - A10 Fusion SoC makes the 7 the fas
71.
by i000 10y ago
Another example is how patient outcomes improve with the size of the healthcare facility a.k.a patient volumes e.g. http://www.mexicobariatricsurgerycenters.com/analysis-bariat...
72.
by i000 10y ago
The syntax is very concise and cryptic, but what is messy about dt[i,j,k]? data.table transformed the way I do analysis. Honestly probably 75% of my lines have are dt[] calls. It allows me to analyze on 500M row data.sets routinely on a pow
73.
by i000 10y ago
> the antique instrument is definitely the more versatile Not definitely. Only subjectively with an n=1 and botched experimental design. Please repeat blinded, a statistically-significant number of times with different violonists.
74.
by i000 10y ago
This is most likely a form of hereditary colon cancer e.g. Lynch syndrome. It is caused by a germline (inherited) mutation in one of the genes that repair random mutations associated with replication (e.g. the MLH1). Because colon cells div
75.
by i000 10y ago
Another example are Laments by a great Polish 16th century poet (Kochanowski). https://en.wikipedia.org/wiki/Laments_(Kochanowski)
76.
by i000 10y ago
Please, your statement is so ambiguous that it makes almost no sense. 1. Which mouse? An inbred laboratory possibly immunodeficient strain, a genetically engineered mouse to GET cancer at a high rate, or maybe a wild type free-range mouse
77.
by i000 10y ago
Apparently there are tree pruning machines with a similar design: https://youtu.be/CpdZyJ0Y1jE?t=472
78.
Software error doomed Japanese Hitomi spacecraft(nature.com)
2 points by i000 10y ago|1 comments
79.
by i000 10y ago
As someone who works at the bioinformatics end of a clinical cancer sequencing operation, and someone familiar with the MSKCC operation (they are doing good work with their IMPACT assay) I have to say that the landscape of matching patient
80.
by i000 11y ago
It is actually possible to do this (the gaits are discovered not programmed): https://www.youtube.com/watch?v=yci5FuI1ovk
81.
by i000 11y ago
I have to say that PDs attached read-only to multiple VMs is a very important part of my pipelines. And also a distinguishing feature of GCE. Clound Dataflow on the other hand is difficult to use in practice - one of the main reasons is t
82.
by i000 11y ago
In our case Google was very proactive and willing to sign a BAA. But the terms of those agreements have to satisfy both partners which for some reason ultimately did not happen.
83.
by i000 11y ago
I agree the API is at this point is rather limited and it is difficult to use it in a way that would conveniently or efficiently replace any part of a genomic pipeline. But I think google is onto something. If they manage to deconstruct BAM
84.
by i000 11y ago
Of course we did this, but cost is not the only consideration. Frankly, CPU-hours and TB-years are still within 5-10% of the total cost providing sequencing results to the patients. What is really important is that the cloud allows us to de
85.
by i000 11y ago
I work at an academic institution that generates and analyzes large amounts of genomic data (clinical sequencing of cancer patients). We were really impressed with the Google cloud and executed several large proof-of-concept projects on it.
86.
by i000 11y ago
I really wanted to cry when I saw what a 4K monitor did to my KDE4 desktop... - It is much worse than I expected and not even remotely close to being finished: https://community.kde.org/KDE/High-dpi_issues
87.
by i000 11y ago
Thanks. Considering it was more of a prank from the beginning I am not surprised to see it abandoned ;)
88.
by i000 11y ago
They can't do it;), my friend (Anson Parker) owns a patent: http://www.google.com/patents/US20090042974 "It is the ambition and intention of authors that tactical usage of this broad-sweeping technique may r
89.
by i000 11y ago
You should not forget about oncoviruses (e.g. EBV, HPV), also many oncogenes have viral homologs (e.g. RAF genes, https://en.wikipedia.org/wiki/C-Raf )
90.
by i000 11y ago
I am aware of this study. Funny, how they show expression in deltaCT to make it appear higher in cancer ;). But regardless, the marker has a specificity of 0.62 - really that excellent? Such a high false-positive rate does not belong anywhe

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