3 ms·
I’m still not happy with this characterisation. By “genome testing” I suspect you mean whole-genome sequencing (WGS) [1]. First off, this is also a form of geno
by klmr 9y ago
I’m still not happy with this characterisation. By “genome testing” I suspect you mean whole-genome sequencing (WGS) [1]. First off, this is also a form of genotyping. And, depending on which definition of accuracy you’re using, it’s no more accurate. It just provides more signal (because it looks at much larger parts of the genome than microarray genotyping [2] does). The technology used by 23andme and DNA ancestry services (microarrays) will miss some information, compared to WGS (= lower recall [3]). But importantly its precision is no lower than WGS (in fact, until very recently it was higher).
The fact that DNA ancestry estimates are inaccurate for some people is largely unrelated to the technology (microarray vs sequencing), and rather to the fact that our reference set for ancestry is too sparse (especially outside of Europe).
[1] https://en.wikipedia.org/wiki/Whole_genome_sequencing https://en.wikipedia.org/wiki/Whole_genome_sequencing
[2] https://en.wikipedia.org/wiki/DNA_microarray https://en.wikipedia.org/wiki/DNA_microarray
[3] https://en.wikipedia.org/wiki/Precision_and_recall https://en.wikipedia.org/wiki/Precision_and_recall