9 ms·
Combination of Rapamycin and Acarbose significantly Extends Lifespan
- deleted 4y ago[deleted]
- olliej 4y agoPlease add the expected [in mice] mysteriously missing from the headline itself
- eruleman 4y agoProps to the authors for choosing the subheader: "This effect was shown in mice."
- ahazred8ta 4y agodose: mice were fed a diet containing 14 ppm rapamycin (mTOR antibiotic) and 1000 ppm acarbose (diabetes drug) for three months
- snvzz 4y agoIf you hate aging (who doesn't), SENS Foundation[0] is dedicated to engineering solutions to reverse it. 0. https://www.sens.org/ https://www.sens.org/
- xcambar 4y ago
- xiphias2 4y agoPeople in SENS kicked out Aubrey de Gray for a ,,grooming” email and took over control of the donations that were sent because of him. I do not condone his previous action, but I also think that kicking him out to take over millions of dollars was not an unselfish action. He is in the process of setting up a new foundation where I expect most of the new donations will flow.
- snvzz 4y agoThere was some drama[0], but did they really[1]? I guess there's his twitter account[2]. Wow. 0. https://en.wikipedia.org/wiki/Aubrey_de_Grey#Sexual_harassment_allegations https://en.wikipedia.org/wiki/Aubrey_de_Grey#Sexual_harassme... 1. https://www.sens.org/about-us/leadership/ https://www.sens.org/about-us/leadership/ 2. https://twitter.com/aubreydegrey https://twitter.com/aubreydegrey
- ck2 4y agoThey've been studying Acarbose for awhile now https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789153/ The problem with a lot of these longevity approaches is they "solve the problem" by reducing energy conversion, like acarbose, pulling people to a baseline and preventing stress adaptations. Great for sitting around. The opposite of that for doing anything athletic, you'd never improve.
- thebeastie 4y agoWhat does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?
- nradov 4y agoRight. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.
- eternityforest 4y agoIs it strong enough to actually cause that, or is it the kind of thing nonathletes won't notice? Or is the life extension effect too subtle to be relevant at all outside a flat mousecage?
- nradov 4y agoIt's just a general trend. The strength of the catabolic effect will depend on the specific intervention and dose. The risk is greatest for non-athletes because they tend to be weaker to start with and more likely to experience disabling falls as they age.
- elevaet 4y agoThat is really interesting. I hadn't heard that, but it makes a lot of sense.
- hericium 4y agoPrevious links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention, longevity: popular in Silicon Valley[5] [1] https://news.ycombinator.com/item?id=32660669 https://news.ycombinator.com/item?id=32660669 [2] https://news.ycombinator.com/item?id=33058322 https://news.ycombinator.com/item?id=33058322 [3] https://news.ycombinator.com/item?id=32648886 https://news.ycombinator.com/item?id=32648886 [4] https://news.ycombinator.com/item?id=27486841 https://news.ycombinator.com/item?id=27486841 [5] https://news.ycombinator.com/item?id=19472942 https://news.ycombinator.com/item?id=19472942
- ChrisGranger 4y agoMy understanding is that Metformin's mortality reduction effect is only present in younger people. I don't have a source handy, but I take it for diabetes and was reading about its other positive effects a few years ago. Perhaps someone can chime in with additional information.
- graderjs 4y agoI'm interested in how ultra-low-dose (or "sparse" regimens) affect things (before you get triggered by homeopathy, I'm not making regard to that here..tho doesn't mean in some cases it can't be effective). For example, ultra low dose minoxidil (a blood pressure drug) reverses hair loss in many people (not if you're totally bald, but in thinning areas) at dosages where it's "on-label" effect (lowering blood pressure) doesn't even occur. I wonder how ultra-low-dose (or sparse, like "1 timer per quarter") metformin affects things. I can't recall the compound now, but I recall seeing something the other day about: "encounter with compound X just one time permanently strengthens immune system" or something. I think it was also in mice. I'm not even sure it was "immune system". Also want to note that: our current pharmaceutical industry of (mostly) single molecule therapies is just one slice of the pie. In the future, we will probably have access to therapies that seem really sophisticated: not just "concoctions" (of multiple compounds in one therapy, which currently we are not sophisticated enough to explore sufficiently so the space of possible interactions that are therapeutic remains unknown); but also more "active" therapies, that include some vector (like virus, protein molecular machine, funghi, bacteria) that help to deliver / manufacture the therapy to just the right: time, location, amount our body needs. And rather than being a specialized minority, they will be the majority. I think the space of molecules that are effective when delivered "systemically" is not as large or contains as many "silver bullet therapies" as the space of therapies that is effective when delivered precisely.
- givemeethekeys 4y agoSomeone should inform the lab mice that they'll be living longer than before.
- revolvingocelot 4y agoI don't think we should burden them in that way. It's hard enough being a lab mouse as it is.
- el_nahual 4y agoLike the joke says, if you're a mouse and still have cancer, diabetes, or Alzheimer's, you need a new agent.
- sitkack 4y agoI am currently undergoing gene therapy to turn into a mouse. All my problems are solved.
- realkiddredd 4y agoTotally misleading headline
- sciencemajor 4y agoRapamycin is a potent immunosuppressor... yikes.
- Blammar 4y agoGuess we'll figure out how to make mice immortal sometime soon, and sadly realize that the drug cocktail doesn't work on humans. Then the meek mice take over the earth as humanity dies off...
- Reason077 4y agoPresumably the mice would still need humans to keep producing the drugs that keep them immortal. But if immortality was a genetic trait passed on to their offspring then we’d be in trouble!
- kiawe_fire 4y agoThis future is oddly more comforting to me than Skynet.
- criddell 4y agoAnd dogs too! https://dogagingproject.org/ https://dogagingproject.org/
- deleted 4y ago[deleted]
- seydor 4y agoIs there progress in the research to transition from human to mouse?
- deleted 4y ago[deleted]
- deleted 4y ago[deleted]
- melonrusk 4y agohttps://archive.ph/Uaeza https://archive.ph/Uaeza
- elromulous 4y agoI think at this point not putting "in mice" in an article title like this is just dishonesty.
- iopq 4y agoI just went straight to the comments looking for "in mice", not disappointed
- slazaro 4y agoI "yelled" IN MICE right after reading the title, went to check the article, and sure enough... But yeah, it seems 100% deliberate because most people wouldn't probably care after reading the title. It's academic clickbait techniques.
- adrian_b 4y agoTo be fair, there is little choice for any such study to be done on anything else but mice, because of their short natural lifespan. Even if there were human volunteers willing to test on themselves various cocktails of chemicals, such a study would take many centuries. Also on monkeys any study would take much too long. So until aging in mice is well understood, any tests on monkeys or humans are pointless. It is unlikely that the aging mechanisms differ in an essential way between mice and humans. If the aging in mice were understood, finding how it functions in humans would need far less work than for discovering how it functions in mice.
- Eddy_Viscosity2 4y agoThe problem wasn't that the study was done on mice, it was that this piece of information out was left out of the title. I agree with the OC that its deliberatively deceptive, unless of course this article was in 'The Journal of Mice' in which case it would be ok.
- JoshTko 4y agoYour last point needs to be emphasized more. The core mechanism of aging is likely to be very similar across species as aging affect all tissues, organs, etc.
- tomohawk 4y agoI get why people are facinated by this sort of research, but pick your favorite nasty person, such as Putin, and consider what it would mean to radically extend their life. People in in Congress (an oxymoron) would be there even longer as they generally have to die to get kicked out. The longer they're there, the less they care about you and the more they'll care about their long lived fellow travelers.
- dsq 4y agoI remember there being a lot of noise a few years ago about resveratrol, and how red wine (but only of a certain grape) was the secret to long life. What happens if you make the wrong decision and go all in, drinking wine and gobbling grape seeds, while it turns about to be something else entirely and you missed the boat? There’s no end to it, especially as there are only two real solutions that work, extreme caloric restriction and young blood transfusions(i.e a personal “blood boy”, humorously depicted in HBO’s Silicon Valley).
- lambdafourtwo 4y agorapamycin triggers the same effect as extreme caloric restriction. Neither of the solutions you mentioned have been scientifically verified in humans. Longevity research itself hasn't been around long enough to verify ANY longevity hypothesis on humans.
- jtbayly 4y ago… in spite of being around for millennia.
- lambdafourtwo 4y agoThe scientific method came around 1600s. Statistics existed in 1662. Science itself has not existed for a millenia.
- jtbayly 4y agoLongevity research has, though. Philosophers stone, fountain of youth, these are the same things we seek today, through new means.
- lambdafourtwo 4y agoDoesn't count as research imo. It's more speculation and musings. Research requires actual science.
- BLKNSLVR 4y agoLow effort post, but, it's almost as if we're working towards this end game: https://youtu.be/y5xcvAoKojo?t=223 https://youtu.be/y5xcvAoKojo?t=223
- Stevvo 4y agoTo me it does look a bit comically like searching for the philosopher's stone as an ancient alchemist. If it's found within your natural lifetime you will be dead before the research is complete; by definition it will take longer than an average human lifespan. Mice only live a year so they are pretty quick and easy to study.
- amelius 4y agoOr become a test subject and get lucky.
- staticassertion 4y ago> If it's found within your natural lifetime you will be dead before the research is complete I'm 30. If it takes another 30 years, I'll be 60. That's late, certainly, but I could still avoid a lot of health issues if I'm able to start taking something then. Most older people I know really start to degrade around their 70s and 80s, often after some sort of health incident or chronic issue crops up. And if not, ok, well then some younger people in a generation or two will benefit and I'm happy for them.
- dominotw 4y agoRapamycin is the word I keep hearing in 'health and wellness' communities online and on podcasts. I think this guy is the most vocal about it https://peterattiamd.com/rapamycin-risks/ https://peterattiamd.com/rapamycin-risks/ https://twitter.com/mkaeberlein/status/1428740546177105922 https://twitter.com/mkaeberlein/status/1428740546177105922
- black_13 4y ago
- hinkley 4y agoI’m very confused. Rapamycin upregulates autophagy, which is a popular theory about strengthening the body by killing the weak cells. Ok. But it’s prescribed as an anti-rejection drug. Those two things don’t dovetail in my mental model.