lbeltrame

9 ms·

91.
by lbeltrame 6y ago
There's a major difference. Antigen tests identify a protein of the virus, which can be detected only if you have infectious viruses in your respiratory tract. Less sensitive, but highly useful in absence of symptoms, because you know
92.
by lbeltrame 6y ago
Sputnik is two vectors: Ad26 and Ad5. That looks like the reason why they kept having a high efficacy (today's press release from Gamaleya says 92%). Dosing is done in Phase 1 trials, which also included antibody level testing. This ha
93.
by lbeltrame 6y ago
True asymptomatics are rare in the infected population. Most of people are presymptomatic (=they will develop symptoms), and their peak infectiousness is one or two days before symptom onset, according to published data. > If millions of
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by lbeltrame 6y ago
> Saying that you are not being overconfident with that level of confidence seems like a red flag. Were it just me, I'd agree with you, however it is the data that we must look at: https://science.sciencemag.org/cont
95.
by lbeltrame 6y ago
> I am looking for 14 days quoted in the parent comment and not finding it. 2 to 6 days incubation time is not "long". > I am sympathetic to the idea but being overconfident It's not being overconfident: it's what
96.
by lbeltrame 6y ago
> The long incubation period and asymptomatic carriers makes for easy spread of the virus Long? The median is between 4 and 6 days. The 14 days often quoted is the 99th percentile. Can we stop perpetuating this myth? > asymptomatic ca
97.
by lbeltrame 6y ago
> All the long term studies are being skipped. There are no long term studies. The reason vaccines take so much in "regular" circumstances are: - Actually finding money to run the trials - Run Phase 1, 2, 3 trials one after ano
98.
by lbeltrame 6y ago
What are the long-term effects of vaccines everyone is talking about? This is not a loaded question, I'm asking in good faith. And I ask because even the rarest documented effects occur within 3-4 months of administration, which is har
99.
by lbeltrame 6y ago
Scale-up work and production started at the end of the summer.
100.
by lbeltrame 6y ago
FTR, FDA has approved a product (not a mRNA vaccine) using lipid nanoparticles in 2018. mRNA vaccines had also (limited) human testing before these trials in the past years (mostly Phase 1).
101.
by lbeltrame 6y ago
AFAICR, they're required to put a minimum two week period between the emergency use authorization request and the meeting.
102.
by lbeltrame 6y ago
The FDA released today all the data they're using for the upcoming Dec 10th discussion, and it is quite detailed: https://www.fda.gov/media/144245/download Writing a peer-reviewed paper two weeks after the da
103.
by lbeltrame 6y ago
I call BS on this "error list". First, this doesn't take into account the other tests developed around the world (China, CDC, Institut Pasteur). > The described concentrations lead to increased nonspecific bindings and P
104.
by lbeltrame 6y ago
There's another readout expected in the USA sooner or later, with a far larger cohort (30K people), but for the full/full dose regimen.
105.
by lbeltrame 6y ago
> Not really. mRNA starts to degrade within minutes of injection, and lasts maybe at most a few days in your body. According to the data I've seen on kinetics (these vaccines have been in development since 20 years ago, so there&#x2
106.
by lbeltrame 6y ago
You are correct. The meeting for the "decision" (rather, it is a recommendation on which the European Commission acts upon) is scheduled to be December 28th at the latest.
107.
by lbeltrame 6y ago
Some of the criticisms look... odd. In particular, why just Primer-BLAST of all to check the primer sequences? There are other tools out there for that kind of calculation, and to make sure it weren't an algorithm-specific problem they
108.
by lbeltrame 6y ago
According to the docket[1], materials to be discussed will be posted 2 days before the meeting. The meeting itself will be also streamed. [1] https://www.regulations.gov/docket?D=FDA-2020-N-1898
109.
by lbeltrame 6y ago
Most of this is a summary of the links and the discussions in the r/COVID19 community on reddit (tightly regulated, scientific discussion only). Some: - https://www.reddit.com/r/COVID19/comments/jo2muy&#x
110.
by lbeltrame 6y ago
> 3) at least one of the mink variants of covid-19 is different enough that there is reason to worry the vaccines might not give immunity to it, This is patently false, and the press have kept on saying it wrong to keep the terror givin
111.
by lbeltrame 6y ago
Most adverse events (narcolepsy and GBS included) occur within a few months (1-3) of administration. The fact that some are reported after years doesn't mean they are "long term": it only means it took a while to vaccinate th
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by lbeltrame 6y ago
Up to six months.
113.
by lbeltrame 6y ago
The press release made before the release of the results to the FDA or in a paper is done to be in compliance with insider trading regulations, AFAICS. I'm surprised that the writer at the Financial (emphasis mine) Times did not know
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by lbeltrame 6y ago
Thanks, very informative. I wasn't aware about that one.
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by lbeltrame 6y ago
> How long does the immunity last? If we consider that recovered patients are immune between 6 and 8 months at least, that timeframe seems likely. > What are the long term side effects? I keep on asking myself. What vaccines do truly
116.
by lbeltrame 6y ago
> Pfizer Inc. (New York, NY) in partnership with BioNtech (Germany) has also developed a saRNA prototype vaccine, although the details of this vector/formulation have not been disclosed yet. AFAICS, this is not BNT162b2, which is th
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by lbeltrame 6y ago
Did it? Can you point me to the relevant paper? It's been a while since I read their phase 1 data.
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by lbeltrame 6y ago
The 56-85 age bracket is 45% of the volounteers tested, according to Pfizer.
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by lbeltrame 6y ago
This doesn't replicate, AFAICS. The one in Phase I by Imperial College is instead self-replicating.
120.
by lbeltrame 6y ago
> My DNA will be permanently altered and permanently create fake covid proteins ? No, in fact, mechanisms in cells are in places so that "heteroduplexes" (meaning one filament of RNA and one of DNA paired together) are quickly

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