klmr

52 ms·

451.
by klmr 9y ago
It hasn’t been published yet.
452.
by klmr 9y ago
It’s not mentioned because it hasn’t been studied yet. That said, side-effects from IVF can be explained much easier, no need to invoke degrading sperm RNA (which is almost certainly not required for healthy fertilisation, and rather a s
453.
by klmr 9y ago
> I am very sceptical of statistical findings like this with a poorly/not understood mechanism. And you’re right to be (in fact, this is exactly the same instinct researchers get). We’ll have to wait until the actual research articl
454.
by klmr 9y ago
As somebody who’s working on a highly related topic, I’m thrilled to see the research explained so well here. But unfortunately I am unable to assess the quality of the findings because the researchers have decided to buck convention and
455.
by klmr 9y ago
Yes — but only if, as in Haskell, that syntactic sugar was generalisable. The whole point of monads is that they are a powerful generalisation that can be used to solve many apparently very different problems. Compared with the syntactic su
456.
by klmr 9y ago
The difference is given by the code context (which is unfortunately entirely missing from the article). What’s shown here are the things all these patterns have in common . The whole point of abstraction is to have different, but related,
457.
by klmr 9y ago
Both arguments exist, although I don’t think the “ageing was actively evolved” argument has ever gained a lot of mainstream traction: it’s not very parsimonious (all the available evidence can also be explained by the simpler model).
458.
by klmr 9y ago
> Molecules don't age But they do. The article argues that molecule ensembles are damaged by thermal motion but there are other ways in which molecules are damaged over time due to chemical and physical stress. Large molecules in th
459.
by klmr 9y ago
> The headline's premise The author mentions in a comment that he didn’t write the headline (as is so often the case). His original headline (“Aging: where physics meets biology”) is much less controversial.
460.
by klmr 9y ago
I’m not arguing that. I’m arguing that a nociceptor is necessary but not sufficient to argue for pain experience. And plants don’t even fulfil this basic, necessary criterion. So the “type of work” shown in the article isn’t the same ki
461.
by klmr 9y ago
> In lots of areas, "good code" doesn't matter much, if at all. This is the received wisdom in biological science but I’m convinced that it’s trivially wrong. I’ve seen a lot of research code, most of it bad. I have no i
462.
by klmr 9y ago
> Yet this is the same type of work people are using to argue that that crabs/fish can feel/experience pain. Not really: a fundamental requirement in the assessment of pain reception in animals is the presence and stimulation o
463.
by klmr 9y ago
> We have an unfortunate obsession with form over content I partially agree with this observation but I also think that it’s a bit misleading: especially if used, as here, to refer to the distinction between programming languages (and
464.
by klmr 9y ago
> but when a study size is small and you still find a difference, then it implies the effect size is large That’s only true if it holds across multiple studies. Otherwise it might simply be random variability. By your argument, a study
465.
by klmr 9y ago
Not only. Life expectancy has increased in every age group percentile. But the effect is obviously not due to tea, coffee and turmeric. Rather, it’s due, mainly, to (a) better general nutrition, (b) better hygiene, and (c) modern medicine,
466.
by klmr 9y ago
> In this case, for instance, turmeric has been used for medicinal properties in Asian cultures for centuries. Theories of evolution suggest that this wouldn't be the case (and it would've died a natural death), if there wasn&#
467.
by klmr 9y ago
> very few people would place Scandinavia in north-western Europe Not really. I don’t presume to claim to know what “most” people think, but placing Scandinavia in north-western Europe is hardly eccentric [1, 2]. Furthermore, its history
468.
by klmr 9y ago
Please note that the UCL page specifically distinguishes DNA ancestry testing from genetic astrology: DNA ancestry testing is in principle scientifically valid, albeit still fairly imprecise due to sparse data.
469.
by klmr 9y ago
You’re right. I also find it telling that John Sotos doesn’t give a single argument for his recommendation. He simply “proclaims” that you shall not share your genome “without good reason”. He says that everything in life is a cost–benefit
470.
by klmr 9y ago
I’m still not happy with this characterisation. By “genome testing” I suspect you mean whole-genome sequencing (WGS) [1]. First off, this is also a form of genotyping. And, depending on which definition of accuracy you’re using, it’s no m
471.
by klmr 9y ago
I don’t know where you get this idea because genotyping is (a form of) genetic testing. And as for accuracy, human reference genome databases are highly accurate. Sure, they’re not error-free — but then nothing is. Ancestry in particular
472.
by klmr 9y ago
> The gains are like 1% too If that. I’m sceptical (and so are others). Given that all methods are imprecise, it’s not terribly hard to find a special case on which method X outperforms all the others. But on average?
473.
by klmr 9y ago
The “DeepVariant” example exemplifies the problem with deep learning in biology: some exceptions (when actual imaging is involved) notwithstanding, we still haven’t found a good use for it. Most problems that we can formulate in biology are
474.
by klmr 9y ago
You can split hunks manually by editing (hit “e” instead of “s” during staging). I end up doing this fairly regularly.
475.
by klmr 9y ago
Good point: unless it’s completely random it’s never entirely avoidable — there’s an element of skill. And I still think that Dominion can be very fun with beginners (that’s my experience at least). That said, there are games that level the
476.
by klmr 9y ago
Dominion’s problem as a beginners’ game is that an even somewhat experienced player has a huge edge over a complete novice: even a passing familiarity with the cards will open up strategic combinations. In addition, they’ll have a hunch for
477.
by klmr 9y ago
> What you are describing is not possible. Local law cannot be broken with location and workforce from an international organisation operating within that country You are quite mistaken. Though “broken” is the wrong word: it’s simply not
478.
by klmr 9y ago
Since it’s an intergovernmental organisation, the country of residence isn’t relevant: it’s not bound by local law. In fact, the company I’ve been working with has outstations in five different European countries, and all outstations have t
479.
by klmr 9y ago
I can’t speak for individual countries (though you seem to be right about the legality in Germany) but in general this is incorrect: My previous employer (a European intergovernmental organisation) had explicit, written rules against superi
480.
by klmr 9y ago
> not improving macOS won’t make anyone upset enough to switch back I’m not so sure about this — although it may be due more to the hardware side of their business: after the recent, disappointing iteration of their MacBook Pros I’ve hea

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