pfisherman

5 ms·

1.
by pfisherman 6d ago
Being easily verifiable does not elevate something to the level of being a grand challenge. It really drives home the point that biology is not math or coding. I guess to me the grandiosity here feels fake and unearned - like they vibe slo
2.
by pfisherman 6d ago
One mechanism by which the US encourages free market capitalism is requiring reciprocity. China is not evil - they are just self interested - and it is the responsibility of the US government to negotiate a trade agreement that benefits it
3.
by pfisherman 6d ago
Biology already has numerous “Millennium Problems” and the rewards are much more than $1M. For example, reverse Alzheimer’s Disease. Or less ambitious develop high fidelity in vitro and animal models of human disease.
4.
by pfisherman 6d ago
Do US companies have free access to Chinese markets?
5.
by pfisherman 1mo ago
I don’t know. Seems like a distorted sense of justice to me. I am not so sure that academic fraud is in the same league as committing felonies (like E Holmes). Also don’t know that anything beyond professional sanction is deserved for pr
6.
by pfisherman 1mo ago
Many of the comments here in this thread are absolutely vile. Very few people are undeserving of compassion. I think some of the people in this thread should look themselves in the mirror and ask why feel different in this case than simila
7.
by pfisherman 2mo ago
Nice! Thank you for doing this. I am not surprised PCA holds up. It comes with some pretty strong theoretical guarantees. The problem with it has always been scalability. The O(n^3) complexity makes it infeasible to use for massive data
8.
by pfisherman 2mo ago
There are other reasons. One is for career development of your researchers. Another is to be good citizens, in good standing, in the community of scientific researchers. Another is to flex on people and buy class and respectability - to
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by pfisherman 2mo ago
I think land value tax is misguided. Issue is what happens to retirees on a fixed income when value of their property increases? Are they forced from their home to lower priced area? Regardless of how one might feel about the morality of
10.
by pfisherman 2mo ago
My understanding is that an ideally priced IPO should not move much from the opening price in the near term. If it pops it means they left money on the table. If it drops, then I am not sure what the implication is exactly? Now I think Spa
11.
by pfisherman 3mo ago
You could drop the verb clause? This would make the headline accurate while keeping it punchy. > why Americans switch to soy And > why developers switch to codeberg But the cynic in me thinks that the form of the headline that drasti
12.
by pfisherman 3mo ago
Same experience with Fable. Utterly useless for anything bio related. Author of the post here wrote Salmon, which is a widely used bioinformatic tool in molecular biology. And the irony is that Anthropic has probably packaged Salmon as a t
13.
by pfisherman 5mo ago
One quick piece of semantic and linguistic housekeeping for the commenters… Heritable != Molecular / Genetic Mechanism There is a conflation of these terms in popular discourse that does a disservice to the field of statistical genetic
14.
by pfisherman 5mo ago
In some ways domain experience can be a hindrance, with ingrained pathways and practices shaped by constraints that no longer apply. My personal opinion is that you probably want a mix of domain experts who are enthusiastic about AI and so
15.
by pfisherman 5mo ago
I don’t know about this. After some time sitting with it, I think that mid level and senior ICs - especially those slow to adapt - are going to be at risk of getting replaced by entry level “AI native” kids. Net on net it probably washes o
16.
by pfisherman 5mo ago
The comment above is on to something. I find CarPlay to much more valuable and much more of a lock in to the iPhone than Siri. I do not think I could ever go back to using the infotainment systems that ship with cars. So makes sense why t
17.
by pfisherman 5mo ago
No you would not expect all efforts to target AB to work. You can have the right target and the wrong molecule. Look at GLP1s as an example. Multiple pharma companies tried GLP1 receptor agonists for more than a decade and it was not unt
18.
by pfisherman 5mo ago
I don’t quite follow the reasoning behind this being “unbiased”. Studies must be designed to answer specific research question. What is the question being asked by the study in question. If the question being asked is whether AB the right
19.
by pfisherman 6mo ago
Nice work! Here is an article you may find helpful if you have not already come across it.[0]. You may also want to consider benchmarking against some non ML methods.[1] 0. https://pubmed.ncbi.nlm.nih.gov/35318324/ 1.
20.
by pfisherman 6mo ago
This is going to catch some heat, but what if the most important professional “developer skill” to learn or improve is how to effectively use coding agents? I saw something similar in ML when neural nets came around. The whole “stack moar l
21.
by pfisherman 6mo ago
I think Peter Thiel is smart, but exhibiting one of smart people’s most common modes of failure, overestimating one’s ability while not maintaining a healthy sense of skepticism about the correctness of one’s own beliefs. Put simply, he (an
22.
by pfisherman 7mo ago
Yeah, you are not wrong. The topic is a bit like troll bait for me. Probably because I have a first hand view of how the current strain of anti intellectualism and resulting policy in the US is destroying jobs and eroding competitive adva
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by pfisherman 7mo ago
Yes, and they are currently cleaning our clock when it comes to global competition in science and technology.
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by pfisherman 7mo ago
We live in a globalized economy. Rapid transport of people, goods, and information necessitates it. The high paying STEM jobs will go to wherever there is an abundance of talent, and the network effects are quite significant.
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by pfisherman 7mo ago
I associate this phrase with losers and people trying to sabotage the US. You know who is not wringing their hands about “elite overproduction”? China, who are pumping out tons of smart and capable STEM PhDs, and have in a relatively short
26.
by pfisherman 7mo ago
This is very easy to explain. Anthropic outlines some limitations in their terms of service. Palantir accepted those terms. The DoD did not. OpenAI claims their terms of service for DoD contain the same limitations as Anthropics proposed
27.
by pfisherman 7mo ago
Would this actually return memories and context? How could you know if parts or all of it were hallucinated?
28.
by pfisherman 7mo ago
I can see how being able to bring your chats with you would be appealing. But the truth is that context rot is real, context management is everything, and more often than not stating from a blank slate yields the best results. That being s
29.
by pfisherman 7mo ago
Why not use Claude Code from the cli and follow along in your IDE? I did not quite believe when people were telling me or understand what I was missing until I tried it, but after trying that set up I am convinced that it is superior. I d
30.
by pfisherman 7mo ago
Looks like the statistical geneticists have jumped the shark with this one. This big problem here is that their endpoint (chills) is poorly defined, reported by subjects (and thus highly subjective), and not measured using any type of vali

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