14 ms·
Mini brains grown from stem cells developed eye-like features (2021)
- andrewstuart 4y agoHook it up to ChatGPT, put it in a Dalek machine.
- LinuxBender 4y agoI like the idea but I think it would be a waste of ChatGPT as most words would be translated to EXTERMINATE.
- bozhark 4y agoDAN mode
- deleted 4y ago[deleted]
- viraptor 4y agoIf it gets a large language model, it can INTERPOLATE.
- armatav 4y agoAh, man made horrors beyond my comprehension, excellent
- xwdv 4y agoI don’t see a problem.
- LegitShady 4y agothats because you've developed eye like features.
- Sakos 4y agoThis is terrifying. I wonder what it'd take for a mini-brain to gain consciousness. https://en.wikipedia.org/wiki/Cerebral_organoid#Ethics https://en.wikipedia.org/wiki/Cerebral_organoid#Ethics
- serf 4y agoa better question is : 'would we know if it did?'
- viraptor 4y agoIf it grows neutrons for connecting to vocal chords, we could...
- Joyfield 4y agoAnd after that we need to figure out why it is constantly screaming.
- slowmovintarget 4y agoFor I Have No Mouth and I Must Scream Boltzmann Brains don't fluctuate into existence, they get created when entropy is moderate enough to produce galaxies with people in them that develop tech for cloning.
- konfusinomicon 4y agoconsciousness then evolves into telepathy..the scientists while hard at work studying these growing cell masses then start hallucinating while in the presence of the mini brains, driving them into insanity.. and next thing you know we've gone full on Akira and the destruction of neo Tokyo is imminent
- datavirtue 4y agoThere has to be a movie from the 1950s covering this.
- baja_blast 4y agoA little conscious being grows eyes to understand the world around it, to later be disposed of after the study is over.
- TedDoesntTalk 4y agoMaybe you are describing us, too.
- tremon 4y agoIt's still better than being paved over for an expressway before the study is over, I guess.
- 31337Logic 4y ago42.
- SentientAtom 4y agoThey were mostly harmless anyway.
- deleted 4y ago[deleted]
- smrtinsert 4y agoPrecisely what I was thinking. Where are the ethical discussions around this occurring? Where are those agreements or resolutions captured? edit: apparently there are no laws banning human cloning!
- TedDoesntTalk 4y agoI doubt they started with human stem cells. More likely mouse.
- 24hourpassion 4y ago[dead]
- knodi123 4y agohttps://knowyourmeme.com/memes/you-may-live-to-see-man-made-horrors-beyond-your-comprehension https://knowyourmeme.com/memes/you-may-live-to-see-man-made-...
- sowbug 4y ago"Instead, iPSCs are taken from adult human cells, usually from a skin or blood sample, and converted into an embryonic-like state." What would happen if the adult human donor took these embryonic-like cells and reinjected them? Would the person develop the vim and vigor of a young adult?
- mjfl 4y agoThey would develop widespread teratomas similar to metastatic cancer, and die. https://en.wikipedia.org/wiki/Teratoma https://en.wikipedia.org/wiki/Teratoma
- debenedictis 4y agoThat teratoma link has quite disturbing pics.
- KRAKRISMOTT 4y agoUnless it is from a biological clone of you (or iPSC) and pre-treated with a chemical cocktail and used under carefully controlled conditions. This isn't the 1960s, we have a much better grasp of molecular biology and human development now. The fields of immunology and regenerative medicine have come a long way.
- coldtea 4y agoWe do have a better grasp, but we're still in the "trying various things blindly and see what sticks" stage and will be for some time...
- sedatk 4y agoIsn't this expected? Synthesizing a fully functional "organoid" from stem cells is profound, but why are eyes more important than the rest of the brain? What's surprising?
- deleted 4y ago[deleted]
- Sakos 4y agoMy take from reading the article is that they were able to make a cerebral organoid develop these eye cups. Until now they were either able to make a brain or the eye. > In previous studies, only pure retinal cells or optic cups were grown in the lab individually. Jay Gopalakrishnan, an organoid expert at University Hospital Düsseldorf, and his colleagues used iPSC-grown mini brains to see if eye structures could develop as an integrated part of the organoid—instead of growing the two parts separately, Science Alert reports.
- sedatk 4y agoThanks, yes, that's definitely a big step then.
- amelius 4y agoWhy a pair of eyes? And not three, four, five, ...?
- colechristensen 4y agoBecause you’re bilaterian which is a very far back feature and basic aspect of embryonic development. You have two of things mirrored left-right.
- mlok 4y agoYour reasoning about bilateral/symmetry implies there is an even number of things (like the 8 eyes spiders have) 2 is not the only even number for this. (Also, I find it interesting that most of internal organs are not symmetrical)
- cgriswald 4y ago> (Also, I find it interesting that most of internal organs are not symmetrical) And they can sometimes grow 'mirrored': https://en.wikipedia.org/wiki/Situs_inversus https://en.wikipedia.org/wiki/Situs_inversus
- colechristensen 4y agoEh, similar answer, your basic body plan goes back really far in your genetic history and is a really early part of embryonic development. All of your relatives going back to a common ancestor ~500Ma have two eyes. It’s a quick internet answer not an essay, the exact correct common ancestor / taxonomy group is a bit difficult to pin down. Bilateria is the reason the number is even… some common ancestor after you split with spiders is the “exactly two” reason, which i think is all vertebrates now, or at least close to that level.
- eternalban 4y ago'External symmetry is an adaption to environment' seems to be a promising starting point. You can see this at the micro level too: cell externals and internals.
- generalizations 4y agohttps://www.sciencedirect.com/science/article/pii/S1934590921002952 https://www.sciencedirect.com/science/article/pii/S193459092...
- locusofself 4y ago[flagged]
- deleted 4y ago[deleted]
- lurquer 4y agoThe concept deals with evolving an eye, not growing one.
- deleted 4y ago[deleted]
- wkearney99 4y agoSo, uh, daleks?
- LarryMullins 4y agoEyes, but no mouth. Unable to scream.
- deleted 4y ago[deleted]
- fnordpiglet 4y agoI, for one, welcome our brain organoid eye cup overlords.
- thevagrant 4y agoAt some point we may end up with a brain(s) used to control the metaverse? Tad Williams Otherland series felt ridiculous toward the end, now I'm not so sure.
- linuxftw 4y agoI don't know about controlling the metaverse, but my personal theory is that AI will be dominated by computer-integrated primate brains, possibly genetically modified.
- djmips 4y agoI honestly still think this is the real plot of the Matrix. They weren't batteries - they were cheap computing resources working in concert to literally create the Matrix.
- zirgs 4y agoApparently that's what they intended originally. They wanted Morpheus to show a CPU instead of a battery to Neo in that scene. But they decided to not do that, because they thought that the audience would not understand what that is.
- 29athrowaway 4y agoIf Elon could use one of those instead of some of those poor pigs or monkeys for Neuralink it would be great.
- Joyfield 4y agoOr use it to run Twitter successfully.
- foobarbecue 4y agoThis is especially cool because I just watched I Origins for the first time. (I really liked it. Steel yourself for one very gruesome scene)
- Kiboneu 4y agoLight provides predictive power to an organism. That is, light can provide information about action at a distance, of relevance to the future, if there is a brain to process it. Neurons connect and disconnect via hebbian and anti-hebbian processes in response to the stimulus, so in a way the impact of light energy is structured within a biological substrate.
- fexecve 4y agoHaving graduated from high school, this isn't surprising to me. Why would it be? So I'm left to wonder what's going on with this story. Either Smithsonian magazine is read by people to whom basic biology is a mystery, or the editors think that's the case. Or, perhaps Smithsonian magazine is read by people who like this kind of gory horror porn (or the editors think that's the case).