4 ms·
This doesn't replicate, AFAICS. The one in Phase I by Imperial College is instead self-replicating.
by lbeltrame 6y ago
This doesn't replicate, AFAICS. The one in Phase I by Imperial College is instead self-replicating.
- antgiant 6y agoDid some more searching today and this one does in fact amplify just like the Imperial College one
- lbeltrame 6y agoDid it? Can you point me to the relevant paper? It's been a while since I read their phase 1 data.
- antgiant 6y agohttps://www.sciencedirect.com/science/article/pii/S1879625720300705 https://www.sciencedirect.com/science/article/pii/S187962572... See the section on COVID-19 near the end.
- lbeltrame 6y ago> Pfizer Inc. (New York, NY) in partnership with BioNtech (Germany) has also developed a saRNA prototype vaccine, although the details of this vector/formulation have not been disclosed yet. AFAICS, this is not BNT162b2, which is the one that we are talking about. There are 3 other candidates, one of them is the self-amplifying one.
- antgiant 6y agoLooks like you are right! Thanks for the good news!
- The_rationalist 6y agoSo will this be in significant quantity in my body for years?
- antgiant 6y agoI don’t know. Busy straining my biology knowledge trying to figure that out. The paper seems to imply maybe not? https://www.sciencedirect.com/science/article/pii/S1879625720300705 https://www.sciencedirect.com/science/article/pii/S187962572...