6 ms·
What costs are exponentially dropping?
What costs are exponentially dropping? I.E. dropping Solar panels, Body scan medicine, Chip costs. Cell phone tech?
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- superphil0 7y agoGene sequencing
- dekhn 7y agothe price of genome sequencing is no longer dropping exponentially. And when it was, it was heavily amortized across very expensive machines that masked the true costs.
- rfc 7y agoThis. The only current driver of cost reduction in genome sequencing at the moment is subsidization.
- henryaj 7y agoHuh, didn't know this. Surely the cost of the machines has to be included somehow in the cost per basepair?
- dekhn 7y agoLet's just say that every analysis of sequencing costs I've seen has to play extensive trickery with the various costs (the capital cost of acquiring the machine, the operational costs of the reagents, the costs associated with staff running the machine, the servers required to store the data after it's acquired). Basically the stated prices are "the operational costs for a reagent" with the cost of the machine subsidized out or amortized or otherwise hidden from the calculation. Many of the predictions about exponential genomics were done during a period of a few years where those misleading rates were published. I spent a bunch of time trying to figure out how to engineer systems to deal with exabytes of genomics data, but there is no reason to do that, because there isn't that much data being produced/retained or that needs to be maintained on spinning platters of rust. Just another example of bio hype, unfortunately.
- deleted 7y ago[deleted]
- ganzuul 7y agoPrice per megabyte of non-volatile storage, probably.
- situational87 7y agoTech startup valuations, all contracting exponentially. Super cheap! Sorry I'll show myself the door.
- siberianbear 7y agoBack when I was a kid, Silicon Valley startups sold dollar bills for ninety cents. Now WeWork is selling them for a nickel. The cost of everything is dropping like a rock! /s
- marcosdumay 7y agoYou have a biased sample. They follow a curve similar to a normal distribution, but you are looking only at the late stage ones.
- ThrowMeAwayOkay 7y ago"Now is the best time to buy"
- IfOnlyYouKnew 7y agoFood (not the largest exponent, but probably the longest history)
- bryanlarsen 7y agoInteresting fact: the price of a bushel basket of wheat has been approximately equal to a single British Pound Sterling since the 1300s. At that time the pound was only slightly denatured, it was worth only slightly less than a pound of silver.
- guidoism 7y agoI'm not sure. I did some analysis comparing the cost of basic grocery items in the early 20th century to now and they aren't that different. I used the price of gold at the time vs now and the average daily wage to try to get a better feel for relative prices. Over hundreds or thousands of years, yes, definitely. All that said, it seems like automation could push the cost of food to near zero in the coming decades.
- bryanlarsen 7y agoThese guys find that the price of food per hour of unskilled labour wage was about 8 times higher in 1919. https://fee.org/articles/food-prices-in-1919-compared-to-today/ https://fee.org/articles/food-prices-in-1919-compared-to-tod...
- perl4ever 7y agoLooking at this, it seems like in Elizabethan times, a penny was more or less equivalent to a dollar or pound today, if you look at the price of bread, beef, and wine. http://walternelson.com/dr/node/892 http://walternelson.com/dr/node/892 ...however, if you use bread and beef and wine as the standard, then chickens and beer were extremely cheap. But sugar was extremely expensive.
- parenthesis 7y agoYes, it shouldn't be 'breadwinner' any more, but 'rentwinner' or somesuch. People needing to go to food banks is because they have no money left after paying rent, utilities etc., not because food is expensive.
- durgaprasad351 7y agoStock trading
- inform880 7y agoMy 11 year old brother trades stocks Not sure if that's what they meant by free market
- lotsofpulp 7y agoIf he's doing it based on valuation models he's created and 10-Ks, why not. Might be a fun math exercise if he has money to burn.
- TeMPOraL 7y agoHow do you trade stocks with the amounts of money a typical 11 y.o. has?
- mieseratte 7y agoGet a small business loan from your parents? Loads of kids do that for things like a lemonade stand or a lawn mowing business during the summer.
- lotsofpulp 7y agoI'm assuming an 11 year old trading stocks has parents that have money to burn and receives it from them, so this wouldn't apply to typical 11 year olds.
- bryanlarsen 7y agoThere are several brokerages that will let you buy fractional shares.
- RocketSyntax 7y agopenny stocks
- 7y ago
- inform880 7y agoApparently on field DNA testing https://www.nytimes.com/2019/10/27/us/politics/dna-tests-baghdadi.html https://www.nytimes.com/2019/10/27/us/politics/dna-tests-bag...
- aroch 7y agoEhh, not really for any appreciable amount of sequencing, w've been pegged right around ~$1000/human genome for a while now [1]. The machine mentioned in the NYT article is almost certainly a variant of Thermo's RapidHIT system[2], which is not DNA sequencing. [1]: https://www.genome.gov/about-genomics/fact-sheets/DNA-Sequencing-Costs-Data https://www.genome.gov/about-genomics/fact-sheets/DNA-Sequen... [2]: https://assets.thermofisher.com/TFS-Assets/GSD/brochures/rapid-dna-brochure.pdf https://assets.thermofisher.com/TFS-Assets/GSD/brochures/rap...
- deleted 7y ago[deleted]
- amirathi 7y ago-cloud storage -data costs (cell phone, broadband) -hosting (became free in last couple of years thanks to Netlify, GH pages etc.)
- lucb1e 7y ago> -hosting (became free in last couple of years thanks to Netlify, GH pages etc.) Uh, GitHub really wasn't the first to offer free hosting, and it's definitely not something of the "last couple of years". Geocities has been doing that since 1995 and I don't know if they were the first. Moreover, GH Pages is super limited, others allow you to run dynamic scripts (PHP being the most popular). I never heard of Netlify but Wikipedia tells me it's standard shared hosting for static content. As for "cloud" storage, that's getting cheaper in the sense that they are reducing profit margins (getting closer to charging the actual cost price), but if you roll your own, you can still do it for less than what the cheapest third party charges. And those costs are also dropping year over year. With both effects combined, I guess it's dropping quite rapidly, but for two separate reasons and not because of advances in hard drive tech.
- zer0tonin 7y agoNo, netlify is basically a fancy-ish github pages.
- adventured 7y agoThe exponential part is going to trip up most of this. In the best scenarios you might get that for a very short duration of time in a segment and then see a continued, very slow decline in costs. Space launch costs, thanks initially to SpaceX pressure. Wireless and wired broadband access costs per bit continue to decline persistently globally. Satellite broadband costs are about to do a hard one-time plunk as Starlink comes online (another example of the short lived nature of the biggest drops). The cost of entry for a decent virtual reality experience vs the value potential or value derived. The hardware requirements vs the median machine has adjusted massively in the Oculus era and the quality of the software will continue to persistently improve over a long period of time. The cost of lithium-ion batteries $/kWh.
- rossdavidh 7y agoSolar, memory chip, etc. had exponential declines for over half a century, so it's not always "a very short duration of time".
- snaky 7y agoThe cost of computation.
- anton_tarasenko 7y agoThe Wikipedia page on Moore's law includes similar observations.[1] For example, the DNA sequencing cost.[2] And another list that features laws, some of which describe exponential processes.[3] [1] https://en.wikipedia.org/wiki/Moore%27s_law#Other_formulations_and_similar_observations https://en.wikipedia.org/wiki/Moore%27s_law#Other_formulatio... [2] https://en.wikipedia.org/wiki/Carlson_curve https://en.wikipedia.org/wiki/Carlson_curve [3] https://en.wikipedia.org/wiki/List_of_laws#Technology https://en.wikipedia.org/wiki/List_of_laws#Technology
- RocketSyntax 7y agoTo those that say DNA seq; although the cost to perform the actual sequence has dropped, there are still a ton of overhead costs in acquiring and managing any genomic data. Context - product platform guy at biobank.
- rossdavidh 7y agoMy impression is that the cost of the actual sequencing has dropped so much that it is the overhead costs that now dominate.
- aroch 7y agoI mean, I suppose that depends on how you're defining "overhead" cost? To sequence a human genome, you _need_ to purchase a ~$700 reagent kit from Illumina to plop into your HiSeq and a ~$300 library prep kit -- are these overhead? I wouldn't call them overhead, and this fixed-cost hasn't really changed for 5+ years. Those two costs are what makeup the $1000/human genome stat, we don't factor in the human and consumables components
- RocketSyntax 7y agoHow much does it cost you to source that data? What kind of programs are in place to maintain compliance? Who runs the sequencers and performs QC? I'd like to see how those kind of costs stack up against the $0.6K-WGS. Yes, I understand the difference between marginal COGS and opex.
- theandrewbailey 7y agoLighting. https://www.statista.com/chart/10567/the-cost-of-light-through-the-ages/ https://www.statista.com/chart/10567/the-cost-of-light-throu...
- maishsk 7y agoComputer Storage costs
- vishnuharidas 7y agoSolid State Drives.
- jononor 7y agoDon't forget the follow up: Which products/services are now becoming viable or much more attractive as a result?
- huhtenberg 7y agoBarely aged electronic devices, like laptops, phones, TVs, etc.
- wincom 7y agoNostalgic comment: My Commodore Amiga lasted for many years..
- thrower123 7y agoTVs are still getting cheaper, amazingly. I didn't think there was much lower they could go, but $500 buys you more and more TV every years - and that's in nominal dollars, not counting inflation, so the effect is even more pronounced.
- bufferoverflow 7y ago- Costs of delivering mass to orbit. - Nanotubes - Graphene - Internet costs (I'm pretty sure it's dropping faster than exponentially) - CDN and storage in general - Many medical procedures I expect meat prices to collapse in the next 10 years.
- chachan 7y agowhy do you expect meat prices to collapse in the next 10 years?
- jagged-chisel 7y ago> - Internet costs The astute reader will recall these are 'costs' not 'retail prices'
- bufferoverflow 7y agoInternet retail prices have been dropping significantly, except for the places controlled by monopolies. In the EU you can get a gigabit connection for 20-30 eur/month, which seemed impossible even just 10 years ago.
- marcosdumay 7y agoUp to recently, storage costs (GB/$) looked like an parabola in a monolog graph.
- jedberg 7y agoLaptops were for a while, but then stopped once they hit parity with desktops.
- guidoism 7y agoThere's probably some limits to the cheapness. I think hard drives are going to be always at least $35 no matter how small the storage space is just because of the parts and manufacturing. I wonder what those parts are for a laptop.
- gruez 7y ago>once they hit parity with desktops. I don't think they ever hit parity with desktops, mainly due to thermal constraints. There's no way that a 15W laptop cpu can ever come close to a 95W desktop cpu in anything other than short term (< 15s) single threaded performance. comparison between a mid range desktop CPU (i5-9600K) and a high end laptop CPU (i7-8550U): https://cpu.userbenchmark.com/Compare/Intel-Core-i5-9600K-vs-Intel-Core-i7-8550U/4031vsm320742 https://cpu.userbenchmark.com/Compare/Intel-Core-i5-9600K-vs...
- bpfrh 7y agoYou could argue that it reached feature parity. Today you can do nearly everything on laptop including basic editing. Compare that to even 5 years ago where the costs of such a laptop was much higher.
- throwaway_n 7y agoCost per GFLOPS: https://en.wikipedia.org/wiki/FLOPS#Hardware_costs https://en.wikipedia.org/wiki/FLOPS#Hardware_costs Probably the clearest chart that explains why machine learning is blowing up now, despite the fact that the same neural network architectures existed since 1990s (e.g., LeNet-5). It's because cost dropped from $47,000 per GFLOPS to $0.02!!!
- rrss 7y agoThat $0.02 value is entirely bogus. It is based in the published 30 "teraops" for Xavier, which it uses as teraflops and assumes is comparable to the other flops values. ($699/30 "TFLOPS" = $0.02 $/"GFLOP"). "Teraops" counts int8 performance on the GPU plus the random vision and CNN ASICs in Xavier - it is definitely not equivalent to normal fp32 flops. It looks like the GPU in Xavier can do 1.4 TFLOPS single precision, so the correct value is $0.49.
- deleted 7y ago[deleted]
- jerome-jh 7y agoInterest rates since 1980? https://www.macrotrends.net/2016/10-year-treasury-bond-rate-yield-chart https://www.macrotrends.net/2016/10-year-treasury-bond-rate-...
- jbob2000 7y agoAir travel. Depending on the route, it's down to about $1.30 per minute of flight time.
- t0mbstone 7y agoTelevision screens. I bought a 65 inch 4K Sony Bravia tv about 4 years ago for around $2500-$3000. I would be lucky to sell it on craiglist now for $500.