vibrio

25 ms·

301.
by vibrio 8y ago
This makes me happy. Carl Woese has been one of my scientific heroes for decades. The magnitude of his contributions have been very much under appreciated. On top of that, David Quammen is one of my favorite science/nature writers. I a
302.
by vibrio 8y ago
Michael Crichton/Outbreak type stuff isn't what scares me. It is going into a hospital for a routine hernia surgery or dental surgery and getting an infection that responds to nothing. It could happen right now, but is unlikely. T
303.
by vibrio 8y ago
100% this, for sure. you don't have to sell me I'm a microbiologist-- my username here is a tribute to a bacterial genus that drives cholera, necrotizing fasciitis and other nasty stuff. We need new antibiotics now, and it is an e
304.
by vibrio 8y ago
"waste of money" is strong. Live with a loved one as they progress through rounds of cancer therapies and I suspect you will identify unmet need. It will change you. It's not a cancer vs infectious disease/clean water s
305.
by vibrio 8y ago
I very much agree that live stock antibiotic use is a major issue, even with the recent regulatory advances, but I cannot agree that minimizing human misuse is trivial. Ignoring either issue leaves a flank wide open for attack.
306.
by vibrio 8y ago
...that and we'd better start inventing some new antibiotics now. As it is now, physicans can barely prescribe them responsibly. If they are available as cold medicine antibiotic resistance will surge even harder than it is now. antibi
307.
by vibrio 8y ago
while I like to be optimistic about human nature, the ability to find people that don't have political and/or financial interests involved in those decisions is not trivial. The 7.4 Billon people number is irrelevant. No one is g
308.
by vibrio 8y ago
Yes, this. FYI: Charity Navigator gives the David Sheldrick trust a great (4of4 Stars) rating. Alas, the IAPF receives too little revenue to be rated, but is clearly a great organization and cause.
309.
by vibrio 8y ago
Pardon, I have a weak ability to detect sarcasm before finishing my first coffee. I fully agree that p-value limits are arbitrary, and what one is examining can greatly impact the interpretation of 'significance' or not. As you im
310.
by vibrio 8y ago
"I could never study medicine to become a doctor. All that rote learning!" Having taught many med students, I say this attitude would have been a good start towards being a great doctor.
311.
by vibrio 8y ago
But very different things are being measured--comparing them this way is very flawed.
312.
by vibrio 8y ago
This finding (fully believing it is at best anecdotal and preliminary at this point) brought TTF "tumor treating fields" therapy to mind. In the last year or so a medical device was approved by the FDA to treat brain tumors (Optu
313.
by vibrio 9y ago
One should consider any survivorship bias in thinking about that. Also consider that a series A in biopharma is commonly well above above $30MM, and that doesn't generally even come close to funding proof-of-concpet clinical studies. T
314.
by vibrio 9y ago
"The Laffer Curve is a real thing." there are some assumptions about where on that curve we are. The balance sheets of most of these companies were at record levels before the tax cuts, and most of the tax benefits will go into sh
315.
by vibrio 9y ago
People with a mortgage in expensive markets California, Massachusetts, New York...
316.
by vibrio 9y ago
wow I'd have guess that was untouchable. Now I'm going to have to try it. Since ShakeShack appeared in Penn station, that and a tall beer or two has been my post-work Acela fare.
317.
by vibrio 9y ago
This is cool for sure, but that is a large bolus of reading to do. Maybe this is an obvious insight for his community, but the bottleneck in greater biology/medicine is quickly moving from data generation to data analysis (I guess wher
318.
by vibrio 9y ago
The resources and money that was wasted on some of those studies is tragic, and it was facilitated by an attitude in both industry and academia that the few scientists throwing rocks at the amyloid hypothesis were wing nuts. Tragic, and the
319.
by vibrio 9y ago
I agree that pubic funding is an essential foundation for this industry, but disagree that the risk drops before industry gets a hold of technology. Large clinical studies are crazy expensive for many good and many bad reasons, and many of
320.
by vibrio 9y ago
More then last 2 than the first one. Getting money from investors is much harder than getting MAbs from animals. Probably more gruesome, too. Also greed is not just the Pharma. Some Hospitals/physicians use Clinical Trials as a prof
321.
by vibrio 9y ago
T cells kill infected cells by detecting foreign proteins using a lock and key tube mechanism (Key = foreign antigen, Lock = T cell receptor). Normally any given T cell an its off spring have only one specificity of lock (although collectiv
322.
by vibrio 9y ago
...and raining diamonds on Saturn and Jupiter. Surely there is a frothy Series A to be had here somewhere.
323.
by vibrio 9y ago
Please be sparing with its use: Permethrin is extremely toxic to bees. Severe losses may be expected if bees are present at treatment time, or within a day thereafter (7, 12). Permethrin is also toxic to wildlife (9). It should not be appl
324.
by vibrio 9y ago
my view on that is that isopropanol is less discriminate in it's toxicity that hydrogen peroxide. as mentioned above, our cells (but not those of bacterial that live without oxygen) have enzymes such as peroxidase, catalyase, and Super
325.
by vibrio 9y ago
A fair view regarding limiting prolonged usage, especially if the wound remains well vascularized and there is reasonable expectation of immune surveillance. I'm probably less of a germ-o-phobe than 99.9% of folks but deep infections
326.
by vibrio 9y ago
(microbiologist) I agree on keeping it clean and avoiding antibiotics in superficial situations, but I'm surprised by a concern regarding peroxide. Any cut with any depth I have that may have anaerobic potential at all, I use early a
327.
by vibrio 9y ago
I'm not sure 'finite' is the right way to think about it. I'd be more inclined to think of infections acting to 'Exercise' the immune system, similar to how jogging keeps your heart healthy, rather than using
328.
by vibrio 9y ago
also, in considering the macroeconomic impact, one should probably net out the ~7500 employees Walmart laid off the same day they announced the increase wage.
329.
by vibrio 9y ago
each company is different, but your point is largely true. One can look the SEC filings to determine the ACUTAL rates payed by Apple, Nike,etc. There is a reason Nike's swoosh IP is held by a non-operating Ex-US entity in a complex acc
330.
by vibrio 9y ago
which is even more concerning considering reports of how the current resident of 1600 assesses intelligence.

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