3 ms·

One of the biggest challenges for studying telomere biology in the context of human aging, is that mice are quite different from humans in terms of their telome

by i000 7y ago

One of the biggest challenges for studying telomere biology in the context of human aging, is that mice are quite different from humans in terms of their telomere structure. The shortes mouse telomere is longer than the longest human one https://www.ncbi.nlm.nih.gov/pubmed/23956466 https://www.ncbi.nlm.nih.gov/pubmed/23956466

no_identd 7y ago
Sure, but we have way more research on this already, from humans: http://doi.wiley.com/10.1002/jez.b.20006 http://doi.wiley.com/10.1002/jez.b.20006 Stindl, Reinhard - Is telomere erosion a mechanism of species extinction? (2004) http://link.springer.com/10.1007/s00114-014-1152-8 http://link.springer.com/10.1007/s00114-014-1152-8 Stindl, Reinhard - The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters (2014) http://molecularcytogenetics.biomedcentral.com/articles/10.1186/s13039-016-0224-1 http://molecularcytogenetics.biomedcentral.com/articles/10.1... Stindl, Reinhard - The paradox of longer sperm telomeres in older men’s testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline (2016) more here: http://telomere.at/publications.html http://telomere.at/publications.html also some old-as-fuck news coverage (2004): https://www.theguardian.com/education/2004/apr/08/science.highereducation https://www.theguardian.com/education/2004/apr/08/science.hi... https://www.newscientist.com/article/mg18224421.400-chromosome-clock-ticks-out-our-fate/ https://www.newscientist.com/article/mg18224421.400-chromoso... oh and, a letter where Stindl outlines the problem in detail: https://www.researchgate.net/profile/Reinhard_Stindl/publication/280049041_The_reanalysis_of_three_large_datasets_uncovers_progressive_telomere_erosion_between_healthy_human_generations_and_supports_an_11-year-old_model_of_telomere-driven_macroevolution/links/55a5467808ae81aec9134810.pdf https://www.researchgate.net/profile/Reinhard_Stindl/publica... Stindl, Reinhard - The reanalysis of three large datasets uncovers progressive telomere erosion between healthy human generations and supports an 11-year-old model of telomere-driven macroevolution (2015) I find it EXTREMELY strange that the OP paper cites NONE of these papers. Like, what the hell?

by i000 7y ago

no_identd 7y ago

Sure, but we have way more research on this already, from humans: http://doi.wiley.com/10.1002/jez.b.20006 http://doi.wiley.com/10.1002/jez.b.20006 Stindl, Reinhard - Is telomere erosion a mechanism of species extinction? (2004) http://link.springer.com/10.1007/s00114-014-1152-8 http://link.springer.com/10.1007/s00114-014-1152-8 Stindl, Reinhard - The telomeric sync model of speciation: species-wide telomere erosion triggers cycles of transposon-mediated genomic rearrangements, which underlie the saltatory appearance of nonadaptive characters (2014) http://molecularcytogenetics.biomedcentral.com/articles/10.1186/s13039-016-0224-1 http://molecularcytogenetics.biomedcentral.com/articles/10.1... Stindl, Reinhard - The paradox of longer sperm telomeres in older men’s testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline (2016) more here: http://telomere.at/publications.html http://telomere.at/publications.html also some old-as-fuck news coverage (2004): https://www.theguardian.com/education/2004/apr/08/science.highereducation https://www.theguardian.com/education/2004/apr/08/science.hi... https://www.newscientist.com/article/mg18224421.400-chromosome-clock-ticks-out-our-fate/ https://www.newscientist.com/article/mg18224421.400-chromoso... oh and, a letter where Stindl outlines the problem in detail: https://www.researchgate.net/profile/Reinhard_Stindl/publication/280049041_The_reanalysis_of_three_large_datasets_uncovers_progressive_telomere_erosion_between_healthy_human_generations_and_supports_an_11-year-old_model_of_telomere-driven_macroevolution/links/55a5467808ae81aec9134810.pdf https://www.researchgate.net/profile/Reinhard_Stindl/publica... Stindl, Reinhard - The reanalysis of three large datasets uncovers progressive telomere erosion between healthy human generations and supports an 11-year-old model of telomere-driven macroevolution (2015) I find it EXTREMELY strange that the OP paper cites NONE of these papers. Like, what the hell?