You’re on the right track with the inhibitor / activator method to target Klotho. It's a funny protein. It forms a complex with FGF23 for binding to the FGFR. M

You’re on the right track with the inhibitor / activator method to target Klotho. It's a funny protein. It forms a complex with FGF23 for binding to the FGFR. My bet is that there's some relationship to ECM remodeling and the function of Klotho, given it's relationship to glucuronidases. That's just a guess though, but it's very interesting.