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There are even DNA and cell division targeted agents. Colchicine kills cells by messing with DNA segregation between dividing cells. This one appears to promote
by entee 7y ago
There are even DNA and cell division targeted agents. Colchicine kills cells by messing with DNA segregation between dividing cells. This one appears to promote division? Though I haven’t read all the details.
- gus_massa 7y agoI think it doesn't promote cell division directly. IIUC this make the cell during the division to not wait until the chromosomes are correctly split, so the new cell have a high chance of getting a wrong number of chromosome and die. Since the cell doesn't wait until everything is in order, the division is faster. Form the abstract: https://mct.aacrjournals.org/content/18/10/1696 https://mct.aacrjournals.org/content/18/10/1696 > In in vivo pharmacodynamic experiments, BOS172722 potently inhibits the spindle assembly checkpoint induced by paclitaxel in human tumor xenograft models of TNBC, [....] I think the key part is "spindle assembly checkpoint" https://en.wikipedia.org/wiki/Spindle_checkpoint https://en.wikipedia.org/wiki/Spindle_checkpoint
- entee 7y agoOh interesting. It's basically working in a similar way to Colchicine then. Colchicine blows up the microtubules so the chromosomes don't segregate properly. The combination of the two might be effective, though I suspect there's a toxicity issue or something else I'm missing.