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Taurine deficiency as a driver of aging
- _hyn3 3y agoInteresting, so Red Bull is actually healthy?
- Grazester 3y agoWas actually needing some caffeine to up me toda. I debated having a sugar free Red Bull but even the sugar free ones are not great for you due to the sucralose
- Blackthorn 3y agoI know I won't change anyone's already set opinions here, but for anyone reading this and not sure what is being discussed: there's absolutely nothing wrong with consuming sucralose.
- blips 3y agolook here bud, they confirmed it in a pitri dish. I think we can proceed to throw all the food in my house out now
- psychphysic 3y agoI personally find what poses a risk to my health (actually my waist line) is if I have one sugar free drink (sweetened) I just crave more. I don't know if the sugar mitigates some effect, or it's purely driven by psychology and me unconsciously feeling unrestricted in consuming sugar free drinks. But I see a clear effect in me. I even tried coke life when it existed to see if I managed it better but it was too short lived to know.
- valianteffort 3y agoYes your blood sugar is regulated by insulin
- c22 3y agoFor anyone reading this looking for a more nuanced take: [0]. [0]: https://usrtk.org/sweeteners/sucralose-emerging-science-reveals-health-risks/ https://usrtk.org/sweeteners/sucralose-emerging-science-reve...
- ohgodplsno 3y agoThere might be. A research shows it is genotoxic at times. https://healthnews.com/news/chemical-in-artificial-sweetener-may-damage-dna/ https://healthnews.com/news/chemical-in-artificial-sweetener...
- Fauntleroy 3y agoI have extremely strong anecdotal evidence that sucralose is toxic to my gut fauna. Two years of suffering are enough to convince me, but I'm hopeful to see the research that confirms it sooner than later.
- Blackthorn 3y agoHey, if you've found it's bad for you, then by all means don't consume it! The nice thing about sweeteners, unlike a lot of other food stuff, is that there's a lot of options out there.
- Fauntleroy 3y agoYes, I know this. However you're making the blanket statement that it's harmless, and I simply have to push back on that. If it affected me this negatively, it's surely causing harm to others.
- Blackthorn 3y agoI mean my wife is allergic to lactose, but I wouldn't say lactose is anything but generally harmless.
- giardini 3y ago"...but I wouldn't say lactose is anything but generally harmless." Obviously you've never lain (I cannot call it sleep) with a lactose-intolerant SO after an evening of milk-laden feasting (loves Indian desserts which, with Indian meal included, ratchets up the noxious undercover methane emissions by about 10,000%). The dog even moved out of the bedroom!8-((
- heisenbit 3y agoThis is actually a good point: The fact that it does not get metabolized by the body does not mean it does not get metabolized by some valuable bacterial symbionts.
- baremetal 3y agoSucralose found in common sweetener damages DNA, may cause cancer [1] [1] https://www.medicalnewstoday.com/articles/sucralose-found-in-common-sweetener-damages-dna-may-cause-cancer https://www.medicalnewstoday.com/articles/sucralose-found-in...
- inciampati 3y agoI've recently been wondering if sucralose isn't the agent driving a recent increase in cancer cases among young people. Putting lots of chlorine atoms in your sugar is not a good idea. We got my mom to stop using it when she developed some bad rashes on her hands. Turns out, sucralose was the cause.
- hombre_fatal 3y agoReality: At the very highest concentrations of the sucralose compound tested in this study, using cells in petri dishes, one marker of gene damage was slightly elevated
- baremetal 3y agoIn reality, I try to minimize my exposure to known carcinogens. This one is quite avoidable.
- hombre_fatal 3y agoIf your epistemic standard is based on what happens to a single marker of cells in a petri dish at concentrated levels of exposure, then the list of foods you should avoid is endless. You couldn't even eat meat nor all sorts of vegetables even though those foods improve human health outcomes in clinical trials. For example, that experiment can't even capture the most basic hormetic effect.
- snapcaster 3y agoYou don't know this! I don't take issue with you consuming it but you absolutely shouldn't have confidence that there aren't negative effects from consuming something humans never had to adapt to. Just say "we don't know of anything wrong with consuming it"
- extasia 3y ago"snapcaster, flashback counterspell" "gg"
- Blackthorn 3y agoThese artificial sweeteners are among the most studied chemicals in the world. At some point you've gotta say okay, they're fine, or okay, they're not.
- throwaway290 3y agoIf artificial sweeteners are so well studied as you claim then why sucralose was found to damage DNA while erythritol was linked to heart attacks in studies just this year? Sugar or nothing for me personally.
- detrites 3y agoStudied by whom for what goal? They're also some of the most astutely-avoided substances, with various products proudly proclaiming they don't contain them. Such markets could well potentially exist due to user experience trumping studies.
- Blackthorn 3y agoSo I take it you're on the "okay, they're not" side of that divide? I mean, how many more decades does one need to really make a decision on these?
- xcv123 3y agoThere are studies for and against artificial sweeteners. There are studies funded by industry. There is such a thing as corruption in science and corruption in regulatory agencies. The global artificial sweetener market size is $7 Billion. https://www.healthline.com/health-news/this-common-sugar-substitute-may-damage-your-dna-and-increase-your-cancer-risk https://www.healthline.com/health-news/this-common-sugar-sub...
- Eumenes 3y agohttps://www.mirror.co.uk/news/world-news/cancer-warning-over-cell-destroying-30144208 https://www.mirror.co.uk/news/world-news/cancer-warning-over...
- deleted 3y ago[deleted]
- topicseed 3y agoWhat's wrong with sucralose?
- alamortsubite 3y agoThere's recent research showing it's genotoxic in even moderate quantities: https://news.ncsu.edu/2023/05/genotoxic-chemical-in-sweetener/ https://news.ncsu.edu/2023/05/genotoxic-chemical-in-sweetene...
- inciampati 3y agoPutting chlorine in sugars that get metabolized seems to be a very bad idea because it leads to some very radical compounds getting loose in the cell.
- slashdev 3y agoSucralose isn’t metabolized. The body excretes it in the same quantity you take in. Also table salt is half chlorine and not a health issue (at least not because it contains chlorine). The body is complex.
- lostmsu 3y agoAnecdata: a heavy (2 x 8oz cans/day) consumer of Red Bull I got sleep problems starting around 34. Can't be sure they are related, but Red Bull is definitely the main suspect.
- WastingMyTime89 3y agoThat’s a high amount of sugar. That by itself can’t be too good.
- ChuckNorris89 3y agoI doubt the sugar alone is to blame and not the high caffeine content.
- WastingMyTime89 3y agoThere is not that much caffeine in Red Bull surprisingly. It’s a lot compared to a soda but it pales if you compare it to coffee: it’s approximately half as much as what’s in an espresso. Caffeine-wise, drinking two cans should be fine (provided you don’t drink a ton of other caffeinated beverages). Honestly my first guess here is that we are in the presence of a confounding variable. I can somewhat imagine the life style which goes with having to drink two cans of Red Bull everyday. The cause of the sleep problems starting at the beginning of early middle age might actually be found here.
- jstarfish 3y agoI don't think it's anything confounding; it's likely just age. Old people are really sensitive about drinking caffeinated coffee late in the day for reasons I never understood until my mid-30s, where suddenly I had to watch soda intake after 6pm or I'd get insomnia. (Also, use phone/monitor night mode and don't do anything intense within 1hr of bed-- no gaming, no exercise, no forums, no outrage-inducing news, etc. Wind down with something boring.)
- lostmsu 3y ago
- opisthenar84 3y agoSo... drink more Red Bull?
- Scoundreller 3y agoOr think of mass-market cat food as a dietary supplement
- SketchySeaBeast 3y agoThat's good to know my retirement plan will keep me looking young.
- readthenotes1 3y agoBad plan Cat food is incredibly expensive!
- SketchySeaBeast 3y agoWell sure, but it'll also keep me clear of urinary crystals.
- Scoundreller 3y agoAt the low end of the market (had a cat that lived 19y on this stuff), Meow Mix original is 3500 calories per kg. A 10kg bag costs $35 in Canadian dollars or about US$28. So just a couple dollars a day for an adult.
- Blackthorn 3y agoInflation is a funny thing. I once had a fencing coach who ate cat food because it was cheap and the school didn't pay him a living wage.
- gnulinux 3y agoCat food has tons of taurine in it because cooking food destroys taurine but unlike humans cats cannot produce taurine themselves.
- redkinght99 3y agoTaurine? I've been jacking myself full of that since Middle School! Thanks RedBull! Jokes aside, This feels like one of "Wine is Good for you" In moderation and other fine point details. Not buying it.
- throwaway888abc 3y agoCan't stop laughing. The day after is terrible, but with the aging factor relevated - here is the recipe of favorite anti-aging cocktail Jäger Bomb Ingredients 1 1/2 ounces Jägermeister Liqueur 1/2 (8.4-ounce) can Red Bull energy drink https://www.thespruceeats.com/jager-bomb-recipe-759713 https://www.thespruceeats.com/jager-bomb-recipe-759713
- winddude 3y agoor a nice steak. 1 - 14oz steak, season with tiptop steak seasoning, grill 3-4mins per side on med heat. let rest 5 mins. enjoy.
- fullspectrumdev 3y agoThe nice steak and its sides provide the essential… stomach lining… to cope with the jägerbomb
- numpad0 3y agoOctopus and squids works too. Buy boiled and/or pre-sashimi’d, open package, slice as needed and serve with soy sauce. Somehow I hated them as a child. Maybe it was too much for my body back then.
- LuckySalamander 3y agoI've always enjoyed Jäger bombs half and half. Then again, no one survives living in Champaign, IL without getting well acquainted to Jägermeister.
- selectodude 3y ago
- labrador 3y agoThe Monster zero Ultra drinks I like (no sugar) list energy ingredients as taurine, L-Carntine, caffeine, inositol. I'm bipolar and they make me somewhat manic, which I like because I get creative, but I keep thinking I shouldn't drink them because everyone tells me they are unhealthy. Maybe not?
- strawhatguy 3y agoCan't make decisions on what everyone else says. Drink what you want!
- 2023throwawayy 3y agoYea! Nutritional science be damned! Smoke crack too! Can't make decisions on what everyone else says after all.
- labrador 3y agoYou don't believe in the "wisdom of crowds" I take it https://en.wikipedia.org/wiki/The_Wisdom_of_Crowds https://en.wikipedia.org/wiki/The_Wisdom_of_Crowds
- SketchySeaBeast 3y agoWell, "healthy" and "unhealthy" aren't binary. Smokers are skinnier than non-smokers.
- k__ 3y agoAlso, taking nicotine doesn't seem to be bad. Putting smoke in your lungs on the other hand...
- WastingMyTime89 3y agoNicotine is quite bad for your blood pressure.
- 3y ago
- alexfromapex 3y agoTurns out Monsters are pretty healthy for you except for all the sugar.
- euroderf 3y agoBased on a survey of felines, mice are pretty healthy for you too. Consider: a rich source of taurine and with a delectable crunch.
- abeyer 3y agoCan't wait for this diet plan to go on sale
- friend_and_foe 3y agoYup. I used to be a heavy monster drinker, and I quit because that much sugar a day will kill you eventually.Ia drink a cup of coffee every day now, but I do sip an energy drink when I go on a multi hour drive, and I've found the alertness is unmatched by coffee. So I started adding taurine to my coffee, it works almost as well, good mood lift.
- giardini 3y agoIn the study mice were given 1000 mg taurine per kg body weight per day. In comparison a typical taurine supplement for humans is 1000 mg total. IOW they gave the mice a dose of taurine that, proportionally, i'd be unwilling to take.
- rale00 3y agoYou don't directly convert dosage across species like that. The dosage they tested on monkeys was 250mg/kg, and the human equivalent would be less than that.
- A_D_E_P_T 3y agoThe basic formula from mouse to human is (X mg * (3/37)) = human equivalent dose in mg/kg. In this case (1000mg * 3/37)) comes out to 81mg/kg. So, if you weigh 80kg, it comes out to 6.48 grams per day. That's a lot of taurine, but not really a crazy amount. Easy enough to consume.
- codeflo 3y agoIs there a precise biological explanation for that factor, e.g. metabolism rate or something?
- A_D_E_P_T 3y ago> oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function The equation is from here: https://pubmed.ncbi.nlm.nih.gov/17942826/ https://pubmed.ncbi.nlm.nih.gov/17942826/ For what it's worth, the rat equation is (X mg * (6/37)) Keep in mind that it's a loose/general guideline. Basically a starting point. But usually a quite accurate one.
- hooo 3y agoWhen my son had cancer, many of the medication dosages were based on body surface area. Maybe it is similar to that. https://reference.medscape.com/calculator/692/body-surface-area-based-dosing https://reference.medscape.com/calculator/692/body-surface-a...
- mwigdahl 3y ago...in mice.
- canucker2016 3y ago... and female rhesus monkeys.
- nahsra 3y agoIf you RTFA you will note it specifically calls out the multiple models tested. It also points out that these are evolutionarily conserved pathways, so of course the translatability chances are higher than baseline. To top it off, some of those pathways have already been associated with increased healthspan and lifespan in many other studies. I am interested in informed skepticism, because this is kinda compelling. Disclaimer: I don't really know shit.
- DoreenMichele 3y agoTaurine is an amino acid, aka a building block of protein. It's found in abundance in meat and seafood. (I had trouble parsing the title of this piece. Insert joke here about how I don't need to read this article because I no longer own a car nor have a driver's license.)
- fnordpiglet 3y agoTaurine does not contribute to protein structure. Taurine helps regulate the levels of water and minerals in the blood, contributing to overall fluid balance and proper functioning of the muscles and nerves. Also it acts as a neurotransmitter in the brain. Taurine is found in high amounts in the eye and it's thought to protect against retinal degeneration. Finally Taurine is used in the formation of bile salts. But, unlike most amino acids it’s not used in protein synthesis.
- DoreenMichele 3y agoThank you.
- MrGuts 3y agoYou say "taurine", I say "meow".
- k__ 3y agoThey fed mice 1g taurine per 1kg body weight per day. For me that would be 80g per day. 1kg of pure taurine cost 25€ on Amazon. That makes a 1.20€ per day. Sounds okay.
- ruffrey 3y agoIt would likely be less. See approaches like allometric scaling of dosages.
- k__ 3y agoEven better! I'd expect my blood pressure going through the roof with 80g taurine per day.
- canucker2016 3y agoThey also fed female rhesus monkeys 250mg/kg taurine - 1/4 of the mice dosage. Makes the value-calculations even more palatable (does taurine have flavour?)
- A_D_E_P_T 3y agoAfter scaling, it comes out to 6.5 grams per day. (See my comment above.) DO NOT take 80g taurine in a day. You probably won't die, but it's a terrible idea.
- k__ 3y ago:D I wouldn't. I just evaluated how much it could cost to gain a few years. But thanks!
- HPsquared 3y agoMice have faster metabolism, so eat more of everything per kg of body weight per day. Square-cube law in action!
- fwungy 3y agoIf you take Essential Amino Acids your body will make whichever aminos it needs most. You can target supplement something, but it might not be the most critical link at the moment.
- fasteo 3y agoAny nutrient deficiency is usually a proxy for a poor diet, or at least a diet lacking some key foods. For taurine, it would be some animal food source, specially molusk/fish.
- pfannkuchen 3y agoObviously the real driver of aging is that there was no selective pressure to keep the organism working after sufficient semi-clones were brought online, and keeping an organism functional is a hard problem. The solution is to gain the ability to simulate the organism that results from a particular DNA sequence, understand the design problems in the organism, fix the problems, then alter human DNA to include the fixes. We aren’t going to find a simple fix, sorry everyone.
- seydor 3y agoBut if the organism lived longer it would keep pumping semiclones. And if organisms are basically huge self-sustaining feedback loops, why won't they keep sustaining ... forever until some pressure forces them to decay
- enkid 3y agoThere are trade offs for living longer. For example, children of older fathers are more likely to have birth defects.
- pfannkuchen 3y agoBecause the semi clones are a full process reboot. Rebooting is an easier way to solve the problem of continuing to exist into the future.
- K0balt 3y agoSexual reproduction, which increases fitness? So theoretically the offspring are more fit clone producers so competing with them is bad, M’kay?
- seydor 3y agoBut who invented fitness? Theoretically a self-sustaining chemical reaction can go on forever, and it is energetically less costly to search ways to sustain it even further rather than rebooting the whole organism from start. The invention of death must have happened before the beginning of evolution. Which reminds me that our quest for immortality is the end of it.
- bluedays 3y agoGot it. So I need to eat more cat food.
- cjohnson318 3y agoI'm confused. Taurine is found in meat, fish, and apparently, RedBull. But I thought there was a negative correlation between health/aging and eating lots of meat and RedBull. Is there a secret source of taurine that I'm missing? If I double up on fish, can I expect to live longer, assuming I don't accidentally increase my mercury levels?
- jstarfish 3y agoEnergy drinks aren't a good source-- there's lots of Taurine, sure, but the net effect of the drink acts as a diuretic. Chronic dehydration will subtract from life expectancy.
- justinbstrong 3y agoWhat if you drink water with it?
- canucker2016 3y agothe wikipedia entry for taurine states that the human body can synthesize taurine from cysteine as well. the wikipedia entry also says dietary taurine intake is rather low, considering the doses the main article talks about, about 40-400mg/day taurine intake. see https://en.wikipedia.org/wiki/Taurine https://en.wikipedia.org/wiki/Taurine
- nradov 3y agoNo one has ever proven a direct causal relationship between (unprocessed) red meat consumption and poor health. The studies which purport to show a link are all low quality observational studies that suffer from the healthy subject effect and failed to control for some confounders. If there is a real effect it is very small, much less significant than total calorie intake.
- chaxor 3y agoPerhaps another example of us not really having a clue what's going on with biology, and how it's especially bad when this intersects with anything related with diet. Biology of aging is already extremely difficult, and that's just when we can try for separation of variables in studies of organisms such as yeast. Moving to mammals causes incredible challenges in determining molecular biology drivers, and trying for small molecules interventions beyond that typically causes far too much to be lost in translation. Diet just takes it a bit further by mixing a huge concoction of small molecules together and calls by a simple name, like 'egg'. So all in all, if you want to learn what's really going on, try learning the planarian or yeast cell biology literature first before moving on to these more complex systems in order to get a decent idea for how much weight they hold.
- ppeetteerr 3y agoI'm surprised to see no mention of exercise in the comment section. It seems that working out produces "[...] increased the concentrations of taurine metabolites in blood, which might partially underlie the antiaging effects of exercise." For the able-bodied, it may be enough to incorporate more exercise into our life?
- devmor 3y agoIf you are working out a lot, you might want to consume more taurine anyways (which you can naturally get from eggs and meat). It's an important amino acid that supports muscle growth. I believe it plays a factor in getting salts/electrolytes to the tissue, but I'm not 100% clear on that.
- throwaway2368 3y ago[dead]
- nikolay 3y agoMagnesium taurate is a must for just everybody!
- udkl 3y ago~post deleted for privacy~ I will report back on the experiment, however.
- seoulbran 3y agoYou're a nice person. Thanks for the post.
- bilsbie 3y agoMake sure to report back
- crtified 3y agoBe sure to rule out the 'sugar rush' effect. Not that your ~150 millilitre (or just over 5 fl oz) drink is the world's worst in that respect - it weighs in at around 4 teaspoons of sugar, based upon my googling. Some energy drinks have more. It's still the sugar equivalent of having a small cup of tea/coffee/water, and stirring in 4 sugars. If chugged down quickly, that's quite a hit! Even if not, it's still more sugar rich than most things you'll intake in your day-to-day. Your experience may well be due in part or whole to taurine, I can't say. But parents of young children everywhere can attest to the effect of one overly sugary serving resulting in quite a bit of resultant hyperactivity and mood change over the following hours. So your experiments may benefit from some controls in that respect.
- udkl 3y agoIt was a sugar-free monster. Drinking or eating other sugar rich products do not have the effect.
- crtified 3y agoThat's great, then. It seems like, depending on how knowledge develops, taurine may become quite the popular product. As a person in a not-dissimilar situation - thanks a lot for posting.
- LouisSayers 3y ago
- pedalpete 3y agoI'd be curious to know why taurine in blood declines with age? Though supplementation is fine, if the diet stays the same, what is happening in the body that makes it unable use the taurine which is naturally in food. Also, apparently only animal products contain taurine, and vegans have lower levels of taurine. https://veganhealth.org/protein/taurine-and-carnitine/ https://veganhealth.org/protein/taurine-and-carnitine/
- robwwilliams 3y agoI am not sure this is true in all strains of mice. Remember these are data generated from a single fully inbred strain of mouse. I am checking now fir s set of 40 strains we have studied to get a better sense of the decline.
- nradov 3y agoIn general the digestive system becomes less effective at extracting all amino acids as we age. This is why elderly people need to increase their protein intake in order to avoid sarcopenia.
- pedalpete 3y agoThat's interesting. Looks like I'll be spending part of my day looking at how our gut changes with age. Thanks!
- robwwilliams 3y agoSolid study, but the core results are based on a single genotype of mouse — C57BL/6J. Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice? Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence variants). My hope is that taurine supplementation would work just as well using 120 UM-HET3 mice. A robust finding like that would impress me so much more. I wish high profile journals—Science and Nature and Cell—would demand that submissions include at least several genotypes of mice. N = 1 studies are just barely worth discussing in HN with respect to humans. In this case the authors did extend to other models to support their claims but these supplementary components do not test longevity directly. Having pointed out the downside of this work, I am glad to see this study and will treat it as a promising pilot. Given much previous work my guess, and tacitly, those of the authors, is that taurine supplementation will be beneficial for many genotypes of mice and even humans. However, there will not be one optimal treatment regimen for all mice or for all humans. By the way: A 16 oz can of Monster contains 2 grams of taurine.
- tiffanyg 3y ago> By the way: A 16 oz can of Monster contains 2 grams of taurine. And at least 50%+ of the "added sugar" recommendation(s) for an entire day (depending on whether you look at FDA, AHA, etc. guidelines). You make good points, for sure, and I appreciate your comment and insights. But, "sugar" is definitely an issue with a lot of current foods. Carbohydrates are crucial building blocks, biochemically. However, there are numerous increasingly documented adverse effects stemming from "simple sugars" consumption - both epidemiologically, and mechanistically / molecularly (e.g., "glycation"). That said, I'd absolutely recommend sugar over many other available sweeteners. In fact, there are a whole host of "refined" food "modifiers" increasingly available and used that seem to have often unfortunately deleterious effects. For example, even substances like inulin, sugar alcohols, etc., that can be beneficial (have been determined to contribute to healthfulness) in various foods that have been eaten by humans for centuries if not millennia, often end up either not beneficial or actually harmful as applied in current "modern food chemistry". This isn't to say that we must go "paleo", nor that there are inherent or unsurpassable problems in formulating and "manufacturing" (always a word I love, when it comes to food ... meh) new food products that are safe and have advantages over many entirely unprocessed foods (hell, cooking IS a form of processing, and it's rather crucial given our physiologies, improving safety and nutrition of many types of foods significantly). But, food processing and manufacturing is a rather lightly regulated industry in some ways, and much of it moves far faster than studies of the implications of all of the new formulations, additives, etc. Time and again, people and industry have been enamored of some apparent "free lunch" that has bitten us in the ass, so to speak, ultimately.
- carrja99 3y agoSo drink lots of Red Bull eh??
- lo_zamoyski 3y agoIt's the other garbage in the drink that'll do you in!
- myth_drannon 3y agoFunny, just yesterday was watching a video of wild foxes animal shelter and they were feeding raw eggs to them. Talking about importance of Taurine - https://youtu.be/z8W0LSarQ8s https://youtu.be/z8W0LSarQ8s
- lr4444lr 3y agoDoesn't amino acid uptake generally decrease with aging, leading to sarcopenia/osteopenia? Doesn't exercise generally improve amino acid metabolism? Why focus on taurine?
- objektif 3y agoWould taking supplements work as well? I saw that Taurine supplements are available for cheap. I have no idea what people are taking it for.
- salad-tycoon 3y agoHeart health/CHF, physical performance, mood ( seems to “even out” effects from caffeine), liver function/hepatitis.
- andy_ppp 3y agoI order stuff off the Internet from time to time including taurine, is there an easy/cheap way to test things that come through the post from Amazon or another company are Taurine and don’t contain things they shouldn’t? The supplement industry strikes me as dubious! Is there a better way to think about this?
- devmor 3y agoOrder from a trusted pharmacy, rather than from 3rd parties like Amazon. With the way binning works at Amazon, you can't trust that you will get a legitimate product even if you ordered the same thing you made sure was legitimate last time.
- miked85 3y agoYou may be correct, but I doubt there is a high enough profit for such a cheap supplement to be counterfeited and sold 3rd party.
- colechristensen 3y agoMaybe just drink Red Bull. Supplements are dubious, buying things on Amazon you consume is especially dubious. There are some signals here and there about the legitimacy of various vendors but I’m generally skeptical of all of them, just some more than others.
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- nradov 3y agoLook for supplements with the NSF Certified for Sport mark. Order direct from the manufacturer instead of Amazon which is full of counterfeit products. https://www.nsfsport.com/ https://www.nsfsport.com/
- salad-tycoon 3y agoI’ve been considering the same. I think, first off, Amazon is absolutely the worst place to buy supplements due to potential fakes. I’ve seen consumer labs.com has done some independent 3rd party testing but it’s not on everything. There are nootropic outfits that will send you the COA on request. Obviously, who knows what that piece of paper is worth. They could have bought a clean report or could have done a bait and switch. For my part I research user reviews before I buy something . If a company has been caught lying in the past, I avoid them. No affiliation, I’ve found nootropics depot and lift mode to be well regarded in the Ethernet, generally.Also, Thorne, cellcor, life extension. But again this doesn’t solve the problem of trust. Strangely a lot of internet denizens have a loyalty of their suppliers and typically users report just on what they perceive to be effects and physical properties of supplements received. I also give some weight to anabolic steroid forums. Think what you want about them but the meatheads are real citizen scientists in the realm of chemical ingestion and prone to distrust (and astroturfing on the flip side). I think some of the smaller companies just buy things off of places like Ali baba. Larger companies still source a ton of their stuff from China. The better smaller companies make an attempt to be transparent with COA, the larger ones just work off their name recognition. This lack of trust of Chinese consumables extends far beyond just supplements and even the honey industry is implicated in fake products. Recall chinas baby formula fiasco a while back or that they made aquadots out of GHB or the toxic paint they use on toys. Etc. Plenty of reasons for distrust of drop shipped or sourcing from overseas/China. It’s the Wild West out there in the supplement world and even worse in the “research chemical” peptide world. I wish we could have a crowd sourced funding for 3rd party testing.
- ggm 3y agoIf you're old, Eat more protein. Anyone doing any degree of attempt to recover (lost) muscle tone as an older person is told 'eat more protein' to help "feed" muscle mass rebuilding after the exercise induced stresses which are heading to "bigger muscles" So if you eat more protein, you're going to get Taurine. Drinking a can of "monster" is not the answer. Does this mean "exercise extends life" is actually .. the protein you eat building muscle is supplying the taurine you need to extend life? (no: more muscle is a net good all of its own. it helps with diabetes/insulin issues, it helps with core stability == less accidents. it helps with preventing bone loss. it helps with cardio. but ... )
- chasil 3y agoWould it be more practical to take a supplement containing all the amino acids used by [human] ribosomes? Those, as I understand them to be, are: alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine. And why am I not seeing taurine in this list? https://www.cryst.bbk.ac.uk/education/AminoAcid/the_twenty.html https://www.cryst.bbk.ac.uk/education/AminoAcid/the_twenty.h...
- deleted 3y ago[deleted]
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- raylad 3y agoThis actually may not be good advice, because methionine restriction has been found to mimic caloric restriction in extending lifespan, and also inhibits cancer cell growth. See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008916/ and https://pubmed.ncbi.nlm.nih.gov/32138282/ https://pubmed.ncbi.nlm.nih.gov/32138282/ for example.
- insanitybit 3y ago
- ck2 3y agoNote most protein chains have taurine, like whey. If you are following the 1g per kg per day of protein guideline, you likely have been taking in plenty of taurine and your body makes some too. But general population nutrition basically gets worse every year, people other than athletes are likely not getting enough protein. Food prices now are also going to be a huge problem, protein isn't cheap in any form.
- hknmtt 3y ago[flagged]
- janmo 3y agoDid Red Bull sponsor this research paper?
- gigatexal 3y agoYou mean that stuff in redbull ;-)
- rjtc 3y agoNot good news for vegans looks like, as top sources of taurine are meat?
- dsign 3y agoAs a PhD and a hobby writer myself, I tend to put a lot of attention on first sentences. And it is something that all academics do, specially when submitting to the highest divinities, i.e. Science and Nature. The first sentence in the structured abstract of this paper is curious: > Aging is an inevitable multifactorial process. If the paper were discussing aging in general, the use of the word "inevitable" would be an expected adjective. Not entirely useful, it wouldn't be new information because everybody knows that aging is inevitable, but excusable. Yet, the paper is discussing counteracting--if only a little--aging. I would have written "Aging is a poorly understood multifactorial process" (to be modest), or "Aging is the combination of natural drift and degradation in complex systems and evolved coping mechanisms" (to set the world on fire). So, to me, this first sentence sounds like cultural subservience: "Before you get the pitchforks and the bonfires, we don't want to be young forever, please spare us. Now, with that out of the way, aging is a multifactorial..."
- heresie-dabord 3y ago> cultural subservience Or perhaps recognition that we live in the time of a Fallacy-Industrial Complex? "Aging is inevitable, there is no magic, don't delude yourself into thinking that you are going to avoid aging by gorging on some single element or compound. Get enough rest, take care of your teeth and gums, exercise daily, and maintain a healthy weight. Everything else is a marketing scam. That said, here's what we found playing with mice and taurine..."
- wly_cdgr 3y agoAlcohol abuse riding shotgun for a lot of y'all tho
- shipmaker 3y agoso this explains why vegans look older
- amai 3y agoSo people on a vegan diet ( low in taurine ) will live shorter?
- amai 3y ago„However, prolonged intake of a vegan diet with negligible taurine content leads to a decline of only ∼20% in circulating taurine in young healthy individuals (6, 7), suggesting that the ∼80% decrease observed in older people by Singh et al. at least partly reflects a loss of capacity for endogenous synthesis“ See https://www.science.org/doi/10.1126/science.adi3025 https://www.science.org/doi/10.1126/science.adi3025
- amai 3y agoIsn‘t any deficiency a driver of aging?
- amai 3y agoDon‘t miss out the related perspective article on this: https://www.science.org/doi/10.1126/science.adi3025 https://www.science.org/doi/10.1126/science.adi3025 It discusses important issues like „ A key issue for any longevity intervention is whether it causes calorie restriction (which can extend life span) or acts through independent mechanisms. Singh et al. found that taurine supplementation did not affect food intake in mice but nonetheless caused a small decrease in body weight, indicating a calorie deficit. Energy expenditure was higher in taurine-treated mice and intestinal transit time was accelerated, although it is not clear if nutrient absorption was decreased. The change in intestinal behavior is intriguing, because taurine is conjugated to bile acids to form bile salts, which facilitate uptake of dietary lipids (1). It will be crucial to control for the effects of taurine on body composition and nutrient uptake in future studies.“
- Sloppy 3y agoWow, Red Bull does give you wings!