3 ms·
I missed the discussion on this last time this came up, but this fits squarely within my area of research, so it would be remiss of me not to pass comment. The
by hirenj 12y ago
I missed the discussion on this last time this came up, but this fits squarely within my area of research, so it would be remiss of me not to pass comment. The Reddit link from Evgeny does a pretty good job of giving the gist of the research.
The big puzzle here is the precise mechanism by which this kind of thing can occur. To some degree, the binding of particular sugar-binding proteins to these newly incorporated sialic acids could perhaps influence cellular processes. What exactly is binding the sugars, and which molecules the sugars are incorporated onto will help with understanding the cellular processes.
The paper linked is an elaboration on Ajit Varki's work - but there's a lot more we don't understand about it than we do understand before we go about making conclusions. For what it's worth, I believe that Varki is not eating red meat [1]. I will try to get a look at his plate at the next conference dinner.
edit: [1] I'm not sure if he previously ate meat, so I removed the "now".
- samatman 12y agoI'm curious about the validity of a mouse model for this subject. I remember early reports that rapeseed oil causes cancer in rats, followed by the discovery that feeding rats large amounts of any oil gives them cancer, because it's a bad model. I don't think of small rodents as being particularly carnivorous, and as eating bugs and small bites of rotten meat when they do eat animals. Could this be affecting the results of this study?