rfc

10 ms·

1.
by rfc 2y ago
Nice! This is really cool. Well done.
2.
by rfc 2y ago
Very cool... nice work.
3.
by rfc 7y ago
Your germ line genome rarely changes. Your exome changes all the time. Your gut biome changes all the time. There's massive market opportunity but a ton of regulations around how to tap into that market opportunity. On a separate note,
4.
by rfc 7y ago
1) You have your own selection bias as we all do. I'm not ignorant to that. However, many of the folks that have gone through similar transformations don't come from "easy" backgrounds. They had their own tragedies (fina
5.
by rfc 7y ago
Alright, I'll bite. This is such a victimhood mentality and a ridiculous statement. I wasn't wealthy when I started investing. Hell, the first dollar I put into my long term portfolio was when I was living in my car! I started wit
6.
by rfc 7y ago
This. The only current driver of cost reduction in genome sequencing at the moment is subsidization.
7.
by rfc 7y ago
My only hope is that we can extend this to biotech as well. The amount of IP theft and insane Chinese government subsidization of biotech that USA-based companies live off of is disturbing. They are so addicted to BS money and are so entren
8.
by rfc 7y ago
Modular housing that grows with your life. Biggest problem there is effective expansion joints that would hold the houses together. Affordable container ship that is electric. A personal finance software that solves upper-middle class issue
9.
by rfc 7y ago
The ones I'm most familiar with are: Acxiom, Datalogix, DataSift, Equifax, Full Contact, and Experian. There's always Twitter as well but they are mostly abstracted data and you can't just waltz in and get their firehose. Mos
10.
by rfc 7y ago
What sucks is that I get the reason why the researchers don't care or gloss over it. It's why I initially got into the space: there's something magical about working on massive data sets and unlocking possibilities with it. I
11.
by rfc 7y ago
Yep! I was shocked when I got the data packet. I had no idea that I could get that much data on individuals. Some other notes about the data: you can get additional hydrations 2-4x/yr @ $50k per pull. The data can be passed via API but
12.
by rfc 7y ago
The White House also evaluated personalization technology to use on whitehouse.gov so that they could serve particular "stats" during major events (election season, SOTU, etc.).
13.
by rfc 7y ago
I took up issue with "Great Hack" as well. At some of my previous companies, we evaluated purchasing data from a lot of these vendors for a data hydration purposes, Cambridge Analytica included. They didn't offer to sell but
14.
by rfc 8y ago
I was going to use a throwaway but f-it. You, sir, are literally 100% correct. My day job is working for a company that competes with Jira. There is a huge trend in the enterprise space to replace their PPM tools with something that is &quo
15.
by rfc 8y ago
This is our biggest gripe with the service. We have a lot of consumers that ask us to perform gene sequencing for them expecting to get something similar to 23andMe. It's always a hurdle to explain the difference between what we do (ta
16.
by rfc 8y ago
Echo this. We have collateral, revenue, decent profit margins, and significant YOY growth (over 500%) and it's been difficult to get a loan or LOC due to how young we are. We finally got one for a small $10k LOC which is funny because
17.
by rfc 8y ago
That's a good point and appreciate the critical feedback. This is the debate we've been having is that we don't want to get close to the "diagnostic" or "insights" world due to regulations. Part of us beli
18.
by rfc 8y ago
It would likely be very similar to our existing service. We send a swab kit, you send back, we group it with other consumers, sequence, then send data back through some encrypted way. We'd likely offer 3 kits out of the gate that are s
19.
Ask HN: Direct-to-consumer genome sequencing
2 points by rfc 8y ago|5 comments
20.
by rfc 8y ago
Have no idea if you've looked at these folks but I hear great things about https://www.flexport.com/ May be worth your time in reaching out.
21.
by rfc 8y ago
Run a genome sequencing facility. Here's what we're looking to do or what is top of mind for us in 2019: Sign a couple of departments that we do a lot of business with onto a sequencing subscription service (recurring rev). Launch
22.
by rfc 8y ago
Couple things: 1) We're services/project oriented. So for each $1 we spend, we receive ~$20 back on revenue. That unfortunately doesn't compound and isn't recurring in the normal SaaS sense. 2) That's $20:$1 on reve
23.
by rfc 8y ago
We switched from Mailchimp to Sendgrid; not hard to switch back. We were hoping to get to a more robust tool but can make do with the basics for now. Also, I wouldn't value my time at $60/hr right now. When you're barely payi
24.
by rfc 8y ago
Seems excessive on the surface but over the course of a year, that's $60. Still pedantic? Sure, but $60 in adspend for us generates $1200 in revenue. As a bootstrapped company, every dime matters to us. Why sacrifice that when there ar
25.
by rfc 8y ago
We signed up with them 2 months ago. As a small but rapidly growing company, we have to keep a close eye on our costs. We'll be cancelling our service with them today because of the price hike.
26.
by rfc 8y ago
Good catch on the error rates. Didn't see that. We go up against universities all the time in our competitive deals. They're generally always cheaper since everything is subsidized however the turnaround times are usually signific
27.
by rfc 8y ago
They don't have their own labs based on how they phrased it within their About Us section. Given that + the turnaround time I'm seeing on the web, I'm willing to bet they outsource this to universities who have sequencer down
28.
by rfc 8y ago
Yeah... it unfortunately doesn't work like that. Illumina is notorious for glossing over many of the finer points around how they get to the fictitious numbers they claim. What they don't point out are all of the reagents, prep ki
29.
by rfc 8y ago
Thanks! We're working on scaling up to human WGS but it will take time. We do have some ideas on how to reduce the price a ton but it requires more capital than we have currently - so either patience or VC. So for now we're sticki
30.
by rfc 8y ago
Initial investment was about $175k, plus some ongoing for various purchases equipment/larger purchases. This is all bootstrapped with no outside investment. Background for myself is in product management for analytics & ML applicat

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