3 ms·
The trial you linked (as well as the two other registered trials using mesenchymal stem cells for Ankylosing Spondylitis that I found) are using allogeneic (don
by markkat 8y ago
The trial you linked (as well as the two other registered trials using mesenchymal stem cells for Ankylosing Spondylitis that I found) are using allogeneic (donor) MSCs. I've been in MSC research/development for 17 years and now cryopreserve them as a service (Forever Labs YCS17). From my experience and knowledge of clinical efforts, allogeneic is limited by immuno-rejection of the MSCs after a few days. That's not to say that they can't provide benefit, but just that their window of action is limited as your body recognizes the donor cells as foreign, and weeds them out (perhaps in AS this is enough). The allogeneic issue is actually why I started banking them. I wanted my own young MSCs available to me later in life.
I'd be curious if you can get the clinic in China to expand your own MSCs. I did some MSC research in Beijing long ago. IMO they are ahead of us in many respects, but they also push the envelope more, and you need to be cautious. That goes for everywhere, actually. Just for different reasons.
- rorykoehler 8y agoDo you have any links to studies re immuno-rejection? I've heard it mentioned but I've also heard the opposite from the likes of the stem cell clinic in Panama.
- markkat 8y agoSure. https://www.ncbi.nlm.nih.gov/pubmed/29273086 https://www.ncbi.nlm.nih.gov/pubmed/29273086 https://www.ncbi.nlm.nih.gov/pubmed/30149650 https://www.ncbi.nlm.nih.gov/pubmed/30149650 It definitely needs more study.
- rorykoehler 8y agoThanks. I find it curious as Neil Riordan from the Stem Cell Clinic in Panama says the exact opposite (I think in this video but I haven't had time to find it https://www.youtube.com/watch?v=cLKOddCPs9I https://www.youtube.com/watch?v=cLKOddCPs9I). I can't make up my mind if he's a huckster or not. Based on my investigation through my network (3 degrees of separation) he seems to be legit but of course that is difficult to confirm.