hirenj

16 ms·

121.
by hirenj 7y ago
-oma is a suffix that means tumour. E.g. lymphoma. -sclerosis is a hardening. E.g arthrosclerosis for a hardening of joints.
122.
by hirenj 7y ago
This could also be "fixed" by dietary supplement, but you run the risk of aggravating your immune system. One way to introduce this back into the system is by consuming red meat. The conclusion from this is EMPHATICALLY NOT that t
123.
by hirenj 7y ago
As far as I remember, malaria comes in via glycosaminoglycans, and not our sialylated glycans. It could very well be related to our symbiosis with bacteria however. Edit: I forgot the earlier work demonstrating Plasmodium specificity to Neu
124.
by hirenj 7y ago
We could probably edit in a working copy, but I wouldn't be so quick to do that: Sialic acids are all over our cells, and we don't understand what the difference is between the two sialic acid types in terms of impact on molecular
125.
by hirenj 7y ago
It's likely there for either bacterial warfare, or degradation/metabolism of the mucus layer in the gut (or both).
126.
by hirenj 7y ago
The whole ABO system really hints at just how tricky prediction of activity from amino acid sequence is. The transferase that puts the A (GalNAc) or B (Galactose) sugar on switches specificity at the slightest hint of a sequence variation.
127.
by hirenj 8y ago
You’re on the right track with the inhibitor / activator method to target Klotho. It's a funny protein. It forms a complex with FGF23 for binding to the FGFR. My bet is that there's some relationship to ECM remodeling and the
128.
by hirenj 8y ago
It would be great if there was an "expert" mode on this, with a bit more detail on the coat protein structures. Modern molecular biology is so abstracted, you often lose sense of the actual scales of things. Being able to look at
129.
by hirenj 9y ago
I spent at least half an hour trying to figure out which gene it is. I have a sneaky feeling I have read this story before, and managed to track the gene down there, but not this time. You'd think that if they were serious about tackli
130.
by hirenj 9y ago
Lots more places things can go wrong not only before protein is synthesised, but also after too. An example is anything that hits a regulatory region for a protein (i.e. outside protein coding region). Chances are phenotype may not be as st
131.
by hirenj 9y ago
I can't speak for all the genes on that list, but I wouldn't go around knocking out FUT2 just yet. We don't know the full extent of biological roles for it, and the functionality is probably redundantly encoded in multiple ge
132.
by hirenj 10y ago
I have just recently got through a migration from express to a lambda based stack. In the end, performance is pretty good (once the lambdas are warm), but there were a few tricky parts, but nothing impossible. Serving backend requests is ea
133.
by hirenj 10y ago
It's funny to consider that these errors slipped past the peer review stage. It really highlights the major issue with reviewing source code published as part of an analysis. If there aren't enough resources / skilled eyes to
134.
by hirenj 11y ago
I went to the article to try and dig up information about the orthologues, but as is kind of par for the course these days, the meat of the useful information is not readily available. If you go to the supplementary information, you can fin
135.
by hirenj 11y ago
This definitely looks like something I need to check out. I do a lot of one off analysis for small bioinformatics projects,and I've taken to sharing results in the Microsoft ecosystem via OneNote. I've wrapped knitr into my own li
136.
by hirenj 11y ago
I actually found this to be a very timely paper, as the set-up of an RNA-seq workflow has been added to my to-do recently. One thing I am not keen on is the systems administration part of the work, and I like the idea of being able to spin
137.
by hirenj 12y ago
It seems like the number of options for in-browser molecular visualisation have increased recently, which makes me feel all the better for not getting around to integrating molecular vis into a protein centric tool I've been working on
138.
by hirenj 12y ago
Link to the actual paper if anyone is interested: http://www.ncbi.nlm.nih.gov/pubmed/25233221
139.
by hirenj 12y ago
I missed the discussion on this last time this came up, but this fits squarely within my area of research, so it would be remiss of me not to pass comment. The Reddit link from Evgeny does a pretty good job of giving the gist of the researc
140.
by hirenj 12y ago
Does anyone know of a simple script to get the signal strength of the bluetooth connection on OS X? I've been putting together pieces of this app functionality, but I'm stuck at a scriptable / command line bluetooth program.
141.
by hirenj 12y ago
I had a conversation along these very lines today. The hard question is how to fund such a thing. A lot of funding seems to be for the individual researcher to start a group, or for large consortia to work on a project, with precious little
142.
by hirenj 12y ago
I will do so! They'll be short on content to start with, since we've still got to do the leg work to fill in the data. I don't really get why other biologists shut down, but I figure if we put together some good cognitive (an
143.
by hirenj 12y ago
Hi Matt - It's inspiring to read more about your story, and that you've been making some progress with Hud Freeze, with some potential results from an inhibitor? Hud Freeze came to visit our lab (he's on the steering committe
144.
by hirenj 13y ago
I'm glad someone mentioned the carbs here – it gives me a good excuse to pipe in. Maltodextrin is a ludicrous oversimplification of carb intake. The carb intake in whole foods is ridiculously complex, given the ubiquity of the variety of ca
145.
by hirenj 14y ago
Mitochondria are pretty important (as is most of the junk in our cells for that matter). I'd be less wary of the use of mitochondria in popular science - it's shorthand for talking about the energy metabolism pathway, and doesn't indicate o
146.
by hirenj 14y ago
I'd agree here – given the nature of the digestive system, and the different things that are absorbed at different points across the digestive tract, I'd say that throwing it all in, ready for the body to soak up is probably a bad idea. Fur
147.
by hirenj 14y ago
I would appreciate it you'd elaborate on your first point about mitochondria here. I'm intrigued to find out why this term is highly suspicious. Are there other organelles that are less crank-like to you?
148.
by hirenj 14y ago
Things look pretty weird here: http://btlondon2012.co.uk/pano.html?view.hlookat=-96.9453&#3...
149.
by hirenj 14y ago
I've always hoped that the Hitchhikers (Zaphod Beeblebrox) method for initiating an interaction with computers (saying "OK [computer]") would catch on.
150.
by hirenj 14y ago
In response to the comments about whether this would provide incentive to those that would practice science, I would argue that it's probably not the point. Rather, it rewards those who think big and encourages risk-taking, both qualities t

More ›