entee

46 ms·

151.
by entee 7y ago
How many of those trips are cuttable? Maybe one or two business trips. And businesses would already rather teleconference these days if the trip is really avoidable. Given how cumbersome and expensive flying is already, I'm not sure th
152.
by entee 7y ago
I take your point, though I'm not sure taxes are the answer. Very rarely is air travel even close to the cheapest option (in the US here, Europe has low cost airlines that may shift the math). Although I'm pretty well off as compa
153.
by entee 7y ago
Keep in mind that as a fraction of emissions, air travel is actually quite small, about 2-3% [1] (and this is from a harsh article). There's some concern that as the industry grows (roughly 5% a year) and other sectors decarbonize, air
154.
by entee 7y ago
My main question is whether when someone takes a CBC how often that's the only test. If you're looking for other markers (A1C, Potassium, any number of standard panel stuff) you probably need to take a full size blood draw so I&#x
155.
by entee 7y ago
It's hard for me (especially having never worked at google or followed the story closely) to judge on the merits here, but I'm curious on the broader subject. It seems many tech workers have strong opinions about politics or how w
156.
by entee 7y ago
It's actually a version of Carbon that has interesting and strange behavior, so I'm not sure it's inaccurate.
157.
by entee 7y ago
They are submitting an IND, which is great but they still have Phase 1, 2 and 3 to go. It's also a cell therapy so if it works, it's likely to be quite expensive to receive. That said, if it works, it's a wonderful breakthrou
158.
by entee 7y ago
Was SequelPro trying impute any field types? That could have been causing the crash when faced with a large file.
159.
by entee 7y ago
Oh of course, but those who had not yet been poisoned were protected. I guess I'm agreeing with you and adding the caveat that nearly everyone is already poisoned.
160.
by entee 7y ago
I think you’re right but the problem is that this time it’s different: maybe the rights will arise, but for many people it’ll be too late. Assume there is a privacy law enacted, all the data that was previously collected is still around. So
161.
by entee 7y ago
It looks like the Fenix 3 or maybe a Fenix 5, range there is $400-$800 or so. Unclear whether they're issuing the MARQ watches. The Fenix series does everything the MARQ does but for 1/4 the price. The most expensive flight orient
162.
Ask HN: Raised a Seed, Now What?
1 points by entee 7y ago|0 comments
163.
by entee 7y ago
I won’t defend the marketing very much, I think there’s a lot wrong in pharma marketing. The only (very slight) defense I’d make is that marketing when done well brings in more resources than it costs and helps the broader org. That said, i
164.
by entee 7y ago
Yes :) I've heard of some of these mechanisms, I think they're a decent balance. All of these issues are fairly complex, it's helpful to have context.
165.
by entee 7y ago
You might be right to a certain extent, but keep in mind just how expensive trials are. Many millions sometimes even into the 10s of millions of dollars for a single trial depending on the indication. That's a ton of money. For referen
166.
by entee 7y ago
One small wrinkle: what if there's an old existing compound that seems to work well for an different indication than it was originally approved for? It would be good to run the phase 3 trial (possibly phase 2 as well) but that's g
167.
by entee 7y ago
It's important to understand why the efficiency is going down, and it's not because the companies themselves suck more every year. It's because of two main drivers: 1.) The easy targets are mostly gone. All the biology we und
168.
by entee 7y ago
Purdue's new delivery mechanisms were actually a huge benefit to the right patients. The problem is they abused it and actively sold the drug to the wrong patients repeatedly and worked hard to push back oversight.
169.
by entee 7y ago
This dynamic already exists in diagnostics. There's a huge second mover advantage in diagnostics because it's relatively hard to patent a diagnostic effectively. I know a few people in diagnostic companies that have very much sour
170.
by entee 7y ago
There's a huge issue with pricing today. It used to be that drug companies were ethical about the "your money or your life" nature of medicine. Merck once even gave a drug away for free because it was the right thing to do [1
171.
by entee 7y ago
CFRP was interesting technology. I don’t know enough about how new it was, but building it out as an industrial process at that scale was potentially quite useful. At the time (2013) there was what? The volt, the Model S. That’s pretty much
172.
by entee 7y ago
That makes sense. I think most people underappreciate how polyclonal cancer is. Every tumor isn't one cell, it's dozens or hundreds of different types of cell, which makes it extremely hard to cover all the possible escape paths f
173.
by entee 7y ago
Cancer favoring glucose has been known for a very long time, this is called the Warburg Effect: https://en.wikipedia.org/wiki/Warburg_effect_(oncology) Interesting new pharmacology for sure, but the end of the article
174.
by entee 7y ago
Oh interesting. It's basically working in a similar way to Colchicine then. Colchicine blows up the microtubules so the chromosomes don't segregate properly. The combination of the two might be effective, though I suspect there&#x
175.
by entee 7y ago
There are even DNA and cell division targeted agents. Colchicine kills cells by messing with DNA segregation between dividing cells. This one appears to promote division? Though I haven’t read all the details.
176.
by entee 7y ago
That statement is uncontroversial, though keep in mind it's also not completely rejecting the importance of H-bonds. A GC basepair is still more stable than an AT basepair due to 3 H-bonds on the GC and only 2 for the AT. However, to c
177.
by entee 7y ago
A little background on one of the authors: Carlos Bustamante (there are two science-famous ones, this one is NOT the one who analyzed Elizabeth Warren's DNA test) is a pioneer in structural analysis of DNA, particularly using optical t
178.
by entee 7y ago
Extensive studies on the thermodynamics of DNA helix formation have long shown that there's a very important contribution for base stacking [1]. This isn't news. What is new in this study is that they explore how hydrophobic inter
179.
by entee 7y ago
This, so much this. It's very hard to make an antibiotics company work, not so much because you can't make money on the pill itself, but because it will never actually get used unless the infection is dire. This means that your ma
180.
by entee 7y ago
Were the results published or suppressed from publication? I'm sure the University has some sort of IP department and the patent for the compound(s) would belong to the university. That patent should also be public information. If the

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