3 ms·
Right, de novo mutation rate is much lower (even lower than what you wrote, just slightly above 1e-8 according to deCODE). The 1/1000 rate is the average differ
by klmr 8y ago
Right, de novo mutation rate is much lower (even lower than what you wrote, just slightly above 1e-8 according to deCODE). The 1/1000 rate is the average difference between two random individuals (not twins), which corresponds to your 3M SNPs per 3B bases.
- adenadel 8y agoYes, but you referred to them as random mutations, which is not the case. They are inherited variants. The DNA replication error rate is nowhere near 1 in 1000.
- klmr 8y agoHence my correction. Without looking it up now, the actual replication error rate is probably close to the deCODE rate for de novo mutations (modulo gamete selection, so probably higher than that).