> the "amyloid hypothesis" is still the mainstream hypothesis. I agree with you. Amyloid may be the most popular but it isn't what it used to be 10-15 years ago

> the "amyloid hypothesis" is still the mainstream hypothesis. I agree with you. Amyloid may be the most popular but it isn't what it used to be 10-15 years ago (dogma). it has much weaker support. What is particular true and sad about what you've said is that it probably is the most popular but only due to lack of consensus on anything else. After running into the amyloid wall running at full-speed about a dozen times, significant chunks of pharma have nearly abandoned working on the disease, and put some funds into external research.