klmr

26 ms·

211.
by klmr 8y ago
The “excessively concerned with sexual propriety” part of the definition applies to what you’ve written. You’ve got some very clear and quite restrictive ideas about how sex is to be enjoyed, and you view other ways as harmful. And, to reit
212.
by klmr 8y ago
If you leave kids alone they also “play doctor”. What’s natural is a poor indicator for what’s a good idea (that said, it’s generally agreed that kids playing doctor is generally a healthy activity — the same is decidedly not true for hit
213.
by klmr 8y ago
Could you give an example? I’m drawing a blank.
214.
by klmr 8y ago
> Not prudish here, just also very conscious [that sex] should be between life-long committed people That is prudish. To be perfectly clear, it’s entirely fine to decide that this is the right thing for yourself. But the way your comme
215.
by klmr 8y ago
> First of all, universities are not per se linked to the scientific method as we understand it nowadays. Yes, that’s kind of my point: The introduction of the scientific method fundamentally changed research, and Universities as insti
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by klmr 8y ago
At least for the English term this is explicitly the reason it was created: to avoid the bad reputation “comic strips” (and the term has been criticised for precisely this, because it’s seen as pretentious).
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by klmr 8y ago
By connection I mean any relevant/enriching piece of communication. Furthermore, apologies for being a bit flippant but if the only things you see on your Facebook friend feed are empty fluff then maybe you need to find more interestin
218.
by klmr 8y ago
Have to ? No. But it’s kind of a sport amongst copy editors. Some of the good reputation of The Economist stems from the fact that they elevated puns (not only in titles) to an art form.
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by klmr 8y ago
I don’t disagree, I just wanted to point out that there’s a close equivalent in the English language that’s a much better fit than the word “comic”.
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by klmr 8y ago
Hmm. I spent my late teens in France, was/am an avid graphic novel reader, and I have never heard the term “roman graphique”. Is it a recent term? It actually sounds like a back-translation of “graphic novel”. The term BD is ubiquitous
221.
by klmr 8y ago
> Universities have […] not fundamentally changed during [the past millennium]. I mean, that’s just completely wrong. The scientific method itself isn’t that old. The institution of Universities has been around for a thousand years, gi
222.
by klmr 8y ago
You forgot the translation: “bande dessinée”, literally, means “drawn strip”, or, equivalently, graphic novel. The latter term exists and matches the French wording pretty closely. “Comic”, by contrasts, really only describes a subset.
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by klmr 8y ago
No, but by that logic such connections existed less before Facebook etc. And this is indeed probably true. And I say that as somebody who doesn’t use Facebook any more, and who lives abroad.
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by klmr 8y ago
> no, i probably couldn't tell it from Grana Padano if i was blindfolded. I can — they are quite different cheeses. Apart from the different taste and texture (Grana Padano has reliably less taste, and is dryer and more crumbly), I
225.
by klmr 8y ago
I do feel that elegant implementations are superior to others (all other things being equal). However, we need to be careful how we define “elegant”. For instance, while I fundamentally understand the drive to eliminate special cases, I don
226.
by klmr 8y ago
Cooking ≠ baking. For baking small changes in relative quantities can actually make a huge difference — maybe not for your simple cake batter but definitely for more elaborate bakes, and even relatively simple standards such as brioche doug
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by klmr 8y ago
> Know what happens to most of the produce that's edible, has enough shape to survive in transit, but looks funny? > IT GOES TO THE GROCERY STORES THAT POOR PEOPLE SHOP AT So I shop a lot at “grocery stores that poor people s
228.
by klmr 8y ago
Hence my correction. Without looking it up now, the actual replication error rate is probably close to the deCODE rate for de novo mutations (modulo gamete selection, so probably higher than that).
229.
by klmr 8y ago
Your comment gives the impression that all DNA sequencing is a multi-million dollar effort. So, just to clarify: a modern, accurate (= 30x coverage) whole-genome DNA sequence costs less than 1000 USD. Adding long range information from si
230.
by klmr 8y ago
Dantelabs does. Note: I am not endorsing their service, I have no experience with them.
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by klmr 8y ago
Maybe so but the kind of genotyping test that we are talking about is vastly more accurate than an over-the-counter pregnancy test, both in the mind of the public and in actual fact.
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by klmr 8y ago
Right, de novo mutation rate is much lower (even lower than what you wrote, just slightly above 1e-8 according to deCODE). The 1/1000 rate is the average difference between two random individuals (not twins), which corresponds to your
233.
by klmr 8y ago
Well 23andme was specifically reprimanded by the FDA for their health related information and blocked from publishing future health advice, until they got limited approval after finally complying with regulation. So it’s inaccurate to say t
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by klmr 8y ago
> Techniques used to read DNA only read short segments, from which larger segments are inferred. I think you’re describing short-read sequencing here but this isn’t what any of these services does. They do microarray genotyping rather
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by klmr 8y ago
No, that’s also incorrect. The real number is way higher. They share 50% of alleles , and hence 50% of variants . But a lot of the DNA within two distinct alleles will be identical, except for (say) a single nucleotide difference.
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by klmr 8y ago
They don’t, this number is extremely misleading. Roughly 97% (I think is the current estimate) of their protein-coding DNA is equivalent , but not 1:1 identical.
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by klmr 8y ago
Current estimates are that there’s a roughly 1 in 1000 difference between two individuals purely due to random mutations in the germline (or, put differently, the DNA replication error rate in human cells is about 1 in 1000). This would imp
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by klmr 8y ago
It’s not export control, it’s a US trade embargo: https://en.wikipedia.org/wiki/Sanctions_against_Iran
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by klmr 8y ago
Just a small note: lateral gene transfer (= horizontal gene transfer) also exists in eukaryotes, although it’s much rarer than in bacteria. Nevertheless, the human genome is actually full of genetic elements that were originally transferr
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by klmr 8y ago
Marshall Cline’s FAQ been absorbed by the “official” C++ FAQ: https://isocpp.org/faq

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