pfisherman

6 ms·

31.
by pfisherman 8mo ago
FDA regulates the marketing of drugs and medical devices. This is a case of Hims and Hers (and other compounding pharmacies) marketing drugs without having been granted approval. There is an abbreviated application for new drug approval (A
32.
by pfisherman 8mo ago
Oh boy, are you going to be in for a rude awakening. Might I ask what is your exposure? Because this does not line up with what I am witnessing day to day at all. This type of commentary reminds me of the people during the dot com boom wh
33.
by pfisherman 9mo ago
That is such a bummer. At the time, it was annoying and I groused and grumbled about it; but in hindsight my reviewers pointed me toward some good articles, and I am better for having read them.
34.
by pfisherman 9mo ago
Hotels are not platforms. No network effects at play. The idea of ban is to push teen DAUs below the critical mass necessary for self sustaining retention and growth. Sure teens will still figure out a way to access when they really want t
35.
by pfisherman 9mo ago
I don’t know what this comment is, but it is totally missing and underselling Chinese capability in biotech. They are not coming to push TCM. They are coming to dominate high end drug discovery and development. Perhaps they are looking t
36.
by pfisherman 9mo ago
They are currently eating our biotech lunch. Between cuts to NIH, chaos at FDA and CDC, and China’s intensive investment and buildout of their biomedical infrastructure the US is going to be getting lapped soon. Ask a biotech VC about it.
37.
by pfisherman 9mo ago
Counterpoint: Charlie Brown A big part of what makes Charlie Brown so endearing is his undying earnestness and optimism in the face of near constant bad luck and disappointment. He is exactly the lovable loser archetype that this piece says
38.
by pfisherman 9mo ago
Some biomedical research will definitely run up against guardrails. I have had LLMs refuse queries because they thought I was trying to make a bioweapon or something. For example, modify this transfection protocol to work in primary human
39.
by pfisherman 9mo ago
One thing I have not seen come up in these discussions is how these bans interact with the network effects. They might actually be one of the most effective tools we have to fight back against and punish platform businesses. I assume that
40.
by pfisherman 9mo ago
Thanks for the technical explanation! This is pretty fascinating. So it works kind of like a soft delete — dereference instead of scrubbing the bits. Is this behavior generally explicitly defined in PDF editors (i.e. an intended feature)?
41.
by pfisherman 9mo ago
Can someone spell out how this is possible? Do pdfs store a complete document version history? Do they store diffs in the metadata? Does this happen each time the document is edited?
42.
by pfisherman 9mo ago
Adding to this, the molecular mechanisms of psychiatric disorders such as depression, bipolar disorder, and schizophrenia are not well understood. People prefer their brains and skulls intact so taking brain samples for study is not possib
43.
by pfisherman 10mo ago
I has a Nokia N95. The phone itself was great. The problem was the dearth of apps. Nobody developed anything for windows mobile OS. Maybe Ballmer was not so crazy when he was running around on stage screaming “Developers, developers, de
44.
by pfisherman 11mo ago
That is because there has been an absolute massacre in biotech in the bay area. Between tariffs (higher COGS), chaos at the FDA, cuts to NIH funding for basic and translational research, and competition from China biotech ventures are gett
45.
by pfisherman 11mo ago
My sense is that AI is the one area where boards cannot justify cutting back on investment. If there were no AI boom the rest of the economy would still be getting hammered. There is still a lot of tech investment, deal making, and hiring
46.
by pfisherman 11mo ago
My pet theory is that we are experiencing stagflation, but only people >70 years old have ever really experienced it before, so most people are just scratching their heads wondering how it’s possible that stocks keep going up (inflation)
47.
by pfisherman 11mo ago
What burden of disease are we talking about here? Ask the question would you be comfortable allowing babies to be maimed or killed in a medical experiment to develop a treatment to some malady? Make no mistake that is what we are talking ab
48.
by pfisherman 11mo ago
This is pretty ridiculous, just stupid enough for a bit of silly Friday watercooler conversation. I have questions. How do facial expression, clothes, and hairstyle impact the model’s predictions? How about Facetune and insta filters? Wou
49.
by pfisherman 1y ago
The word “smart” is doing a lot of work here. And I think both the author and a lot of commenters in this thread are equating it with IQ. What about EQ? I would also consider people with high EQ to be smart. It is a different kind of smar
50.
by pfisherman 1y ago
My main point of skepticism about repurposing is whether this is giving any of new and actionable information. It seems to be reliant on pre existing target annotations, and qualified targets already have molecules designed for them. Is th
51.
by pfisherman 1y ago
This article kind of grinds my gears. I feel like there is an unstated assumption that people in pharma R&D are idiots and haven’t thought of this stuff. Pharma companies care very much about off target effects. Molecules get screened
52.
by pfisherman 1y ago
The list price is mostly a starting point for negotiations with PBMs and payers. Drugs are also often aggregated and bundled. So in a lot of cases is unclear what a drug actually costs.
53.
by pfisherman 1y ago
Ime, there are two causes of heated scientific debates. (1) Conflicting or insufficient data. (2) Communication issues. Cause (1) cannot usually be resolved without some sort of technological innovation. Cause (2) is quite interesting beca
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by pfisherman 1y ago
> One of the realities is more unyielding than the other. Also ten or one hundred (people) is more than one. That math can’t be reasoned out of existence either.
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by pfisherman 1y ago
> They will follow instructions from a workplace superior with zero push-back Zero push-back? Or zero push-back in front of the rest of the group? Humans are pack animals, highly evolved for social connection, and ostracism can be life
56.
by pfisherman 1y ago
Big caveat here is how people are using the LLMs. Here they were using them for things like information recall and ideation. LLMs as producer and human as editor / curator. They did not test another (my preferred) mode of LLM use -
57.
by pfisherman 1y ago
> Personally, I’ve been seeing the number of changes for a PR starting to reach into the mid-hundreds now. And fundamentally the developers who make them don’t understand how they work. Could this be fixed by adjusting how tickets are sc
58.
by pfisherman 1y ago
> But here’s the kicker: we were told AI would free us up for “higher-level work.” What actually happened? We just found more work to fill the space. That two-hour block AI created by automating your morning reports? It’s now packed with
59.
by pfisherman 1y ago
Karpathy’s talk about computing 3.0 was spot on. Look at what is going on with pydantic and langchain. “LLM programming” is about to be a thing.
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by pfisherman 1y ago
Hindsight is 20/20. The company I worked at went under because people questioned whether enough people would ever buy stuff over the internet to make the business viable. It was very much not obvious then. > Gen-AI may be useful t

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