Lots more places things can go wrong not only before protein is synthesised, but also after too. An example is anything that hits a regulatory region for a pro

Lots more places things can go wrong not only before protein is synthesised, but also after too. An example is anything that hits a regulatory region for a protein (i.e. outside protein coding region). Chances are phenotype may not be as strong because you may end up with only partial transcriptional loss. I'm guessing it's super critical where you have developmental diseases, and you hit a TF binding site specific for development.