markkat

14 ms·

61.
by markkat 8y ago
This cycle has been repeated and will continue to be repeated until the underlying economic models change.
62.
by markkat 8y ago
Sure. https://www.ncbi.nlm.nih.gov/pubmed/29273086 https://www.ncbi.nlm.nih.gov/pubmed/30149650 It definitely needs more study.
63.
by markkat 8y ago
The trial you linked (as well as the two other registered trials using mesenchymal stem cells for Ankylosing Spondylitis that I found) are using allogeneic (donor) MSCs. I've been in MSC research/development for 17 years and now c
64.
by markkat 8y ago
Ponzi schemes are terrible. Many ICOs aren't much more. However, blockchain enables digital scarcity. That's an interesting piece of technology right there. Using it as a state-machine is a very interesting application of it. IMHO
65.
by markkat 8y ago
TBH part of what makes me so bullish on Ethereum is how much of an emotional reaction it produces, both for and against the technology, all the while it continues to gain mindshare and utility.
66.
by markkat 9y ago
https://hubski.com thoughtful conversations
67.
by markkat 9y ago
Hopefully it’s less than 1 day in length, so those on the far side of earth are shielded.
68.
by markkat 9y ago
It's also not as decentralized as intended in the white paper in regards to transaction. First sentence in the abstract: "A purely peer-to-peer version of electronic cash would allow online payments to be sent directly from one pa
69.
by markkat 9y ago
Perhaps this solves the Fermi Paradox.
70.
by markkat 9y ago
We filed IP on a solution to this in June. :)
71.
by markkat 9y ago
I feel the same. I can't fathom the lack of imagination, and IMHO that's what it is. I've loaded Lemonade Stand on an audio cassette, and with the same fingers, I now type this on a black wafer on a plane.
72.
by markkat 9y ago
Outside of the body in culture? They do seem to age if grown for very long periods of time. This is why we cryopreserve them, it essentially freezes them in time.
73.
by markkat 9y ago
In most cases, you cannot. Cells that are not your own are cleared from the body or rejected in a short time.
74.
by markkat 9y ago
We collect 60mL, less than 10% of what may be drawn in a bone marrow donation by this method, of which there are no known deleterious effects. Our physicians suggest you take it easy for a day or so, but aside from a tender spot, recovery i
75.
by markkat 9y ago
The discomfort is difficult to describe. I best describe it as a cramp. We believe that the negative pressure is in part to blame, and we have filed IP on a possible solution.
76.
by markkat 9y ago
We aren't propagating at intervals currently. However, it's something that could be done; batch samples could be set aside for that purpose alone, also, one control sample could be divided and tested every 5 years. It's an in
77.
by markkat 9y ago
That's an interesting question that is difficult to answer in brief. I believe I covered it a bit in a Google Talk I gave that was posted a couple of days ago: https://www.youtube.com/watch?v=aSRqd1JfoaI In short, I se
78.
by markkat 9y ago
If expanded over many passages in culture, the cells can degrade, much like they do due to age. For this reason, it is advantageous to start with sufficient numbers (thousands), rather than a few cells. However, as mentioned, we have improv
79.
by markkat 9y ago
We've had a few clients ask about this. It's something that were will likely offer in the future. Our biorepository is currently in MA.
80.
by markkat 9y ago
Thanks! We do perform QA on samples post-freeze process. We are working on some uses of these cells for rejuvenation purposes. We will be sharing specifics on that in the coming months. Here are a couple of posts that I made about one exper
81.
by markkat 9y ago
The benefits are not hypothetical, but are in the clinical trial phase. Numerous are phase 3, however. That said, this is not a 'save for next week' service. The idea is that your young biology will likely be advantageous, as the
82.
by markkat 9y ago
In some cases, that may be possible. We have not explored registry/donation at this time.
83.
by markkat 9y ago
Currently, iPS has a high risk of teratoma or malignancy. We haven't yet been able to induce pluripotency in a safe manner. I do believe that it is likely that one day we will overcome this obstacle, however having youthful multipotent
84.
by markkat 9y ago
As mentioned elsewhere here: >>The cell populations are actually quite similar; there are both mesenchymal and hematopoietic stem cells in cord blood and bone marrow. In many ways, our service is 'cord blood banking for adults&#x
85.
by markkat 9y ago
As mentioned above: >The cell populations are actually quite similar; there are both mesenchymal and hematopoietic stem cells in cord blood and bone marrow. In many ways, our service is 'cord blood banking for adults'. However,
86.
by markkat 9y ago
Per our client agreement, they are disposed of unless an arrangement has been made. In some instances, your cells could be useful to someone else (such as an HLA match for bone marrow donation), however for tissue replacement, you are your
87.
by markkat 9y ago
We collect 60mL. There are normally about 10-15M nucleated cells recovered per mL of bone marrow. Stem cell counts are typically 0.01% of this (MSCs are about 1000/mL). We bank the cells in multiple chambers (3 larger ones, 5-6 smaller
88.
by markkat 9y ago
I don't know about smoking, but there have been studies showing the positive impact of exercise on stem cell health.
89.
by markkat 9y ago
A bone marrow biopsy is much more painful than an aspiration, which is what our physicians do. There is variability, but my own experience was a fleeting cramp (3 out of 10), that lasted about 15 seconds. I have been many of our collections
90.
by markkat 9y ago
One possibility is that you will have your young stem cells for the treatment of age-related disease later in life. Stroke: https://clinicaltrials.gov/ct2/show/NCT01716481 Congestive heart failure: https:/&#

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