klmr

30 ms·

241.
by klmr 8y ago
It’s a fairly direct path, since computational drug discovery relies heavily on protein folding predictions.
242.
by klmr 8y ago
You might be interested in computer-aided drug design [1], in particular computational target prediction. It’s a fairly big field (both in academic research and in commercial application), and not exactly new. This is technically a subfie
243.
by klmr 8y ago
No. The 800 kcal/day liquid diet is kept up for three months. However, the resulting weight loss is sustained long term.
244.
by klmr 8y ago
This new diet is specifically tailored to avoid this yoyo effect. It’s currently not yet clear whether this is indeed the case (hence this expanded epidemiological study) but preliminary results indicate that this is indeed the case. In o
245.
by klmr 8y ago
They sequence at 30x using BGI technology. Meaning: They provide the current offer at a loss.
246.
by klmr 8y ago
Identifying and removing contaminants is a routine step in DNA-seq analysis. They might still flag and discard the sample internally but treating it would be trivial.
247.
by klmr 8y ago
VCF only contains variant information; FASTQ and BAM contain the “raw” sequencing information (in reality that data is already heavily processed but it’s the starting point for all usual analysis). Depending on how you do the analysis, the
248.
by klmr 8y ago
> I know [privacy is] an issue around 23&me In what regard? I’ve not heard of any privacy related issue with 23andme, and I follow the field quite closely (professional interest). On the contrary, 23andme has been known to uphold cus
249.
by klmr 8y ago
They’re not. They are using BGI’s MGISEQ2000 machines. They simply sell the sequencing at a price that doesn’t cover its cost. Both because this is a promotion and because they retain the rights to using your genomic data in research: it’s
250.
by klmr 8y ago
Real numbers for Illumina sequencing currently hover at around 600 USD per 30x coverage human WGS (and this is pure sequencing cost, excluding data storage and analysis). Prices are not dropping since Illumina has no real incentive at the
251.
by klmr 8y ago
I was talking specifically in the context of OP’s comment. I otherwise agree with you. But the wording that OP seems to complain about simply means that, in order to perform the requested analysis, the company needs to temporarily store you
252.
by klmr 8y ago
Not sure I understand your concern: It’s standard boilerplate for the case where private data is required to run an analysis, but is not otherwise used. Not saying that it should necessarily be trusted but the wording isn’t problematic. Wha
253.
by klmr 8y ago
Previous discussion on HN: https://news.ycombinator.com/item?id=18084054
254.
by klmr 8y ago
The oocyte doesn’t have a direct way of recognising that sperm is stressed. However, stress does weird things to cells (the sperm, in this case), and the consequences of that are often severe. This definitely has an effect on the fitness of
255.
by klmr 8y ago
> These sorts of discoveries really push towards a re-evaluation of Lamarck's thought, frankly. They fundamentally don’t. Lamarckism was an explanatory model for evolution, and even if these results turn out to be true, they are n
256.
by klmr 8y ago
Your instinct is spot on. These stress inheritance studies were widely panned by experts (see e.g. https://www.theguardian.com/science/blog/2015/sep/11/why-im-... ).
257.
by klmr 8y ago
> this or epigenetic inheritance This is an instance of epigenetic inheritance. As for your question, we don’t know yet (also because these results are still terribly preliminary). It’s conceivable that stress permanently modifies some
258.
by klmr 8y ago
> and when spoken it's not very distinguishable from "smelled" In fact “smelt” is a completely valid alternative spelling of “smelled” (see https://en.wiktionary.org/wiki/smell#Verb ).
259.
by klmr 8y ago
Conversely, I got a point deduction on my master thesis for including too many (almost exclusively academic) references. Mental. (They were all relevant.)
260.
by klmr 8y ago
No town as far as I could find but several rivers called Fish. So yes, you can fish Fish fish.
261.
by klmr 8y ago
Unfortunately I don’t think the German variant works due to the verb “büffeln” being intransitive. Apart from that, the presence of inflection in German renders the sentence less aesthetically pleasing but alleviates the exact ambiguity tha
262.
by klmr 8y ago
Yeah, the way they talk about this is admittedly confusing. The best way for me to think about it (from [1]) is to mentally add quotation marks around the word “image” whenever the methods mention it. Mathematically the data is stored in hi
263.
by klmr 8y ago
DeepVariant didn’t actually explicitly encode the variants (nor the raw data) as images. Press reports —including from Google Research itself) suggested that this was the case but nothing in the original publication said so, and the researc
264.
by klmr 8y ago
True but that’s purely for legal/ethical reasons, not (directly) scientific ones. Most scientific uses of CRISPR (and other gene editing techniques) by far happen in the germ line. Germ line research (and, thus, applications) are lac
265.
by klmr 8y ago
Yep, the RStudio integration is very nice. However, there are other ways of authoring R Notebooks that also allow interactivity, and the only thing that’s missing then is having output inline inside the editable document. Apart from tha
266.
by klmr 8y ago
It was obviously inspired by many different things but the most direct genealogy is WEB [1] → noweb → Sweave → Knitr → R Markdown → R Notebooks. Mathematica’s notebook interface in turn was almost certainly also inspired (directly or indire
267.
by klmr 8y ago
The article claims that > R Notebooks can only be created and edited in RStudio Luckily, this is wrong . Since R Notebooks are simply R Markdown, they can be edited with any editor (although the integration is obviously lost). This
268.
by klmr 8y ago
That’s in fact what is being done.
269.
by klmr 8y ago
The difference between CRISPR and many other overhyped technologies is that CRISPR has already proven its mettle. It’s being used productively daily in labs across the world and has lowered the cost of performing many experiments, or even m
270.
by klmr 8y ago
This is true for most genetic engineering applications but not all. Somatic gene therapy has been successfully performed in a few cases. There will almost certainly be more applications in the future, and it’s reasonable to expect that they

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