3 ms·
That's an interesting question that is difficult to answer in brief. I believe I covered it a bit in a Google Talk I gave that was posted a couple of days ago:
by markkat 9y ago
That's an interesting question that is difficult to answer in brief. I believe I covered it a bit in a Google Talk I gave that was posted a couple of days ago:
https://www.youtube.com/watch?v=aSRqd1JfoaI https://www.youtube.com/watch?v=aSRqd1JfoaI
In short, I see storing your youthful multipotent biology giving you an early onramp on pluripotent stem cell induction, however I am not as optimistic as some. Biology is complex and there are blind spots to intervention. We still struggle with male-pattern baldness.
I can say that we are working on what I would like to see come to fruition. That is, take our younger cells, and rejuvenate the bone marrow niche, using our young bone marrow as bone marrow. In addition to that simple 'heterochronic transplantation', I intend to determine how we can improve upon it. Some realistic avenues are 1) removal of resident senescent cells and 2) rejuvenation of the cells ex vivo prior to reintroduction.