4 ms·

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluti

Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"

api 5y ago
Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.
- pengaru 5y ago
  My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
  - DoreenMichele 5y ago
    Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
    - SemanticStrengh 5y ago
      And most importantly, sleep and the glymphatic system. There are many substances that promote Autophagy though.
      - DoreenMichele 5y ago
        For the brain, yes. https://news.ycombinator.com/item?id=25427090 https://news.ycombinator.com/item?id=25427090
- deleted 5y ago
  [deleted]
- SemanticStrengh 5y ago
  It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators. BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
  - ErikAugust 5y ago
    Where does one find Skq1?
    - SemanticStrengh 5y ago
      https://mitolab.com/product/vismotech-skq1-bromide-solution-10ml-30ml/ https://mitolab.com/product/vismotech-skq1-bromide-solution-... You should always coadminister (take at the same time or a bit before) NAC (600mg+) SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process. Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect. It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ Google Skq1 on pubmed to see how great it is
  - swader999 5y ago
    Thoughts on fisetin?
- bawolff 5y ago
  I don't understand why dilluting it would work here - either its filterable and it would get filtered regardless (e.g. drinking water would be enough) or it wont be and the dillutant would just be filtered
jasfi 5y ago
So drinking more water would be enough?
- pengaru 5y ago
  This isn't my area of expertise at all. A personal experience that comes to mind is when my childhood cat developed kidney disease. She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
  - three_seagrass 5y ago
    Was the cat checked for diabetes? Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
    - nobody9999 5y ago
      >Was the cat checked for diabetes? >Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them. Those particular symptoms are common (in cats at least) to feline hyperthyroidism, which is significantly more common than feline diabetes. Not saying it wasn't Diabetes, but Hyperthyroidism seems more likely.
      - LargoLasskhyfv 5y ago
        possibly related: https://duckduckgo.com/?q=cats+flame+retardant https://duckduckgo.com/?q=cats+flame+retardant
    - pengaru 5y ago
      Honestly I don't really know what all was checked. We brought her into the vet when she wasn't eating and behaving lethargically, they said her kidneys were failing and we'd have to bring her in regularly for saline bags or learn to administer them ourselves.
candiddevmike 5y ago
All the more reason to donate blood.
- entangledqubit 5y ago
  Now I just need to figure out how to donate brain fluid...
  - aeternum 5y ago
    Brain fluid = spinal fluid, sampling it is a somewhat common procedure, just a larger needle and more uncomfortable.
    - amelius 5y ago
      And I suppose a larger failure and fatality rate (?)
- noneeeed 5y ago
  I believe there are good health reasons to donate. I forget the details, but it stimulates positive processes in the body. I think the effect is marginal, but it's nice to know you get a small personal bonus from doing something nice for other people.
  - throwntoday 5y ago
    I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.
    - allendoerfer 5y ago
      But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.
ninesnines 5y ago
same lab actually!

api 5y ago

Could it be this simple? Shit just builds up in the blood that the liver and kidneys and stuff are not 100% efficient at removing? So you just need to... get rid of it or dilute it? I mean that can't possibly be a full solution but could a major "win" on life span or at least health span be as simple as some kind of dialysis session? Could this also be a hidden mechanism involved in some of that hyperbaric oxygen chamber evidence for life/health extension? Maybe all that oxygen oxidizes and destroys some of this stuff.

pengaru 5y ago
My lay person assumption is it's more complicated than that, just knowing how the body is always conserving resources and adapting to changing conditions. I'd expect the body's natural mechanisms responsible for this to wind down operations the more you intervened on its behalf. It's obviously the right choice in the elderly/ill, but for a healthy young person maybe it's better to exercise/strengthen the body's natural abilities in these departments. I think one of the arguments for intermittent fasting is to clean up the detritus being kept around for energy sake, via natural mechanisms...
- DoreenMichele 5y ago
  Exercise and fasting are two known and proven ways to clean up the tissues of the body, yes.
  - SemanticStrengh 5y ago
    And most importantly, sleep and the glymphatic system. There are many substances that promote Autophagy though.
    - DoreenMichele 5y ago
      For the brain, yes. https://news.ycombinator.com/item?id=25427090 https://news.ycombinator.com/item?id=25427090
deleted 5y ago
[deleted]
SemanticStrengh 5y ago
It is that simple to some extent, recycling and resource control is a major factor in aging. Targets: Autophagy, senolytics (don't take senolytics), lysosomes, metabolic rate, proteasome,chaperone proteins,amyloids,Lipofuscin. The best example of stuff literally accumulating macroscopically in your body (besides the impressive images of Lipofuscin) is metals accumulation in bones. They cause a lot of damage, including a major cause of neurodegeneration. They can be removed via chelators. BTW I would avoid hyperbaric at all cost even if hornesis is a thing. Oxygen is literally the reason we are all slowly dying, we oxidize and implode. But don't refrain from breathing, hypoxia incurs more damage. If you want to prevent oxidation you need Skq1.
- ErikAugust 5y ago
  Where does one find Skq1?
  - SemanticStrengh 5y ago
    https://mitolab.com/product/vismotech-skq1-bromide-solution-10ml-30ml/ https://mitolab.com/product/vismotech-skq1-bromide-solution-... You should always coadminister (take at the same time or a bit before) NAC (600mg+) SkQ1 is a revolutionary geroprotector,it significantly slow down the aging process. Unfortunately it can (proportionately with the dose) reduce mitochondria bioenergetics via a paradoxal, local, pro-oxidation. Studies have found NAC mostly prevent this paradoxal oxidative side effect. It was probably in this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422527/ Google Skq1 on pubmed to see how great it is
- swader999 5y ago
  Thoughts on fisetin?
bawolff 5y ago
I don't understand why dilluting it would work here - either its filterable and it would get filtered regardless (e.g. drinking water would be enough) or it wont be and the dillutant would just be filtered

jasfi 5y ago

So drinking more water would be enough?

pengaru 5y ago
This isn't my area of expertise at all. A personal experience that comes to mind is when my childhood cat developed kidney disease. She drank plenty of water, urinated excessively, and her blood still became toxic without regular (~daily) intervention in the form of adding saline to her blood intravenously. Like a light switch she'd resume normal life after the saline bag emptied into her blood, then slowly become ill again in the next 24-48hrs.
- three_seagrass 5y ago
  Was the cat checked for diabetes? Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them.
  - nobody9999 5y ago
    >Was the cat checked for diabetes? >Excessively drinking water, excessive urination, and renal failure are all co-morbidities for cats. Either way, kudos for helping them. Those particular symptoms are common (in cats at least) to feline hyperthyroidism, which is significantly more common than feline diabetes. Not saying it wasn't Diabetes, but Hyperthyroidism seems more likely.
    - LargoLasskhyfv 5y ago
      possibly related: https://duckduckgo.com/?q=cats+flame+retardant https://duckduckgo.com/?q=cats+flame+retardant
  - pengaru 5y ago
    Honestly I don't really know what all was checked. We brought her into the vet when she wasn't eating and behaving lethargically, they said her kidneys were failing and we'd have to bring her in regularly for saline bags or learn to administer them ourselves.

candiddevmike 5y ago

All the more reason to donate blood.

entangledqubit 5y ago
Now I just need to figure out how to donate brain fluid...
- aeternum 5y ago
  Brain fluid = spinal fluid, sampling it is a somewhat common procedure, just a larger needle and more uncomfortable.
  - amelius 5y ago
    And I suppose a larger failure and fatality rate (?)
noneeeed 5y ago
I believe there are good health reasons to donate. I forget the details, but it stimulates positive processes in the body. I think the effect is marginal, but it's nice to know you get a small personal bonus from doing something nice for other people.
- throwntoday 5y ago
  I've actually been regularly donating for years for that very reason. I figured my body will just create new blood to fill in the gap and much like changing power steering fluid, after enough time it's mostly new stuff.
  - allendoerfer 5y ago
    But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.

ninesnines 5y ago

same lab actually!