vibrio

26 ms·

271.
by vibrio 7y ago
To me the story seems to be The Health Effects of unemployability.
272.
by vibrio 7y ago
Thanks for this, I've been obsessing about track layouts while playing trains with my kid, how to avoid getting stuck in permanent loops, having bi-drectional routes on all parts of the track etc. As I'm not a math person, I&#x27
273.
by vibrio 7y ago
I guess the concern is that paying a company not to challenge the patent(and start the 6 month clock if the patent is lost) is anti-competitive and collusive.
274.
by vibrio 7y ago
for significant small molecule drugs, there is commonly a cohort of generic firms ready at expiry. There is usually little barrier to entry beyond the patent or regulatory exclusivities. Prices are typically crushed after the 6 months. Bi
275.
by vibrio 7y ago
If the patent is invalidated, then what provides the generic company with exclusivity for two years-- I thought the regulatory exclusivity provided to first-in generics was only 6 months?
276.
by vibrio 7y ago
This is nicely stated. There is much wrong with the pharmaceutical industry including pay-to-delay generics, and abusive pricing non-innovative drugs, and that needs too be fixed. Maybe more importantly, effectively communicating the costs
277.
by vibrio 8y ago
First the humans will respond to "$49 tickets from NYC to SF!!", then they will forget.
278.
by vibrio 8y ago
I said in my initial post that it was interesting. I don't think it "invalidates, destroys, or changes completely what we know about viruses". My gripe is with the sensational, click-bait title.
279.
by vibrio 8y ago
Sure, but as far as I'm concerned if you get the byline you own the content. Again I like Yong, not faulting him but rather a general trend in media. I'm being a science curmudgeon.
280.
by vibrio 8y ago
I am also a fan of Yong, but "Upends what we know about virues" is a bit sensational. The article interesting for sure, but lately it seems that every book or study "turns Darwin on his head" or puts us in a "post-P
281.
by vibrio 8y ago
Agreed, but "too popular" within certain geographies, which the structure of the senate favors. If I recall, at least by the numbers a majority in the Senate can be elected by something less than 20% of the US population.
282.
by vibrio 8y ago
According to my basic understanding of basic economics (FWIW), doesn't this put a hole in the monopoly hypothesis here? [I'm not even close to being an economist, but I've taken a basic class or two.] I looked at their 2017 f
283.
by vibrio 8y ago
Are 10-15% margins crazy large in this or comparable sectors? I'm genuinely asking as I'm to busy/lazy to look it.
284.
by vibrio 8y ago
Depends on the stage at diagnosis. If you have localized prostate cancer, I agree with you, you are probably good to go. A few years ago there was a recommmendation by a group of physicians (generally not urologic oncologists) to stop routi
285.
by vibrio 8y ago
most of the interesting data on OV at this point is based on immune stimulation rather than 'oncolytic' activity, thought they are intimately related. They have some of the best combination data with anti-PD1 at this point- some c
286.
by vibrio 8y ago
I'm in your camp and a previous career suffered for being there. I can't bear to count how many massive Phase 3 studies had to fail to raise doubts.
287.
by vibrio 8y ago
> the "amyloid hypothesis" is still the mainstream hypothesis. I agree with you. Amyloid may be the most popular but it isn't what it used to be 10-15 years ago (dogma). it has much weaker support. What is particular true
288.
by vibrio 8y ago
Not at all a Tech/software/hardware guy, but based on my experience with OTA firmware updates with my Netgear router, I'd be cautious.
289.
by vibrio 8y ago
Even if true that the mother was HIV positive, this situation wouldn't justify He's actions for a few reasons. i)They are implanting an embryo in an HIV+ mother, there are other alternatives; ii) For 20 or so years AZT has been us
290.
by vibrio 8y ago
"The most prevalent types of HIV prevalent in Asia are the T-tropic X4 strain " Great comments. There is (at least there was when I followed this more than a decade ago) some data to support that x4 tropic HIV is more aggressive&
291.
by vibrio 8y ago
Most wind instruments require pretty unique tongue actions for 'punctuation' of music. I can speak for the potential for trumpet to be pretty grueling on both lips and tongue for pieces that are rapid, staccato and/or long.
292.
by vibrio 8y ago
When we sit adults down to do low-grade, menial clerical tasks for eight hours a day with minimal breaks, what do we expect?
293.
by vibrio 8y ago
I think you described it pretty well. my version of the same: During their development Lymphocytes have 'gene cassettes' that get shuffled randomly so that the specificity of the receptor (antibody for cells, T cell receptor for
294.
by vibrio 8y ago
Many ways you could a semester of immunology on this. High a level there are molecules called MHC (Major Histocompatability Complex), or HLA (Human Leukocyte Antigen). They are very important to the immune system in a number of ways. Any i
295.
by vibrio 8y ago
By nature, we understand the "what' and "why' of each supercomputer component, as they have been built by us from the bottom up. We are orders of magnitude from understanding each component of the cell. When you get into
296.
by vibrio 8y ago
Does anyone know if C. Elegans get cancer? Not that I'm concerned about the prevention of cancer as a mechanism to prolonging life in this study, but I would consider potential unintended consequences in mucking with these signaling a
297.
by vibrio 8y ago
I don't work around this industry, but it seems to me you are right. I've wondered about the value added by the record labels since the emergence of the internet. It seems that the value of labels used to be production, promotion
298.
by vibrio 8y ago
We did prevent that scenario. The discussion did shift from "having the worlds top military" to "imagine there is no US military". I don't advocate US military disarmament or blind pacifism, but there is some room f
299.
by vibrio 8y ago
Does it? Can that leverage be disentangled from being the largest economy? Economics is a much more effective tool.
300.
by vibrio 8y ago
Bill himself rather flatly told me something along those lines, though I’ve heard various other accounts / opinions. I don’t doubt anyone. Blurred contributions seem inherent to “a-ha” data interpretation moments on science—(as much as

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