I actually found this to be a very timely paper, as the set-up of an RNA-seq workflow has been added to my to-do recently. One thing I am not keen on is the sys

I actually found this to be a very timely paper, as the set-up of an RNA-seq workflow has been added to my to-do recently. One thing I am not keen on is the systems administration part of the work, and I like the idea of being able to spin up machines easily using docker. I'm not sure about your comment about Big Data. If it turns out every hospital will have a next-gen sequencer, it seems to me the pipelines are really important, and having someone else working out the logistics sounds good to me. I'm curious as to what you consider the tougher big data problem. From where I sit, I consider this to be a complex data problem, and the issues of data size are simply solved by better/faster computing.