klmr

60 ms·

481.
by klmr 9y ago
> Wait, is the definition of "pun" just that you're using words with a double meaning? Yes, that’s pretty much by definition a pun (though it’s usually required to be topical). For instance, Google gives us: “a joke exploi
482.
by klmr 9y ago
> NGS on the other side is more or less a gradual development. While true that’s not really relevant. What’s relevant is that it has completely revolutionised biomedical research. And although CRISPR has the potential of doing the same,
483.
by klmr 9y ago
Aw you really missed a chance there: you could have deplored their fishing for puns.
484.
by klmr 9y ago
Yes, there’s a German platform that did this fairly successfully: Krautreporter [1] (the article mentions that they were in turn inspired by a Dutch magazine). I know nothing about their finances but they seem to be doing well, and have est
485.
by klmr 9y ago
> Medical research has advanced a lot with the invention of CRISPR. You are overestimating the importance of CRISPR. Don’t get me wrong — it is hugely important and innovative. But it’s not even the most important biomedical research i
486.
by klmr 9y ago
> Does this really bring a lot of value? In this particular case, none whatsoever. It’s egregious abuse of macros.
487.
by klmr 9y ago
The function can be trivially implemented in C, since you don’t need a generic input argument type. No idea why OP chose macros in the first place.
488.
by klmr 9y ago
The first LISP implementation was famously done in machine code, not assembly.
489.
by klmr 9y ago
As alluded to above, “Strong CT” confusingly refers to several very similar, yet different, concepts. I think this is throwing people off. Quantum computers will almost certainly not disprove the CTD principle [1], which is also known a
490.
by klmr 9y ago
> These are the physical limitations of classical computation Classical computation (i.e. the Turing machine) is a mathematical model, and isn’t bound by the physical limitations you imagine. In particular, a Turing machine (which, aft
491.
by klmr 9y ago
Non-recursive in this context means functions that aren’t computationally equivalent to those computable by recursive functions only [1]. This is equivalent to Turing completeness. It’s the second & third meaning in your link. A “non-re
492.
by klmr 9y ago
You’re exactly right. What I don’t see is how Roberts’ experiments help advancing that engineering challenge; the article gave no details about the injection, such as the vector being used to get the genetic material into cells, or the carr
493.
by klmr 9y ago
Note that cause and effect have not been established here. This guy has been going without HAART two years, rashes and nausea are probably not terribly uncommon. The fact that the white blood cell count went up is likewise unsurprising: it’
494.
by klmr 9y ago
Saying — based on evidence — that somebody is stupid isn’t an ad hominem . At worst it’s shorthand for “ his actions are stupid”. Which, given the evidence, they unarguably are: Virtually every expert in the field, as well as other biohac
495.
by klmr 9y ago
The problem is that the researcher is set up as a terrible straw man, and that in turn makes Adam look a bit like an asshole here, even before getting to animal testing: To start off, she claims that “you can’t [prove things wrong in] sci
496.
Why I injected myself with an untested gene therapy(bbc.co.uk)
27 points by klmr 9y ago|65 comments
497.
by klmr 9y ago
I had a hard time believing that quote at the time. John ended up answering the question I asked about it on SuperUser [1] with details about his setup. His writeup is impressive: he actually set up a high-speed camera to record the actual
498.
by klmr 9y ago
In theory it should, and substantially, since DNA replication is a highly energy dependent process. In practice we can’t just nilly-willy remove genetic material from our chromosomes, even if it ostensibly has no useful function. That said,
499.
by klmr 9y ago
Bacteria copy DNA efficiently, but not very faithfully. As it’s not affected by selective pressure, the data would thus degrade extremely quickly. Rather than freezing bacteria, dry and freeze the DNA directly. Much better for preservation,
500.
by klmr 9y ago
For stop codons to be relevant the first step would have to be to transcribe the synthetic DNA into RNA, which would require the presence of adequate promoter sequences. Given their complexity and spacing, this would already be quite unlike
501.
by klmr 9y ago
The title suggests that this is an entirely new achievement. But (as also mentioned in the article), this has been possible for several years, since 2012 [1]. Steady progress is being made at decreasing the cost. But the procedure itself is
502.
by klmr 9y ago
You hang out with the wrong geneticists. Most do not consider most traits to be monogenetic. It’s just vastly easier to focus on them when doing research. But the field as a whole has long since accepted that most interesting traits aren’
503.
by klmr 9y ago
Right, this seems obvious. Any idea why they opted not to go that way? I guess the reason is that the original use-case was VS Code & TypeScript (?) and developing a lowest common denominator API for all clients would mean C, so they wo
504.
by klmr 9y ago
Unlikely. As a selective mechanism its effect would be very subtle, and there are other, well-known, much stronger mechanisms that prevent conception. Age of the mother was mentioned. More generally, it’s defects in the oocyte’s ability to
505.
by klmr 9y ago
> Free speech is only an unalienable right, in the US, from the government. You’re confusing the concept of Free Speech and the law codified in the First Amendment rights. Free Speech as a concept is (by necessity) much broader (both as
506.
by klmr 9y ago
> C++ doesn't completely free you from considering whether a type allocates memory on the stack or on the heap You’re completely right but the way this is phrased shows a common misconception about C++/RAII: it was never about
507.
by klmr 9y ago
> I believe rust would be a better example here From what I’ve heard you’re almost certainly right. I just don’t know enough about Rust to comment on it (unlike C++).
508.
by klmr 9y ago
> C++ abstractions get you in a mindset that might be detrimental to performance. That certainly depends on the application but having been involved with several high-performance libraries written in C++, I can say confidently that C++ a
509.
by klmr 9y ago
> When they are as fast as C, they also look like C regardless what it was to begin with. … Unless your language offers appropriate zero-overhead abstractions. C++, for all its flaws, does this extremely well. Then again, C++ is of cours
510.
by klmr 9y ago
I think the reason this wasn’t enabled until now is that the JIT didn’t universally make code faster. There were some specific cases where it in fact made code slower . I’d love to know whether/how this was solved.

More ›